From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine

Systems Analysis of BCL2 Protein Family Interactions Establishes a Model to Predict Responses to Chemotherapy

(2013) A. U. Lindner et al.   CANCER RESEARCH

Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells

(2013) E Passante et al.   CELL DEATH AND DIFFERENTIATION

Turning Tumors into Vaccines: Co-opting the Innate Immune System

(2013) Jasper G. van den Boorn et al.   IMMUNITY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Systems modelling methodology for the analysis of apoptosis signal transduction and cell death decisions

(2013) Markus Rehm et al.   METHODS

The indirect activation model of mitochondrial outer membrane permeabilisation (MOMP) initiation requires a trade-off between robustness in the absence of and sensitivity in the presence of stress

(2013) Andreas U. Lindner et al.   Molecular BioSystems

A Mathematical Model of Cancer Stem Cell Driven Tumor Initiation: Implications of Niche Size and Loss of Homeostatic Regulatory Mechanisms

(2013) Sara N. Gentry et al.   PLoS One

Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue

(2013) M. J. Gerdes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Where Killers Meet--Permeabilization of the Outer Mitochondrial Membrane during Apoptosis

(2013) T. Bender et al.   Cold Spring Harbor Perspectives in Biology

Mechanisms of Action of Bcl-2 Family Proteins

(2013) A. Shamas-Din et al.   Cold Spring Harbor Perspectives in Biology

Activation of executioner caspases is a predictor of progression-free survival in glioblastoma patients: a systems medicine approach

(2013) Á C Murphy et al.   Cell Death & Disease

Reconsidering the Paradigm of Cancer Immunotherapy by Computationally Aided Real-time Personalization

(2012) Y. Kogan et al.   CANCER RESEARCH

Relative Mitochondrial Priming of Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML

(2012) Thanh-Trang Vo et al.   CELL

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

(2012) Michael J. Lee et al.   CELL

The C-terminal helix of Bcl-xL mediates Bax retrotranslocation from the mitochondria

(2012) F Todt et al.   CELL DEATH AND DIFFERENTIATION

Rsk-mediated phosphorylation and 14-3-3ε binding of Apaf-1 suppresses cytochromec-induced apoptosis

(2012) Jiyeon Kim et al.   EMBO JOURNAL

Systems Analysis of Cancer Cell Heterogeneity in Caspase-dependent Apoptosis Subsequent to Mitochondrial Outer Membrane Permeabilization

(2012) Jasmin Schmid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc6 Protein Obstructs Apoptosome Assembly and Consequent Cell Death by Forming Stable Complexes with Activated Apaf-1 Molecules

(2012) Shinichiro Niimi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model

(2012) Kolja Schleich et al.   MOLECULAR CELL

Defining the mode of tumour growth by clonal analysis

(2012) Gregory Driessens et al.   NATURE

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Central roles of apoptotic proteins in mitochondrial function

(2012) S M Kilbride et al.   ONCOGENE

Exploring the Contextual Sensitivity of Factors that Determine Cell-to-Cell Variability in Receptor-Mediated Apoptosis

(2012) Suzanne Gaudet et al.   PLoS Computational Biology

DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients

(2012) C Allera-Moreau et al.   Oncogenesis

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

(2011) Frank Edlich et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

The Molecular Machinery Regulating Apoptosis Signal Transduction and its Implication in Human Physiology and Pathophysiologies

(2011) C. T. Hellwig et al.   CURRENT MOLECULAR MEDICINE

Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy

(2011) Suzanne Hector et al.   GUT

A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria

(2011) Fabien Llambi et al.   MOLECULAR CELL

Glucose metabolism determines resistance of cancer cells to bioenergetic crisis after cytochrome-c release

(2011) H. J. Huber et al.   Molecular Systems Biology

Bring on the biomarkers

(2011) George Poste   NATURE

Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

(2011) Qian Huang et al.   NATURE MEDICINE

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Phase III and submission failures: 2007–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

(2011) T. N. Chonghaile et al.   SCIENCE

Modeling Evolutionary Dynamics of Epigenetic Mutations in Hierarchically Organized Tumors

(2011) Andrea Sottoriva et al.   PLoS Computational Biology

A Computational Systems Biology Software Platform for Multiscale Modeling and Simulation: Integrating Whole-Body Physiology, Disease Biology, and Molecular Reaction Networks

(2011) Thomas Eissing   Frontiers in Physiology

Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death

(2010) Heinrich J Huber et al.   BMC Systems Biology

Basal Dynamics of p53 Reveal Transcriptionally Attenuated Pulses in Cycling Cells

(2010) Alexander Loewer et al.   CELL

Bcl-2 family proteins and mitochondrial fission/fusion dynamics

(2010) Arnaud Autret et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Apoptotic Cells Activate the "Phoenix Rising" Pathway to Promote Wound Healing and Tissue Regeneration

(2010) F. Li et al.   Science Signaling

Dynamics of outer mitochondrial membrane permeabilization during apoptosis

(2009) M Rehm et al.   CELL DEATH AND DIFFERENTIATION

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation

(2009) H Düssmann et al.   CELL DEATH AND DIFFERENTIATION

The Apaf-1•procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer

(2009) Srinivas Malladi et al.   EMBO JOURNAL

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins

(2009) Delphine Mérino et al.   JOURNAL OF CELL BIOLOGY

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

Membrane promotes tBID interaction with BCLXL

(2009) Ana J García-Sáez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pulsatile Stimulation Determines Timing and Specificity of NF- B-Dependent Transcription

(2009) L. Ashall et al.   SCIENCE

Efficacy of Weekly Docetaxel and Bevacizumab in Mesenchymal Chondrosarcoma: A New Theranostic Method Combining Xenografted Biopsies with a Mathematical Model

(2008) Boris Gorelik et al.   CANCER RESEARCH

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

(2008) Jonathan F. Lovell et al.   CELL

Quantitative Analysis of Pathways Controlling Extrinsic Apoptosis in Single Cells

(2008) John G. Albeck et al.   MOLECULAR CELL

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY