Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 931, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2022.175229
Keywords
M1 macrophage; M2 macrophage; Cancer; Tumour-associated macrophages (TAMs)
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Funding
- Bringing in talent scientific starting project grant of Tongji University Affiliated Yangpu Hospital
- project of Shanghai Municipal Health Commission [202140232]
- Climb Plan of Tongji University Affiliated Yangpu Hospital [Ye2202105]
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TAMs play a crucial role in tumorigenesis and malignant progression, and understanding their phenotype-switching is important for tumor therapy.
Tumour-associated macrophages (TAMs) have been found to be of great importance in tumorigenesis and in promoting malignant progression, including tumour angiogenesis and metastasis. Moreover, the TAM phenotype is more likely to be an M2 type. Transforming TAMs by M2-polarization into the tumour-suppressive M1 -phenotype is an important approach for tumour therapy. In this review, we analysed the effects of the tumour microenvironment on macrophage phenotype-switching, including hypoxia and cytokines, and the mechanisms of drugs targeting TAMs. Furthermore, we analysed the effects of exosomes on macrophage polarization, phenotype switching of macrophages, and the mechanisms of lipid mediators targeting TAMs.
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