Aromatic Oligoamide Foldamers with a “Wet Edge” as Inhibitors of the α-Helix-Mediated p53-hDM2 Protein-Protein Interaction

Aromatic Amide Foldamers: Structures, Properties, and Functions

(2012) Dan-Wei Zhang et al.   CHEMICAL REVIEWS

Structural Biology and Drug Discovery of Difficult Targets: The Limits of Ligandability

(2012) Sachin Surade et al.   CHEMISTRY & BIOLOGY

Enaminone-Based Mimics of Extended and Hydrophilic α-Helices

(2012) Marc J. Adler et al.   CHEMISTRY-A EUROPEAN JOURNAL

Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors

(2012) Jeremy L. Yap et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

2-O-Alkylated para-benzamide α-helix mimetics: the role of scaffold curvature

(2012) Valeria Azzarito et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Helix-mediated protein–protein interactions as targets for intervention using foldamers

(2011) Thomas A. Edwards et al.   AMINO ACIDS

Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design

(2011) Erinna F. Lee et al.   CHEMBIOCHEM

Assessing Helical Protein Interfaces for Inhibitor Design

(2011) Brooke N. Bullock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An orthosteric inhibitor of the Ras-Sos interaction

(2011) Anupam Patgiri et al.   Nature Chemical Biology

Conformational properties of O-alkylated benzamides

(2011) Panchami Prabhakaran et al.   TETRAHEDRON

The p53-MDM2/MDMX axis – A chemotype perspective

(2011) Kareem Khoury et al.   MedChemComm

Structural Chemistry of Peptides Containing Backbone Expanded Amino Acid Residues: Conformational Features of β, γ, and Hybrid Peptides

(2010) Prema. G. Vasudev et al.   CHEMICAL REVIEWS

Disrupting protein–protein interactions with non-peptidic, small molecule α-helix mimetics

(2010) Christopher G Cummings et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Bridged β3-Peptide Inhibitors of p53-hDM2 Complexation: Correlation between Affinity and Cell Permeability

(2010) Arjel D. Bautista et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

(2010) Michelle L Stewart et al.   Nature Chemical Biology

N-alkylated oligoamide α-helical proteomimetics

(2010) Frederick Campbell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

12-Helix Folding of Cyclobutane β-Amino Acid Oligomers

(2010) Carlos Fernandes et al.   ORGANIC LETTERS

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

(2010) R. S. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-Permeable β-Peptide Inhibitors of p53/hDM2 Complexation

(2009) Elizabeth A. Harker et al.   CHEMBIOCHEM

Oligobenzamide proteomimetic inhibitors of the p53–hDM2 protein–protein interaction

(2009) Jeffrey P. Plante et al.   CHEMICAL COMMUNICATIONS

Inhibition of protein–protein interactions using designed molecules

(2009) Andrew J. Wilson   CHEMICAL SOCIETY REVIEWS

Hydrogen Bonding inortho-Substituted Arylamides: The Influence of Protic Solvents

(2009) Zhiwei Liu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Intramolecular Hydrogen Bonding inortho-Substituted Arylamide Oligomers: A Computational and Experimental Study ofortho-Fluoro- andortho-Chloro-N-methylbenzamides

(2009) Jhenny F. Galan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Design, Synthesis, and Evaluation of an α-Helix Mimetic Library Targeting Protein−Protein Interactions

(2009) Alex Shaginian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Novel Amphiphilic α-Helix Mimetics Based on a Bis-benzamide Scaffold

(2009) Srinivasa Marimganti et al.   ORGANIC LETTERS

β-Peptidic Peptidomimetics

(2008) Dieter Seebach et al.   ACCOUNTS OF CHEMICAL RESEARCH

Foldamers with Heterogeneous Backbones

(2008) W. Seth Horne et al.   ACCOUNTS OF CHEMICAL RESEARCH

Exploring β-Sheet Structure and Interactions with Chemical Model Systems

(2008) James S. Nowick   ACCOUNTS OF CHEMICAL RESEARCH

α-Helix mimetics as inhibitors of protein–protein interactions

(2008) Ishu Saraogi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Principles of Protein−Protein Interactions: What are the Preferred Ways For Proteins To Interact?

(2008) Ozlem Keskin et al.   CHEMICAL REVIEWS

Contemporary strategies for the stabilization of peptides in the α-helical conformation

(2008) Laura K Henchey et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Synthesis of an Oxazole–Pyrrole–Piperazine Scaffold as an α-Helix Mimetic

(2008) Lionel Moisan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of functionalised aromatic oligamide rods

(2007) Jeffrey Plante et al.   ORGANIC & BIOMOLECULAR CHEMISTRY