A Systems Biology Analysis of Apoptosome Formation and Apoptosis Execution Supports Allosteric Procaspase-9 Activation

From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine

(2014) M L Würstle et al.   Cell Death & Disease

Systems biology of death receptor networks: live and let die

(2014) I N Lavrik   Cell Death & Disease

Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells

(2013) E Passante et al.   CELL DEATH AND DIFFERENTIATION

Apoptosome Structure, Assembly, and Procaspase Activation

(2013) Shujun Yuan et al.   STRUCTURE

Activation of executioner caspases is a predictor of progression-free survival in glioblastoma patients: a systems medicine approach

(2013) Á C Murphy et al.   Cell Death & Disease

Rsk-mediated phosphorylation and 14-3-3ε binding of Apaf-1 suppresses cytochromec-induced apoptosis

(2012) Jiyeon Kim et al.   EMBO JOURNAL

The central role of initiator caspase-9 in apoptosis signal transduction and the regulation of its activation and activity on the apoptosome

(2012) Maximilian L. Würstle et al.   EXPERIMENTAL CELL RESEARCH

The ‘complexities’ of life and death: Death receptor signalling platforms

(2012) Laura S. Dickens et al.   EXPERIMENTAL CELL RESEARCH

Systems Analysis of Cancer Cell Heterogeneity in Caspase-dependent Apoptosis Subsequent to Mitochondrial Outer Membrane Permeabilization

(2012) Jasmin Schmid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc6 Protein Obstructs Apoptosome Assembly and Consequent Cell Death by Forming Stable Complexes with Activated Apaf-1 Molecules

(2012) Shinichiro Niimi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measuring and Modeling Apoptosis in Single Cells

(2011) Sabrina L. Spencer et al.   CELL

The PIDDosome, DNA-damage-induced apoptosis and beyond

(2011) S Janssens et al.   CELL DEATH AND DIFFERENTIATION

Polypeptide Modulators of Caspase Recruitment Domain (CARD)-CARD-mediated Protein-Protein Interactions

(2011) Yadira Palacios-Rodríguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apaf1 plays a pro-survival role by regulating centrosome morphology and function

(2011) E. Ferraro et al.   JOURNAL OF CELL SCIENCE

The Holo-Apoptosome: Activation of Procaspase-9 and Interactions with Caspase-3

(2011) Shujun Yuan et al.   STRUCTURE

Crystal Structure of Full-Length Apaf-1: How the Death Signal Is Relayed in the Mitochondrial Pathway of Apoptosis

(2011) Thomas Frank Reubold et al.   STRUCTURE

Structure of an Apoptosome-Procaspase-9 CARD Complex

(2010) Shujun Yuan et al.   STRUCTURE

The Apaf-1•procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer

(2009) Srinivas Malladi et al.   EMBO JOURNAL

Human Caspases: Activation, Specificity, and Regulation

(2009) Cristina Pop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Model for the Transition of APAF-1 from Inactive Monomer to Caspase-activating Apoptosome

(2009) Thomas F. Reubold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular signaling dynamics during apoptosis execution in the presence or absence of X-linked-inhibitor-of-apoptosis-protein

(2008) Carla L. O'Connor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of Apoptosome Activation Protects Injured Motor Neurons from Cell Death

(2008) Anish Kumar Kanungo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PHAPI, CAS, and Hsp70 Promote Apoptosome Formation by Preventing Apaf-1 Aggregation and Enhancing Nucleotide Exchange on Apaf-1

(2008) Hyun-Eui Kim et al.   MOLECULAR CELL

Quantitative Analysis of Pathways Controlling Extrinsic Apoptosis in Single Cells

(2008) John G. Albeck et al.   MOLECULAR CELL

The anticancer drug cisplatin induces an intrinsic apoptotic pathway inside the inner ear

(2007) J R García-Berrocal et al.   BRITISH JOURNAL OF PHARMACOLOGY