Towards more drug-like proteomimetics: two-faced, synthetic α-helix mimetics based on a purine scaffold

Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions

(2015) Anna Barnard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereocontrolled protein surface recognition using chiral oligoamide proteomimetic foldamers

(2015) Valeria Azzarito et al.   Chemical Science

Structure-based design of small-molecule protein–protein interaction modulators: the story so far

(2014) Federico Falchi et al.   Future Medicinal Chemistry

Design, Solid-Phase Synthesis, and Evaluation of a Phenyl-Piperazine-Triazine Scaffold as α-Helix Mimetics

(2014) Heejo Moon et al.   ACS Combinatorial Science

α-Helix mimetics: Outwards and upwards

(2013) Madura K.P. Jayatunga et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Druggable protein–protein interactions – from hot spots to hot segments

(2013) Nir London et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Aromatic Oligoamide Foldamers with a “Wet Edge” as Inhibitors of the α-Helix-Mediated p53-hDM2 Protein-Protein Interaction

(2013) Panchami Prabhakaran et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Recapitulating the α-helix: nonpeptidic, low-molecular-weight ligands for the modulation of helix-mediated protein–protein interactions

(2013) Maryanna Lanning et al.   Future Medicinal Chemistry

Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease

(2013) Louisa CY Lee et al.   Future Medicinal Chemistry

The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein interactions with Bak

(2013) Xiaobo Cao et al.   Molecular Cancer

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Amphipathic α-Helix Mimetics Based on a 1,2-Diphenylacetylene Scaffold

(2013) Kwan-Young Jung et al.   ORGANIC LETTERS

Features of protein–protein interactions that translate into potent inhibitors: topology, surface area and affinity

(2012) Matthew C. Smith et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Amphiphilic α-helix mimetics based on a benzoylurea scaffold

(2012) Sam Thompson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors

(2012) Jeremy L. Yap et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Targeting Protein-Protein and Protein-Nucleic Acid Interactions for Anti-HIV Therapy

(2011) Mattia Mori et al.   CURRENT PHARMACEUTICAL DESIGN

Assessing Helical Protein Interfaces for Inhibitor Design

(2011) Brooke N. Bullock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Double-sided α-helix mimetics

(2011) Sam Thompson et al.   TETRAHEDRON

Disrupting protein–protein interactions with non-peptidic, small molecule α-helix mimetics

(2010) Christopher G Cummings et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Novel Pyrrolopyrimidine-Based α-Helix Mimetics: Cell-Permeable Inhibitors of Protein−Protein Interactions

(2010) Ji Hoon Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Concise access to N9-mono-, N2-mono- and N2,N9-di-substituted guanines via efficient Mitsunobu reactions

(2010) Steven Fletcher et al.   TETRAHEDRON

Protein-protein interaction networks and subnetworks in the biology of disease

(2010) Rod K. Nibbe et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Oligobenzamide proteomimetic inhibitors of the p53–hDM2 protein–protein interaction

(2009) Jeffrey P. Plante et al.   CHEMICAL COMMUNICATIONS

Novel Amphiphilic α-Helix Mimetics Based on a Bis-benzamide Scaffold

(2009) Srinivasa Marimganti et al.   ORGANIC LETTERS

Facile and efficient access to 2,6,9-tri-substituted purines through sequential N9, N2 Mitsunobu reactions

(2009) Steven Fletcher et al.   TETRAHEDRON LETTERS

BCL-2 family antagonists for cancer therapy

(2008) Guillaume Lessene et al.   NATURE REVIEWS DRUG DISCOVERY

Small Molecule Protein–Protein Interaction Inhibitors as CNS Therapeutic Agents: Current Progress and Future Hurdles

(2008) Levi L Blazer et al.   NEUROPSYCHOPHARMACOLOGY

Synthesis and Biological Evaluation of a 5-6-5 Imidazole-Phenyl-Thiazole Based α-Helix Mimetic

(2008) Christopher G. Cummings et al.   ORGANIC LETTERS