Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 233, Issue 6, Pages 4783-4790Publisher
WILEY
DOI: 10.1002/jcp.26276
Keywords
inflammation; inflamatory diseases; mammalian target of rapamycin; pharmacological inhibitors
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Funding
- Mashhad University of Medical Sciences [951824]
- Iran National Science Foundation [96006612]
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Mammalian target of rapamycin (mTOR) signaling pathway controls cell energy metabolism. There is an interplay between mTOR and proinflammatory signaling pathways, supporting the role of the pathway in the pathogenesis of inflammatory diseases. Inhibition of mTOR signaling using specific pharmacological inhibitors could offer therapeutic promise in several inflammatory-associated diseases. In this review, we summarize recent findings on the regulatory effects of mTOR signaling on inflammation and the therapeutic potency of mTOR pharmacological inhibitors in the treatment of inflammatory diseases including cancer, neurodegenerative diseases, atherosclerosis, sepsis, and rheumatoid arthritis for a better understanding and hence a better management of these diseases.
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