Apo-10'-Lycopenoic Acid, a Lycopene Metabolite, Increases Sirtuin 1 mRNA and Protein Levels and Decreases Hepatic Fat Accumulation in ob/ob Mice

Increased Apoptosis in High-Fat Diet–Induced Nonalcoholic Steatohepatitis in Rats Is Associated with c-Jun NH2-Terminal Kinase Activation and Elevated Proapoptotic Bax

(2018) Yan Wang et al.   JOURNAL OF NUTRITION

Prevention and Reversion of Nonalcoholic Steatohepatitis in OB/OB Mice by S-Nitroso-N-Acetylcysteine Treatment

(2013) Claudia P. M. S. de Oliveira et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Changes in the Prevalence of the Most Common Causes of Chronic Liver Diseases in the United States From 1988 to 2008

(2011) Zobair M. Younossi et al.   Clinical Gastroenterology and Hepatology

Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

(2011) Yu Li et al.   FASEB JOURNAL

Organic Synthesis of New Putative Lycopene Metabolites and Preliminary Investigation of Their Cell-Signaling Effects

(2011) Eric Reynaud et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Enzymatic formation of apo-carotenoids from the xanthophyll carotenoids lutein, zeaxanthin and β-cryptoxanthin by ferret carotene-9′,10′-monooxygenase

(2010) Jonathan R. Mein et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A polyphenol extract modifies quantity but not quality of liver fatty acid content in high-fat–high-sucrose diet-fed rats: possible implication of the sirtuin pathway

(2010) Manar Aoun et al.   BRITISH JOURNAL OF NUTRITION

A mitochondrial enzyme degrades carotenoids and protects against oxidative stress

(2010) Jaume Amengual et al.   FASEB JOURNAL

FoxO1 represses LXRα-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells

(2010) Xiaojun Liu et al.   FEBS LETTERS

Identification and Quantification of Apo-lycopenals in Fruits, Vegetables, and Human Plasma

(2010) Rachel E. Kopec et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effect of Lycopene on Caspase-3 Enzyme Activation in Liver of Methanol-Intoxicated Rats: Comparison with Fomepizole

(2010) Mehmet Ali Kurcer et al.   JOURNAL OF MEDICINAL FOOD

Moderate Alcohol Consumption Aggravates High-Fat Diet Induced Steatohepatitis in Rats

(2009) Yan Wang et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice

(2009) Yu Yamazaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice

(2009) Zheng Shen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Sirtuins regulate key aspects of lipid metabolism

(2009) David J. Lomb et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

To scale or not to scale: the principles of dose extrapolation

(2009) Vijay Sharma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

Structure activity relationship of carotenoid derivatives in activation of the electrophile/antioxidant response element transcription system

(2009) Karin Linnewiel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin E supplementation does not prevent ethanol-reduced hepatic retinoic acid levels in rats

(2009) Jayong Chung et al.   NUTRITION RESEARCH

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

Regulation of SREBP1c Gene Expression in Skeletal Muscle: Role of Retinoid X Receptor/Liver X Receptor and Forkhead-O1 Transcription Factor

(2008) Yasutomi Kamei et al.   ENDOCRINOLOGY

Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases

(2008) Sudheer K. Mantena et al.   FREE RADICAL BIOLOGY AND MEDICINE

Enzymatic metabolites of lycopene induce Nrf2‐mediated expression of phase II detoxifying/antioxidant enzymes in human bronchial epithelial cells

(2008) Fuzhi Lian et al.   INTERNATIONAL JOURNAL OF CANCER

Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats

(2008) Yan Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Biological activity of lycopene metabolites: implications for cancer prevention

(2008) Jonathan R Mein et al.   NUTRITION REVIEWS

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA