Hypothalamic FTO promotes high-fat diet-induced leptin resistance in mice through increasing CX3CL1 expression

FTO knockout in adipose tissue effectively alleviates hepatic steatosis partially via increasing the secretion of adipocyte-derived IL-6

(2022) Botao Zeng et al.   GENE

The central nervous system control of energy homeostasis: High fat diet induced hypothalamic microinflammation and obesity

(2022) Lihong Yan et al.   BRAIN RESEARCH BULLETIN

Deficiency of Irx5 protects mice from obesity and associated metabolic abnormalities

(2022) Joe Eun Son et al.   INTERNATIONAL JOURNAL OF OBESITY

Inhibition of hypothalamic FTO activates STAT3 signal through ERK1/2 associated with reductions in food intake and body weight

(2022) Fei Hu et al.   NEUROENDOCRINOLOGY

CX3CL1–CX3CR1 signalling deficiency exacerbates obesity-induced inflammation and insulin resistance in male mice

(2021) Mayumi Nagashimada et al.   ENDOCRINOLOGY

Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes

(2021) Paul S. Baxter et al.   Cell Reports

Leptin receptor-expressing pericytes mediate access of hypothalamic feeding centers to circulating leptin

(2021) Liliia I. Butiaeva et al.   Cell Metabolism

Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5

(2021) Débora R. Sobreira et al.   SCIENCE

Irx3 and Irx5 - Novel Regulatory Factors of Postnatal Hypothalamic Neurogenesis

(2021) Zhengchao Dou et al.   Frontiers in Neuroscience

N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1α signalling axis

(2019) Changshui Zhuang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

N 6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential

(2018) Dandan Yang et al.   NUCLEIC ACIDS RESEARCH

Leptin Receptor Expression in Mouse Intracranial Perivascular Cells

(2018) Xuefeng Yuan et al.   Frontiers in Neuroanatomy

High-fat diet consumption alters energy metabolism in the mouse hypothalamus

(2018) Blanca Lizarbe et al.   INTERNATIONAL JOURNAL OF OBESITY

Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis

(2017) Liping Li et al.   HUMAN MOLECULAR GENETICS

Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice

(2017) Mauricio D. Dorfman et al.   Nature Communications

m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

(2017) Qi Cui et al.   Cell Reports

Saponins and Flavonoids from Adzuki Bean (Vigna angularis L.) Ameliorate High-Fat Diet-Induced Obesity in ICR Mice

(2017) Rui Liu et al.   Frontiers in Pharmacology

Baicalin exerts protective effects against lipopolysaccharide-induced acute lung injury by regulating the crosstalk between the CX3CL1-CX3CR1 axis and NF-κB pathway in CX3CL1-knockout mice

(2016) XIN-MIN DING et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Hypomorphism of Fto and Rpgrip1l causes obesity in mice

(2016) George Stratigopoulos et al.   JOURNAL OF CLINICAL INVESTIGATION

Mangosteen Extract Attenuates the Metabolic Disorders of High-Fat-Fed Mice by Activating AMPK

(2016) Hee-Sung Chae et al.   JOURNAL OF MEDICINAL FOOD

FTO is necessary for the induction of leptin resistance by high-fat feeding

(2015) Y.C. Loraine Tung et al.   Molecular Metabolism

The fractalkine/Cx3CR1 system is implicated in the development of metabolic visceral adipose tissue inflammation in obesity

(2014) Ágnes Polyák et al.   BRAIN BEHAVIOR AND IMMUNITY

FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver

(2014) Amélie Bravard et al.   Cell Communication and Signaling

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

Fractalkine (CX3CL1) Is Involved in the Early Activation of Hypothalamic Inflammation in Experimental Obesity

(2014) Joseane Morari et al.   DIABETES

Leptin Resistance Is Not the Primary Cause of Weight Gain Associated With Reduced Sex Hormone Levels in Female Mice

(2014) Regina P. da Silva et al.   ENDOCRINOLOGY

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function

(2014) Martin Valdearcos et al.   Cell Reports

Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity

(2014) João A.B. Pedroso et al.   Molecular Metabolism

FTO Deficiency Induces UCP-1 Expression and Mitochondrial Uncoupling in Adipocytes

(2013) D. Tews et al.   ENDOCRINOLOGY

The cardiovascular actions of fractalkine/CX3CL1 in the hypothalamic paraventricular nucleus are attenuated in rats with heart failure

(2013) P. J. Ruchaya et al.   EXPERIMENTAL PHYSIOLOGY

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

Transcriptome-wide mapping of N6-methyladenosine by m6A-seq based on immunocapturing and massively parallel sequencing

(2013) Dan Dominissini et al.   Nature Protocols

Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse

(2013) Fiona McMurray et al.   PLoS Genetics

FTO, RNA epigenetics and epilepsy

(2012) Joie Rowles et al.   Epigenetics

FTO levels affect RNA modification and the transcriptome

(2012) Tea Berulava et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

FTO genotype is associated with phenotypic variability of body mass index

(2012) Jian Yang et al.   NATURE

Knockdown of the Fat Mass and Obesity Gene Disrupts Cellular Energy Balance in a Cell-Type Specific Manner

(2012) Ryan T. Pitman et al.   PLoS One

Reversible RNA adenosine methylation in biological regulation

(2012) Guifang Jia et al.   TRENDS IN GENETICS

N6-methyl-adenosine (m6A) in RNA: An Old Modification with A Novel Epigenetic Function

(2012) Yamei Niu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Functions of Noncoding RNAs in Neural Development and Neurological Diseases

(2011) Shan Bian et al.   MOLECULAR NEUROBIOLOGY

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

CNS leptin and insulin action in the control of energy homeostasis

(2010) Bengt F. Belgardt et al.   Annals of the New York Academy of Sciences

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

(2010) A. S. Reed et al.   DIABETES

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS

Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats

(2010) Yi-Chun Loraine Tung et al.   PLoS One

The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice

(2010) Xue Gao et al.   PLoS One

Hypothalamic FTO is associated with the regulation of energy intake not feeding reward

(2009) Pawel K Olszewski et al.   BMC NEUROSCIENCE

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

(2009) Shingo Kajimura et al.   NATURE

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Molecular and neural mediators of leptin action

(2008) Scott A. Robertson et al.   PHYSIOLOGY & BEHAVIOR

Mechanisms of Leptin Action and Leptin Resistance

(2007) Martin G. Myers et al.   Annual Review of Physiology