Features of protein–protein interactions that translate into potent inhibitors: topology, surface area and affinity

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop

(2012) Andreas B Schmid et al.   EMBO JOURNAL

Intrinsically disordered proteins and novel strategies for drug discovery

(2012) Vladimir N. Uversky   Expert Opinion on Drug Discovery

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

(2012) Jolanta Grembecka et al.   Nature Chemical Biology

Agonism/antagonism switching in allosteric ensembles

(2012) H. N. Motlagh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

(2012) T. Maurer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural biology and drug discovery for protein–protein interactions

(2012) Harry Jubb et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Macrocycles That Inhibit the Binding between Heat Shock Protein 90 and TPR-Containing Proteins

(2011) Veronica C. Ardi et al.   ACS Chemical Biology

Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism

(2011) Laura F. Silvian et al.   ACS Chemical Biology

Structure-Based Discovery of a Novel Inhibitor Targeting the β-Catenin/Tcf4 Interaction

(2011) Wang Tian et al.   BIOCHEMISTRY

The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

(2011) Jing Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hot Spots for Allosteric Regulation on Protein Surfaces

(2011) Kimberly A. Reynolds et al.   CELL

Interactome Networks and Human Disease

(2011) Marc Vidal et al.   CELL

Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition

(2011) Lisa von Kleist et al.   CELL

Insight into Amyloid Structure Using Chemical Probes

(2011) Ashley A. Reinke et al.   Chemical Biology & Drug Design

Chemical Screens against a Reconstituted Multiprotein Complex: Myricetin Blocks DnaJ Regulation of DnaK through an Allosteric Mechanism

(2011) Lyra Chang et al.   CHEMISTRY & BIOLOGY

Context-Based Identification of Protein-Protein Interfaces and “Hot-Spot” Residues

(2011) Tim Geppert et al.   CHEMISTRY & BIOLOGY

Branched Peptides for the Modulation of Protein-Protein Interactions: More Arms are Better than One?

(2011) M. Ruvo et al.   CURRENT MEDICINAL CHEMISTRY

Chemical and structural lessons from recent successes in protein–protein interaction inhibition (2P2I)

(2011) Xavier Morelli et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies

(2011) Yoshinari Miyata et al.   Future Medicinal Chemistry

Modulating Protein–Protein Interactions with Small Molecules: The Importance of Binding Hotspots

(2011) Ratna Rajesh Thangudu et al.   JOURNAL OF MOLECULAR BIOLOGY

An orthosteric inhibitor of the Ras-Sos interaction

(2011) Anupam Patgiri et al.   Nature Chemical Biology

Heat shock protein 70 kDa chaperone/DnaJ cochaperone complex employs an unusual dynamic interface

(2011) A. Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information

(2011) M. C. Good et al.   SCIENCE

Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors

(2010) Andrea L. Jochim et al.   ACS Chemical Biology

Binding of a Small Molecule at a Protein–Protein Interface Regulates the Chaperone Activity of Hsp70–Hsp40

(2010) Susanne Wisén et al.   ACS Chemical Biology

Nucleating the Assembly of Macromolecular Complexes

(2010) Kimberly J. Peterson-Kaufman et al.   CHEMBIOCHEM

Homodimeric Enzymes as Drug Targets

(2010) D. Cardinale et al.   CURRENT MEDICINAL CHEMISTRY

Enhancements of screening collections to address areas of unmet medical need: an industry perspective

(2010) David H Drewry et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy

(2010) James R Porter et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Discovery of Modulators of Protein-Protein Interactions: Current Approaches and Limitations

(2010) Lidio M.C. Meireles et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Transcriptional Switches: Chemical Approaches to Gene Regulation

(2010) Lori W. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATPases as Drug Targets: Insights from Heat Shock Proteins 70 and 90

(2010) Andrew J. Massey   JOURNAL OF MEDICINAL CHEMISTRY

Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target

(2010) Christopher G. Evans et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

(2010) Frauke Christ et al.   Nature Chemical Biology

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Atomic Analysis of Protein-Protein Interfaces with Known Inhibitors: The 2P2I Database

(2010) Raphaël Bourgeas et al.   PLoS One

Cellular strategies for the assembly of molecular machines

(2010) Ashwin Chari et al.   TRENDS IN BIOCHEMICAL SCIENCES

Computational Analysis of Protein Hotspots

(2010) Chao-Yie Yang et al.   ACS Medicinal Chemistry Letters

Amphipathic Small Molecules Mimic the Binding Mode and Function of Endogenous Transcription Factors

(2009) Sara J. Buhrlage et al.   ACS Chemical Biology

Molecular Mechanism of Inhibition of the Human Protein Complex Hsp90-Cdc37, a Kinome Chaperone-Cochaperone, by Triterpene Celastrol

(2009) Sridhar Sreeramulu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Atomic Interactions and Profile of Small Molecules Disrupting Protein-Protein Interfaces: the TIMBAL Database

(2009) Alícia P. Higueruelo et al.   Chemical Biology & Drug Design

The road less traveled: modulating signal transduction enzymes by inhibiting their protein–protein interactions

(2009) Michelle R Arkin et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Alternate Strategies of Hsp90 Modulation for the Treatment of Cancer and Other Diseases

(2009) Gary Brandt et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Pharmacological Targeting of the Hsp70 Chaperone

(2009) Srikanth Patury et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Characterization of Celastrol to Inhibit Hsp90 and Cdc37 Interaction

(2009) Tao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Affinities between the Binding Partners of the HIV-1 Integrase Dimer-Lens Epithelium-derived Growth Factor (IN Dimer-LEDGF) Complex

(2009) Manuel Tsiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Covalent Modifiers: An Orthogonal Approach to Drug Design

(2009) Michele H. Potashman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allostery in Hsp70 Chaperones Is Transduced by Subdomain Rotations

(2009) Akash Bhattacharya et al.   JOURNAL OF MOLECULAR BIOLOGY

Identifying Modulators of Protein−Protein Interactions Using Photonic Crystal Biosensors

(2009) James T. Heeres et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

(2009) J. I-Ju Leu et al.   MOLECULAR CELL

A synergistic small-molecule combination directly eradicates diverse prion strain structures

(2009) Blake E Roberts et al.   Nature Chemical Biology

The rise of fragment-based drug discovery

(2009) Christopher W. Murray et al.   Nature Chemistry

Converging concepts of protein folding in vitro and in vivo

(2009) F Ulrich Hartl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Trapping Moving Targets with Small Molecules

(2009) G. M. Lee et al.   SCIENCE

A Novel Class of Small Molecule Inhibitors of Hsp90

(2008) Fang Yi et al.   ACS Chemical Biology

Expanding the repertoire of small molecule transcriptional activation domains

(2008) Ryan J. Casey et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Principles of Protein−Protein Interactions: What are the Preferred Ways For Proteins To Interact?

(2008) Ozlem Keskin et al.   CHEMICAL REVIEWS

Novobiocin and Additional Inhibitors of the Hsp90 C-Terminal Nucleotide- binding Pocket

(2008) Alison Donnelly et al.   CURRENT MEDICINAL CHEMISTRY

The Human Cdc37·Hsp90 Complex Studied by Heteronuclear NMR Spectroscopy

(2008) Sridhar Sreeramulu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cell-penetrating Helical Peptide as a Potential HIV-1 Inhibitor

(2008) Hongtao Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

From hatching to dispatching: the multiple cellular roles of the Hsp70 molecular chaperone machinery

(2008) Eirini Meimaridou et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

A General and Rapid Cell-Free Approach for the Interrogation of Protein−Protein, Protein−DNA, and Protein−RNA Interactions and their Antagonists Utilizing Split-Protein Reporters

(2008) Jason R. Porter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural identification of the pathway of long-range communication in an allosteric enzyme

(2008) P. S. Gandhi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

(2008) S. Shangary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK

(2007) Lyra Chang et al.   ANALYTICAL BIOCHEMISTRY