G-quadruplexes: targets and tools in anticancer drug design

Telomere Maintenance as Therapeutic Target in Embryonal Tumours

(2012) T. Shalaby et al.   Anti-Cancer Agents in Medicinal Chemistry

The guanine-quadruplex aptamer 93del inhibits HIV-1 replication ex vivo by interfering with viral entry, reverse transcription and integration

(2011) Aurélie Faure-Perraud et al.   ANTIVIRAL THERAPY

Targeting pancreatic cancer with a G-quadruplex ligand

(2011) Mekala Gunaratnam et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of nonplanar small molecule for G-quadruplex grooves: Molecular docking and molecular dynamic study

(2011) Jinlian Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel Modular DNA Aptamer for Human Thrombin with High Anticoagulant Activity

(2011) E. Zavyalova et al.   CURRENT MEDICINAL CHEMISTRY

G-quadruplex-induced instability during leading-strand replication

(2011) Judith Lopes et al.   EMBO JOURNAL

Demonstration that Drug-targeted Down-regulation of MYC in Non-Hodgkins Lymphoma Is Directly Mediated through the Promoter G-quadruplex

(2011) Robert V. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Telomeric RNA Quadruplex−Acridine Ligand Recognition

(2011) Gavin W. Collie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Telomere Targeting with a New G4 Ligand Enhances Radiation-Induced Killing of Human Glioblastoma Cells

(2011) P. Merle et al.   MOLECULAR CANCER THERAPEUTICS

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

(2011) Peter Sarkies et al.   NUCLEIC ACIDS RESEARCH

The DEAH-box RNA helicase RHAU binds an intramolecular RNA G‐quadruplex in TERC and associates with telomerase holoenzyme

(2011) Simon Lattmann et al.   NUCLEIC ACIDS RESEARCH

Yin Yang 1 contains G-quadruplex structures in its promoter and 5′-UTR and its expression is modulated by G4 resolvase 1

(2011) Weiwei Huang et al.   NUCLEIC ACIDS RESEARCH

A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro

(2011) Eun-Ang Raiber et al.   NUCLEIC ACIDS RESEARCH

Research Progress of RNA Quadruplex

(2011) Xiaohui Ji et al.   Nucleic Acid Therapeutics

Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity

(2010) Cyril M. Sanders   BIOCHEMICAL JOURNAL

Remarkable interference with telomeric function by a G-quadruplex selective bisantrene regioisomer

(2010) Marco Folini et al.   BIOCHEMICAL PHARMACOLOGY

Selective Targeting of G-Quadruplex Using Furan-Based Cyclic Homooligopeptides: Effect on c-MYC Expression

(2010) Tani Agarwal et al.   BIOCHEMISTRY

The C-Terminus of Nucleolin Promotes the Formation of the c-MYCG-Quadruplex and Inhibits c-MYCPromoter Activity

(2010) Verónica González et al.   BIOCHEMISTRY

TheBCL-25′ Untranslated Region Contains an RNA G-Quadruplex-Forming Motif That Modulates Protein Expression

(2010) Ramla Shahid et al.   BIOCHEMISTRY

Bisaryldiketene derivatives: A new class of selective ligands for c-myc G-quadruplex DNA

(2010) Dan Peng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity

(2010) Mavurapu Satyanarayana et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exon Array Analyses across the NCI-60 Reveal Potential Regulation of TOP1 by Transcription Pausing at Guanosine Quartets in the First Intron

(2010) W. C. Reinhold et al.   CANCER RESEARCH

A New Paradigm for Aptamer Therapeutic AS1411 Action: Uptake by Macropinocytosis and Its Stimulation by a Nucleolin-Dependent Mechanism

(2010) E. M. Reyes-Reyes et al.   CANCER RESEARCH

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

(2010) Denis Drygin et al.   CANCER RESEARCH

G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms

(2010) Virginie Marcel et al.   CARCINOGENESIS

Structure-Based Design of Platinum(II) Complexes as c-myc Oncogene Down-Regulators and Luminescent Probes for G-Quadruplex DNA

(2010) Ping Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Telomerase structure function

(2010) Mark Mason et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Making sense of G-quadruplex and i-motif functions in oncogene promoters

(2010) Tracy A. Brooks et al.   FEBS Journal

G-quadruplex nucleic acids and human disease

(2010) Yuliang Wu et al.   FEBS Journal

TERRA biogenesis, turnover and implications for function

(2010) Sascha Feuerhahn et al.   FEBS LETTERS

Macrocyclic Pyridyl Polyoxazoles: Selective RNA and DNA G-Quadruplex Ligands as Antitumor Agents

(2010) Suzanne G. Rzuczek et al.   JOURNAL OF MEDICINAL CHEMISTRY

Coexistence of Two Distinct G-Quadruplex Conformations in the hTERT Promoter

(2010) Kah Wai Lim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Water Soluble Cationic Perylene Derivatives as Possible Telomerase Inhibitors: The Search for Selective G-Quadruplex Targeting

(2010) Emanuela Michelia et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Disabling c-Myc in Childhood Medulloblastoma and Atypical Teratoid/Rhabdoid Tumor Cells by the Potent G-Quadruplex Interactive Agent S2T1-6OTD

(2010) T. Shalaby et al.   MOLECULAR CANCER THERAPEUTICS

Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU

(2010) Simon Lattmann et al.   NUCLEIC ACIDS RESEARCH

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

(2010) Sophie Redon et al.   NUCLEIC ACIDS RESEARCH

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer

(2010) Anna Pasternak et al.   NUCLEIC ACIDS RESEARCH

A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex

(2010) Gavin W. Collie et al.   NUCLEIC ACIDS RESEARCH

Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter

(2010) Vitaly Kuryavyi et al.   NUCLEIC ACIDS RESEARCH

Inducement of G-Quadruplex DNA Forming and Down-Regulation of OncogeneC-MYCby Bile Acid-Amino Acid Conjugate—BAA

(2010) Mingyue Tian et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

(2010) E Salvati et al.   ONCOGENE

Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex

(2010) Anthony Bugaut et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Telomeric repeat-containing RNA structure in living cells

(2010) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Unusually Stable G-Quadruplex within the 5′-UTR of the MT3 Matrix Metalloproteinase mRNA Represses Translation in Eukaryotic Cells

(2009) Mark J. Morris et al.   BIOCHEMISTRY

Repression of Translation of Human Estrogen Receptor α by G-Quadruplex Formation

(2009) Graham D. Balkwill et al.   BIOCHEMISTRY

Characterization of a K+-Induced Conformational Switch in a Human Telomeric DNA Oligonucleotide Using 2-Aminopurine Fluorescence

(2009) Robert D. Gray et al.   BIOCHEMISTRY

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes

(2009) Gavin Collie et al.   CHEMICAL COMMUNICATIONS

Nucleic Acid Aptamers Based on the G-Quadruplex Structure: Therapeutic and Diagnostic Potential

(2009) B. Gatto et al.   CURRENT MEDICINAL CHEMISTRY

The structures of quadruplex nucleic acids and their drug complexes

(2009) Stephen Neidle   CURRENT OPINION IN STRUCTURAL BIOLOGY

Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer

(2009) Paula J. Bates et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Antitumor activity of TMPyP4 interacting G-quadruplex in retinoblastoma cell lines

(2009) Yoko Mikami-Terao et al.   EXPERIMENTAL EYE RESEARCH

Human telomeric G-quadruplex: structures of DNA and RNA sequences

(2009) Anh Tuân Phan   FEBS Journal

Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer

(2009) Stephen Neidle   FEBS Journal

Identification and Characterization of Nucleolin as a c-mycG-quadruplex-binding Protein

(2009) Verónica González et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of a Unique End-to-End Stacked Pair of G-Quadruplexes in the hTERT Core Promoter with Implications for Inhibition of Telomerase by G-Quadruplex-Interactive Ligands

(2009) SunMi L. Palumbo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the Human Telomere in K+Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers

(2009) Kah Wai Lim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Plasma Membrane Nucleolin Is a Receptor for the Anticancer Aptamer AS1411 in MV4-11 Leukemia Cells

(2009) S. Soundararajan et al.   MOLECULAR PHARMACOLOGY

G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth

(2009) Yongli Guan et al.   MOLECULAR THERAPY

Cancer-selective antiproliferative activity is a general property of some G-rich oligodeoxynucleotides

(2009) Enid W. Choi et al.   NUCLEIC ACIDS RESEARCH

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

(2009) Angela Rizzo et al.   NUCLEIC ACIDS RESEARCH

Evidence of genome-wide G4 DNA-mediated gene expression in human cancer cells

(2009) Anjali Verma et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex structures: in vivo evidence and function

(2009) Hans J. Lipps et al.   TRENDS IN CELL BIOLOGY

Position and Stability Are Determining Factors for Translation Repression by an RNA G-Quadruplex-Forming Sequence within the 5′ UTR of theNRASProto-oncogene†

(2008) Sunita Kumari et al.   BIOCHEMISTRY

Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions

(2008) Yong Qin et al.   BIOCHIMIE

Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives

(2008) Hsu-Shan Huang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Nucleolin Targeting Aptamer AS1411 Destabilizes Bcl-2 Messenger RNA in Human Breast Cancer Cells

(2008) S. Soundararajan et al.   CANCER RESEARCH

G-Quadruplex Ligand RHPS4 Potentiates the Antitumor Activity of Camptothecins in Preclinical Models of Solid Tumors

(2008) C. Leonetti et al.   CLINICAL CANCER RESEARCH

Platination of telomeric sequences and nuclease hypersensitive elements of human c-myc and PDGF-A promoters and their ability to form G-quadruplexes

(2008) Viktor Viglasky   FEBS Journal

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G4 Resolvase 1 Binds Both DNA and RNA Tetramolecular Quadruplex with High Affinity and Is the Major Source of Tetramolecular Quadruplex G4-DNA and G4-RNA Resolving Activity in HeLa Cell Lysates

(2008) Steven D. Creacy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents

(2008) D. Sun et al.   MOLECULAR CANCER THERAPEUTICS

A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity

(2008) SunMi L. Palumbo et al.   NUCLEIC ACIDS RESEARCH

G-Rich Oligonucleotides Alter Cell Cycle Progression and Induce Apoptosis Specifically in OE19 Esophageal Tumor Cells

(2008) Timothy R. Schwartz et al.   OLIGONUCLEOTIDES

Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif

(2008) A. Arora et al.   RNA

Genome-wide analysis reveals regulatory role of G4 DNA in gene transcription

(2007) Z. Du et al.   GENOME RESEARCH