Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer

Thermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides

(2010) Anna Pasternak et al.   NUCLEIC ACIDS RESEARCH

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

(2010) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

UNA (unlocked nucleic acid): A flexible RNA mimic that allows engineering of nucleic acid duplex stability

(2009) Niels Langkjær et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Conformation and thermostability of oligonucleotide d(GGTTGGTGTGGTTGG) containing thiophosphoryl internucleotide bonds at different positions

(2009) Marina Zaitseva et al.   BIOPHYSICAL CHEMISTRY

Biaryl polyamides as a new class of DNA quadruplex-binding ligands

(2009) Khondaker M. Rahman et al.   CHEMICAL COMMUNICATIONS

G-quadruplex nucleic acids as therapeutic targets

(2009) Shankar Balasubramanian et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Combinatorial Synthesis of Thrombin-Binding Aptamers Containing iso-Guanine

(2009) Subba Rao Nallagatla et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4′-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer

(2009) Kees Fluiter et al.   Molecular BioSystems

Unique quadruplex structure and interaction of an RNA aptamer against bovine prion protein

(2009) T. Mashima et al.   NUCLEIC ACIDS RESEARCH

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

(2009) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

In vivo veritas: Using yeast to probe the biological functions of G-quadruplexes

(2008) Jay E. Johnson et al.   BIOCHIMIE

Synthesis, structural studies and biological properties of new TBA analogues containing an acyclic nucleotide

(2008) Teresa Coppola et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes

(2008) Julian Leon Huppert   CHEMICAL SOCIETY REVIEWS

G-Quadruplexes: Targets in Anticancer Drug Design

(2008) Tian-miao Ou et al.   ChemMedChem

Effect of Locked-Nucleic Acid on a Biologically Active G-Quadruplex. A Structure-Activity Relationship of the Thrombin Aptamer

(2008) Laura Bonifacio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

G-Quadruplex Formation by Human Telomeric Repeats-Containing RNA in Na+Solution

(2008) Yan Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

4-Thio-deoxyuridylate-modified thrombin aptamer and its inhibitory effect on fibrin clot formation, platelet aggregation and thrombus growth on subendothelial matrix

(2008) S. MENDELBOUM RAVIV et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives

(2007) Giuseppe Zagotto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Stability and Binding Properties of a Modified Thrombin Binding Aptamer

(2007) Bruno Pagano et al.   BIOPHYSICAL JOURNAL