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Change Is in the Air: The Hypoxic Induction of Phenotype Switching in Melanoma

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)

Journal

JOURNAL OF INVESTIGATIVE DERMATOLOGY

Volume 133, Issue 10, Pages 2316-2317

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NATURE PUBLISHING GROUP

DOI: 10.1038/jid.2013.208

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Dermatology

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Abstract

Melanoma cells can switch from a highly proliferative, less invasive state to a highly invasive, less proliferative state, a phenomenon termed phenotype switching. This results in a highly heterogenous tumor, where a slow-growing, aggressive population of cells may resist tumor therapy, and it predicts tumor recurrence. Here we discuss the observation made by Widmer et al. that hypoxia may drive phenotype switching.

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