Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions

Direct Targeting of Rab-GTPase-Effector Interactions

(2014) Jochen Spiegel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The apoptotic pore on mitochondria: are we breaking through or still stuck?

(2014) C Borner et al.   CELL DEATH AND DIFFERENTIATION

Small-Molecule Proteomimetic Inhibitors of the HIF-1α-p300 Protein-Protein Interaction

(2014) George M. Burslem et al.   CHEMBIOCHEM

Modulators of Protein–Protein Interactions

(2014) Lech-Gustav Milroy et al.   CHEMICAL REVIEWS

Rational Design of Topographical Helix Mimics as Potent Inhibitors of Protein–Protein Interactions

(2014) Brooke Bullock Lao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Backbone modification of a polypeptide drug alters duration of action in vivo

(2014) Ross W Cheloha et al.   NATURE BIOTECHNOLOGY

Drugging the p53 pathway: understanding the route to clinical efficacy

(2014) Kian Hoe Khoo et al.   NATURE REVIEWS DRUG DISCOVERY

Orthogonal functionalisation of α-helix mimetics

(2014) Anna Barnard et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics

(2014) B. B. Lao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated  -synuclein

(2014) M. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many players in BCL-2 family affairs

(2014) Tudor Moldoveanu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Highly Functionalized Terpyridines as Competitive Inhibitors of AKAP-PKA Interactions

(2013) Gesa Schäfer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-Based Design of an RNA-Bindingp-Terphenylene Scaffold that Inhibits HIV-1 Rev Protein Function

(2013) Luis González-Bulnes et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Light-Regulated Stapled Peptides to Inhibit Protein-Protein Interactions Involved in Clathrin-Mediated Endocytosis

(2013) Laura Nevola et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anti-apoptosis Proteins Mcl-1 and Bcl-xL Have Different p53-Binding Profiles

(2013) Hongwei Yao et al.   BIOCHEMISTRY

The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein interactions with Bak

(2013) Xiaobo Cao et al.   Molecular Cancer

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Stapled peptide to enter human testing, but affinity questions remain

(2013) Yevgeniy Grigoryev   NATURE MEDICINE

Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development

(2013) Binh Vu et al.   ACS Medicinal Chemistry Letters

Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development

(2013) Zhuming Zhang et al.   ACS Medicinal Chemistry Letters

Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics

(2012) Kérya Long et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Aromatic Amide Foldamers: Structures, Properties, and Functions

(2012) Dan-Wei Zhang et al.   CHEMICAL REVIEWS

Synthetic foldamers

(2011) Gilles Guichard et al.   CHEMICAL COMMUNICATIONS

Assessing Helical Protein Interfaces for Inhibitor Design

(2011) Brooke N. Bullock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The BH3-mimetic GX15-070 induces autophagy, potentiates the cytotoxicity of carboplatin and 5-fluorouracil in esophageal carcinoma cells

(2010) Jingxuan Pan et al.   CANCER LETTERS

The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner

(2010) Aslamuzzaman Kazi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: assays and artifacts

(2010) Sandra Barth et al.   JOURNAL OF PATHOLOGY

Nutlin-3a Induces Cytoskeletal Rearrangement and Inhibits the Migration and Invasion Capacity of p53 Wild-Type Cancer Cells

(2010) Diarmuid M. Moran et al.   MOLECULAR CANCER THERAPEUTICS

N-alkylated oligoamide α-helical proteomimetics

(2010) Frederick Campbell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The p53 orchestra: Mdm2 and Mdmx set the tone

(2010) Mark Wade et al.   TRENDS IN CELL BIOLOGY

Synthetic α-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation

(2009) Ishu Saraogi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

(2009) Erinna F. Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cell-Permeable β-Peptide Inhibitors of p53/hDM2 Complexation

(2009) Elizabeth A. Harker et al.   CHEMBIOCHEM

α-Helix mimetics as inhibitors of protein–protein interactions

(2008) Ishu Saraogi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

(2008) S. Shangary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estimating the size of the human interactome

(2008) M. P. H. Stumpf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA