PD-L1 up-regulation restrains Th17 cell differentiation in STAT3 loss- and STAT1 gain-of-function patients

Impaired natural killer cell functions in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations

(2017) Giovanna Tabellini et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

ERBIN deficiency links STAT3 and TGF-β pathway defects with atopy in humans

(2017) J.J. Lyons et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome

(2016) C. E. Bocchini et al.   BLOOD

Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype

(2016) J. Toubiana et al.   BLOOD

Ruxolitinib Induces Interleukin 17 and Ameliorates Chronic Mucocutaneous Candidiasis Caused by STAT1 Gain-of-Function Mutation

(2016) Rotraut Mössner et al.   CLINICAL INFECTIOUS DISEASES

Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC)

(2015) Jie Zheng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Use of ruxolitinib to successfully treat chronic mucocutaneous candidiasis caused by gain-of-function signal transducer and activator of transcription 1 (STAT1) mutation

(2015) Eleanor Higgins et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis

(2015) Yun Ling et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3

(2014) S. M. Steward-Tharp et al.   BLOOD

CX3CR1 Is Dispensable for Control of Mucosal Candida albicans Infections in Mice and Humans

(2014) Timothy J. Break et al.   INFECTION AND IMMUNITY

Oral-resident natural Th17 cells and γδ T cells control opportunisticCandida albicansinfections

(2014) Heather R. Conti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-  on STAT3 and Smads

(2014) K. Tanaka et al.   JOURNAL OF IMMUNOLOGY

The immune checkpoint inhibitors: where are we now?

(2014) Rachel M. Webster   NATURE REVIEWS DRUG DISCOVERY

The IL17A and IL17F loci have divergent histone modifications and are differentially regulated by prostaglandin E2 in Th17 cells

(2013) Juraj Adamik et al.   CYTOKINE

Gain-of-function STAT1 mutations are associated with PD-L1 overexpression and a defect in B-cell survival

(2013) Neil Romberg et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation of IL-17A Production Is Distinct from IL-17F in a Primary Human Cell Co-culture Model of T Cell-Mediated B Cell Activation

(2013) Andrew C. Melton et al.   PLoS One

Immunity to infection in IL-17-deficient mice and humans

(2012) Sophie Cypowyj et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-27 Priming of T Cells Controls IL-17 Production In trans via Induction of the Ligand PD-L1

(2012) Kiyoshi Hirahara et al.   IMMUNITY

Inborn Errors of Human JAKs and STATs

(2012) Jean-Laurent Casanova et al.   IMMUNITY

Cutting Edge: IL-17-Secreting Innate Lymphoid Cells Are Essential for Host Defense against Fungal Infection

(2012) A. Gladiator et al.   JOURNAL OF IMMUNOLOGY

Autosomal Dominant STAT3 Deficiency and Hyper-IgE Syndrome

(2012) Marie-Olivia Chandesris et al.   MEDICINE

Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile

(2012) Kenneth J Oestreich et al.   NATURE IMMUNOLOGY

Mouse model of oropharyngeal candidiasis

(2012) Norma V Solis et al.   Nature Protocols

Frequent and Widespread Vascular Abnormalities in Human Signal Transducer and Activator of Transcription 3 Deficiency

(2011) Marie-Olivia Chandesris et al.   Circulation-Cardiovascular Genetics

A Critical Role for STAT3 Transcription Factor Signaling in the Development and Maintenance of Human T Cell Memory

(2011) Andrea M. Siegel et al.   IMMUNITY

Heterozygous signal transducer and activator of transcription 3 mutations in hyper-IgE syndrome result in altered B-cell maturation

(2011) Almut Meyer-Bahlburg et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Gain-of-function humanSTAT1mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis

(2011) Luyan Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity

(2011) A. Puel et al.   SCIENCE

Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans

(2010) Shinobu Saijo et al.   IMMUNITY

B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

(2010) Danielle T. Avery et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intracranial aneurysms associated with hyperimmunoglobulinaemia E (Job) syndrome: report of two cases

(2010) A. R. Fathi et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Differential Expression of Interleukin-17A and -17F Is Coupled to T Cell Receptor Signaling via Inducible T Cell Kinase

(2009) Julio Gomez-Rodriguez et al.   IMMUNITY

Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses

(2009) Harumichi Ishigame et al.   IMMUNITY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced TH17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome

(2008) Ellen D. Renner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Deficiency of Th17 cells in hyper IgE syndrome due to mutations inSTAT3

(2008) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations inSTAT3andIL12RB1impair the development of human IL-17–producing T cells

(2008) Ludovic de Beaucoudrey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

(2008) Joshua D. Milner et al.   NATURE

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

(2007) Rosanne Spolski et al.   Annual Review of Immunology