5′-Adenosine monophosphate-activated protein kinase: A potential target for disease prevention by curcumin

Curcumin: A natural modulator of immune cells in systemic lupus erythematosus

(2018) Amir Abbas Momtazi-Borojeni et al.   AUTOIMMUNITY REVIEWS

Current status and future prospective of Curcumin as a potential therapeutic agent in the treatment of colorectal cancer

(2018) Mohammad Jalili-Nik et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Curcumin, quercetin and atorvastatin protected against the hepatic fibrosis by activating AMP-activated protein kinase

(2018) Razieh Kabirifar et al.   Journal of Functional Foods

Therapeutic potency of mTOR signaling pharmacological inhibitors in the treatment of proinflammatory diseases, current status, and perspectives

(2017) Arash Soltani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Curcumin, hemostasis, thrombosis, and coagulation

(2017) Faeze Keihanian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Therapeutic effects of curcumin in inflammatory and immune-mediated diseases: A nature-made jack-of-all-trades?

(2017) Elham Abdollahi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel

(2017) Arrigo F G Cicero et al.   NUTRITION REVIEWS

Curcumin use in pulmonary diseases: State of the art and future perspectives

(2017) Diana Lelli et al.   PHARMACOLOGICAL RESEARCH

The role of curcumin in disruption of HIF-1α accumulation to alleviate adipose fibrosis via AMPK-mediated mTOR pathway in high-fat diet fed mice

(2017) Zhixia Qiu et al.   Journal of Functional Foods

Sesn2/AMPK/mTOR signaling mediates balance between survival and apoptosis in sensory hair cells under stress

(2017) Daniel Bodmer et al.   Cell Death & Disease

Dissecting the role of AMP-activated protein kinase in human diseases

(2017) Jin Li et al.   Acta Pharmaceutica Sinica B

Curcumin: A new candidate for melanoma therapy?

(2016) Hamed Mirzaei et al.   INTERNATIONAL JOURNAL OF CANCER

Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate-activated protein kinase

(2016) Naqi Lian et al.   IUBMB LIFE

Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease

(2016) Yunes Panahi et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Curcumin induces brown fat-like phenotype in 3T3-L1 and primary white adipocytes

(2016) Jameel Lone et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Consequences of AMPK activation

(2016) Claire Greenhill   Nature Reviews Endocrinology

Lipid-modifying effects of nutraceuticals: An evidence-based approach

(2016) Amirhossein Sahebkar et al.   NUTRITION

Curcumin downregulates human tumor necrosis factor-α levels: A systematic review and meta-analysis ofrandomized controlled trials

(2016) Amirhossein Sahebkar et al.   PHARMACOLOGICAL RESEARCH

Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial

(2016) Sepideh Rahmani et al.   PHYTOTHERAPY RESEARCH

Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF–κB, uPA activator and MMP9

(2016) Weihua Tong et al.   Oncology Letters

The effect of dietary curcumin and capsaicin on hepatic fetuin-A expression and fat accumulation in rats fed on a high-fat diet

(2016) Muhammed Seyithanoğlu et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial

(2016) Yunes Panahi et al.   INFLAMMOPHARMACOLOGY

Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis

(2015) Yunes Panahi et al.   CLINICAL NUTRITION

Curcumin Enhanced Cholesterol Efflux by Upregulating ABCA1 Expression Through AMPK-SIRT1-LXRα Signaling in THP-1 Macrophage-Derived Foam Cells

(2015) Xiao-long Lin et al.   DNA AND CELL BIOLOGY

Curcumin regulates peroxisome proliferator-activated receptor-γ coactivator-1α expression by AMPK pathway in hepatic stellate cells in vitro

(2015) Xuguang Zhai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effect of curcumin (Curcuma longa extract) on LPS-induced acute lung injury is mediated by the activation of AMPK

(2015) Joungmin Kim et al.   Journal of Anesthesia

Curcumin inhibits Ec109 cell growth via an AMPK-mediated metabolic switch

(2015) Feng-Juan Zhang et al.   LIFE SCIENCES

Anti-inflammatory therapies for atherosclerosis

(2015) Magnus Bäck et al.   Nature Reviews Cardiology

Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK

(2015) Ying Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Curcumin, a component of golden spice: From bedside to bench and back

(2014) Sahdeo Prasad et al.   BIOTECHNOLOGY ADVANCES

Lipid-modifying effects of adjunctive therapy with curcuminoids–piperine combination in patients with metabolic syndrome: Results of a randomized controlled trial

(2014) Yunes Panahi et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages

(2014) Jiatian Cao et al.   Journal of Translational Medicine

A PPARγ, NF-κB and AMPK-Dependent Mechanism May Be Involved in the Beneficial Effects of Curcumin in the Diabetic db/db Mice Liver

(2014) Lizbeth Jiménez-Flores et al.   MOLECULES

Investigation of the Efficacy of Adjunctive Therapy with Bioavailability-Boosted Curcuminoids in Major Depressive Disorder

(2014) Yunes Panahi et al.   PHYTOTHERAPY RESEARCH

Adjuvant Therapy with Bioavailability-Boosted Curcuminoids Suppresses Systemic Inflammation and Improves Quality of Life in Patients with Solid Tumors: A Randomized Double-Blind Placebo-Controlled Trial

(2014) Yunes Panahi et al.   PHYTOTHERAPY RESEARCH

Investigation of the Effects of Curcumin on Serum Cytokines in Obese Individuals: A Randomized Controlled Trial

(2014) Shiva Ganjali et al.   TheScientificWorldJOURNAL

Hitting the Golden TORget: Curcumin’s Effects on mTOR Signaling

(2013) Christopher Beevers et al.   Anti-Cancer Agents in Medicinal Chemistry

Curcumin Attenuates Diet-Induced Hepatic Steatosis by Activating AMP-Activated Protein Kinase

(2013) Min Young Um et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Curcumin and obesity

(2013) Peter G. Bradford   BIOFACTORS

Molecular mechanisms of hypolipidemic effects of curcumin

(2013) Jean-Marc Zingg et al.   BIOFACTORS

Demethoxycurcumin Inhibits Energy Metabolic and Oncogenic Signaling Pathways through AMPK Activation in Triple-Negative Breast Cancer Cells

(2013) Jiunn-Min Shieh et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

Curcumin Induces Autophagy via Activating the AMPK Signaling Pathway in Lung Adenocarcinoma Cells

(2013) Kui Xiao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Are Curcuminoids Effective C-Reactive Protein-Lowering Agents in Clinical Practice? Evidence from a Meta-Analysis

(2013) Amirhossein Sahebkar   PHYTOTHERAPY RESEARCH

Demethoxycurcumin Modulates Prostate Cancer Cell Proliferation via AMPK-Induced Down-regulation of HSP70 and EGFR

(2012) Chao-Ming Hung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Curcumin decreases renal triglyceride accumulation through AMPK–SREBP signaling pathway in streptozotocin-induced type 1 diabetic rats

(2012) Vivian Soetikno et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial

(2012) Li-Xin Na et al.   MOLECULAR NUTRITION & FOOD RESEARCH

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effects of Supplementation with Curcuminoids on Dyslipidemia in Obese Patients: A Randomized Crossover Trial

(2012) Akram Mohammadi et al.   PHYTOTHERAPY RESEARCH

A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications

(2012) Y. Panahi et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Sensing of energy and nutrients by AMP-activated protein kinase

(2011) D Grahame Hardie   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effects of valproate on Tax and HBZ expression in HTLV-1 and HAM/TSP T lymphocytes

(2011) G. Belrose et al.   BLOOD

Long-term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism

(2011) Su-Kyung Shin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Multitargeting by curcumin as revealed by molecular interaction studies

(2011) Subash C. Gupta et al.   NATURAL PRODUCT REPORTS

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Effect of Different Curcuminoid Supplement Dosages on TotalIn VivoAntioxidant Capacity and Cholesterol Levels of Healthy Human Subjects

(2011) Kanit Pungcharoenkul et al.   PHYTOTHERAPY RESEARCH

Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice

(2010) Konstantin Tsoyi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Curcumin Protects Hepatic Stellate Cells against Leptin-Induced Activationin Vitroby Accumulating Intracellular Lipids

(2010) Youcai Tang et al.   ENDOCRINOLOGY

Synergistic effect of curcumin and insulin on muscle cell glucose metabolism

(2010) Changkeun Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

Pathogenesis of Insulin Resistance in Skeletal Muscle

(2010) Muhammad A. Abdul-Ghani et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Regulatory Effect of the AMPK-COX-2 Signaling Pathway in Curcumin-Induced Apoptosis in HT-29 Colon Cancer Cells

(2009) Yun-Kyoung Lee et al.   Annals of the New York Academy of Sciences

Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells

(2009) Teayoun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Non-CDK-bound p27 (p27NCDK) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways

(2009) Mia A. Björklund et al.   EXPERIMENTAL CELL RESEARCH

Metformin Attenuated the Autoimmune Disease of the Central Nervous System in Animal Models of Multiple Sclerosis

(2009) N. Nath et al.   JOURNAL OF IMMUNOLOGY

Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo

(2009) M. Iranshahi et al.   PHYTOMEDICINE

mTOR and HIF-1 -mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

(2009) D. B. Shackelford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

(2008) Kei Sakamoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins

(2008) Ajaikumar B. Kunnumakkara et al.   CANCER LETTERS

Curcumin inhibits glucose production in isolated mice hepatocytes

(2008) Hideya Fujiwara et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Curcumin Exerts Antidifferentiation Effect through AMPKα-PPAR-γ in 3T3-L1 Adipocytes and Antiproliferatory Effect through AMPKα-COX-2 in Cancer Cells

(2008) Yun K. Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism

(2008) S. Yu et al.   MOLECULAR CANCER THERAPEUTICS