Molecular Mechanisms of Osteoblast/Osteocyte Regulation by Connexin43

Spatiotemporal properties of intracellular calcium signaling in osteocytic and osteoblastic cell networks under fluid flow

(2013) Da Jing et al.   BONE

ERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts

(2012) Corinne Niger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of connexin 43 in the mechanism of action of alendronate: Dissociation of anti-apoptotic and proliferative signaling pathways

(2012) V. Lezcano et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors

(2012) D. Gonzalez-Nieto et al.   BLOOD

Bisphosphonates improve trabecular bone mass and normalize cortical thickness in ovariectomized, osteoblast connexin43 deficient mice

(2012) Marcus P. Watkins et al.   BONE

In situ imaging of the autonomous intracellular Ca2+ oscillations of osteoblasts and osteocytes in bone

(2012) Yoshihito Ishihara et al.   BONE

Osteocyte apoptosis

(2012) Robert L. Jilka et al.   BONE

Ex vivo real-time observation of Ca2+ signaling in living bone in response to shear stress applied on the bone surface

(2012) Yoshihito Ishihara et al.   BONE

Beyond gap junctions: Connexin43 and bone cell signaling

(2012) Lilian I. Plotkin et al.   BONE

In vitro and in vivo approaches to study osteocyte biology

(2012) Ivo Kalajzic et al.   BONE

Deletion of Cx43 from Osteocytes Results in Defective Bone Material Properties but Does Not Decrease Extrinsic Strength in Cortical Bone

(2012) Nicoletta Bivi et al.   CALCIFIED TISSUE INTERNATIONAL

Semaphorin3d mediates Cx43-dependent phenotypes during fin regeneration

(2012) Quynh V. Ton et al.   DEVELOPMENTAL BIOLOGY

Determining how defects in connexin43 cause skeletal disease

(2012) Quynh V. Ton et al.   GENESIS

Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading

(2012) Shane A Lloyd et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Connexin43 and Pannexin1 Channels in Osteoblasts: Who Is the “Hemichannel”?

(2012) Mia M. Thi et al.   JOURNAL OF MEMBRANE BIOLOGY

Enhanced Periosteal and Endocortical Responses to Axial Tibial Compression Loading in Conditional Connexin43 Deficient Mice

(2012) Susan K. Grimston et al.   PLoS One

Mechanical stress-activated integrin  5 1 induces opening of connexin 43 hemichannels

(2012) N. Batra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gap junctional channels are parts of multiprotein complexes

(2011) Jean-Claude Hervé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The transcriptional activity of osterix requires the recruitment of Sp1 to the osteocalcin proximal promoter

(2011) Corinne Niger et al.   BONE

Pannexin channels are not gap junction hemichannels

(2011) Gina E. Sosinsky et al.   Channels

Connexin43 deficiency reduces the sensitivity of cortical bone to the effects of muscle paralysis

(2011) Susan K Grimston et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes

(2011) Stephen R Bond et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cell autonomous requirement of connexin 43 for osteocyte survival: Consequences for endocortical resorption and periosteal bone formation

(2011) Nicoletta Bivi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pannexin 3 functions as an ER Ca2+channel, hemichannel, and gap junction to promote osteoblast differentiation

(2011) Masaki Ishikawa et al.   JOURNAL OF CELL BIOLOGY

Connexin43 interacts with βarrestin: A pre-requisite for osteoblast survival induced by parathyroid hormone

(2011) Nicoletta Bivi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Osteoblast connexin43 modulates skeletal architecture by regulating both arms of bone remodeling

(2011) Marcus Watkins et al.   MOLECULAR BIOLOGY OF THE CELL

CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions

(2011) Amir Schajnovitz et al.   NATURE IMMUNOLOGY

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Enhanced Osteoclastic Resorption and Responsiveness to Mechanical Load in Gap Junction Deficient Bone

(2011) Yue Zhang et al.   PLoS One

Interaction of connexin43 and protein kinase C-delta during FGF2 signaling

(2010) Corinne Niger et al.   BMC BIOCHEMISTRY

Novel actions of bisphosphonates in bone: Preservation of osteoblast and osteocyte viability

(2010) Teresita Bellido et al.   BONE

An ATP-dependent mechanism mediates intercellular calcium signaling in bone cell network under single cell nanoindentation

(2010) Bo Huo et al.   CELL CALCIUM

Pannexin channels in ATP release and beyond: An unexpected rendezvous at the endoplasmic reticulum

(2010) Catheleyne D'hondt et al.   CELLULAR SIGNALLING

Intercellular calcium wave propagation in linear and circuit-like bone cell networks

(2010) B. Huo et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Pannexins, distant relatives of the connexin family with specific cellular functions?

(2009) Catheleyne D'hondt et al.   BIOESSAYS

Identification of differentially expressed genes between osteoblasts and osteocytes

(2009) Frane Paic et al.   BONE

GJA1mutations, variants, and connexin 43 dysfunction as it relates to the oculodentodigital dysplasia phenotype

(2009) William A. Paznekas et al.   HUMAN MUTATION

FGF2-activated ERK Mitogen-activated Protein Kinase Enhances Runx2 Acetylation and Stabilization

(2009) Ok-Jin Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin43 Potentiates Osteoblast Responsiveness to Fibroblast Growth Factor 2 via a Protein Kinase C-Delta/Runx2–dependent Mechanism

(2009) Florence Lima et al.   MOLECULAR BIOLOGY OF THE CELL

Cell–cell communication in the osteoblast/osteocyte lineage

(2008) Roberto Civitelli   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Aminobisphosphonates Cause Osteoblast Apoptosis and Inhibit Bone Nodule Formation In Vitro

(2008) Aymen I. Idris et al.   CALCIFIED TISSUE INTERNATIONAL

Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration

(2008) Angela D. Hoptak-Solga et al.   DEVELOPMENTAL BIOLOGY

Connexin43 regulates joint location in zebrafish fins

(2008) Kenneth Sims et al.   DEVELOPMENTAL BIOLOGY

Adaptation of Connexin 43-Hemichannel Prostaglandin Release to Mechanical Loading

(2008) Arlene J. Siller-Jackson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin 43 Is Required for the Anti-Apoptotic Effect of Bisphosphonates on Osteocytes and Osteoblasts In Vivo

(2008) Lilian I Plotkin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

ODDD-Linked Cx43 Mutants Reduce Endogenous Cx43 Expression and Function in Osteoblasts and Inhibit Late Stage Differentiation

(2008) Elizabeth McLachlan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Attenuated Response to In Vivo Mechanical Loading in Mice With Conditional Osteoblast Ablation of the Connexin43 Gene (Gja1)

(2008) Susan K Grimston et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Functional Gap Junctions Between Osteocytic and Osteoblastic Cells

(2006) Clare E. Yellowley et al.   JOURNAL OF BONE AND MINERAL RESEARCH