Lycopene and Apo-10′-lycopenoic Acid Have Differential Mechanisms of Protection against Hepatic Steatosis in β-Carotene-9′,10′-oxygenase Knockout Male Mice

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

(2014) Lee D. Roberts et al.   Cell Metabolism

High-Refined–Carbohydrate and High-Fat Diets Induce Comparable Hepatic Tumorigenesis in Male Mice

(2014) Blanche C. Ip et al.   JOURNAL OF NUTRITION

β-Carotene-9′,10′-Oxygenase Status Modulates the Impact of Dietary Tomato and Lycopene on Hepatic Nuclear Receptor–, Stress-, and Metabolism-Related Gene Expression in Mice

(2014) Hsueh-Li Tan et al.   JOURNAL OF NUTRITION

Nonalcoholic fatty liver disease and serum lipoproteins: The Multi-Ethnic Study of Atherosclerosis

(2013) Andrew Paul DeFilippis et al.   ATHEROSCLEROSIS

Lycopene Metabolite, Apo-10'-Lycopenoic Acid, Inhibits Diethylnitrosamine-Initiated, High Fat Diet-Promoted Hepatic Inflammation and Tumorigenesis in Mice

(2013) B. C. Ip et al.   Cancer Prevention Research

Substrate Specificity of Purified Recombinant Human β-Carotene 15,15′-Oxygenase (BCO1)

(2013) Carlo dela Seña et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Genetic ablation of carotene oxygenases and consumption of lycopene or tomato powder diets modulate carotenoid and lipid metabolism in mice

(2013) Nikki A. Ford et al.   NUTRITION RESEARCH

Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma: Implications for Lycopene Intervention

(2013) Blanche Ip et al.   Nutrients

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

(2013) Melania Gaggini et al.   Nutrients

Lycopene metabolism and its biological significance

(2012) Xiang-Dong Wang   AMERICAN JOURNAL OF CLINICAL NUTRITION

Apolipoprotein B Synthesis Inhibition With Mipomersen in Heterozygous Familial Hypercholesterolemia

(2012) Evan A. Stein et al.   CIRCULATION

Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance

(2012) L. Zhu et al.   DIABETES

Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace

(2012) György Baffy et al.   JOURNAL OF HEPATOLOGY

Apo-10'-Lycopenoic Acid, a Lycopene Metabolite, Increases Sirtuin 1 mRNA and Protein Levels and Decreases Hepatic Fat Accumulation in ob/ob Mice

(2012) Jayong Chung et al.   JOURNAL OF NUTRITION

Sex differences during the course of diet-induced obesity in mice: adipose tissue expandability and glycemic control

(2011) D Medrikova et al.   INTERNATIONAL JOURNAL OF OBESITY

Importance of β,β-carotene 15,15′-monooxygenase 1 (BCMO1) and β,β-carotene 9′,10′-dioxygenase 2 (BCDO2) in nutrition and health

(2011) Georg Lietz et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

The Portal Theory Supported by Venous Drainage-Selective Fat Transplantation

(2010) J. M. Rytka et al.   DIABETES

A mitochondrial enzyme degrades carotenoids and protects against oxidative stress

(2010) Jaume Amengual et al.   FASEB JOURNAL

Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study

(2010) Christopher D. Williams et al.   GASTROENTEROLOGY

Identification and Quantification of Apo-lycopenals in Fruits, Vegetables, and Human Plasma

(2010) Rachel E. Kopec et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism

(2010) Bhaskar Ponugoti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Carotene-9′,10'-Monooxygenase Expression Increases Serum and Tissue Lycopene Concentrations in Lycopene-Fed Mice

(2010) Nikki A. Ford et al.   JOURNAL OF NUTRITION

Lycopene inhibits proinflammatory cytokine and chemokine expression in adipose tissue

(2010) E. Gouranton et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease

(2010) Giovanni Targher et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparison of the Relative Contributions of Intra-Abdominal and Liver Fat to Components of the Metabolic Syndrome

(2010) Anna Kotronen et al.   Obesity

To scale or not to scale: the principles of dose extrapolation

(2009) Vijay Sharma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

Sex difference in the liver of hepatocyte-specific Pten-deficient mice: A model of nonalcoholic steatohepatitis

(2009) Yumiko Anezaki et al.   HEPATOLOGY RESEARCH

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice

(2008) Galyna Bryzgalova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Dietary Palmitoleic Acid on Plasma Lipoprotein Profile and Aortic Cholesterol Accumulation Are Similar to Those of Other Unsaturated Fatty Acids in the F1B Golden Syrian Hamster

(2008) Nirupa R. Matthan et al.   JOURNAL OF NUTRITION

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL