Systems biology of death receptor networks: live and let die

Mathematical modeling of apoptosis

(2013) Kolja Schleich et al.   Cell Communication and Signaling

The chains of death

(2013) Kolja Schleich et al.   CELL CYCLE

Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis

(2013) J Beaudouin et al.   CELL DEATH AND DIFFERENTIATION

Systems analysis of apoptosis protein expression allows the case-specific prediction of cell death responsiveness of melanoma cells

(2013) E Passante et al.   CELL DEATH AND DIFFERENTIATION

Systems modelling methodology for the analysis of apoptosis signal transduction and cell death decisions

(2013) Markus Rehm et al.   METHODS

Fas/CD95-Induced Chemokines Can Serve as “Find-Me” Signals for Apoptotic Cells

(2013) Sean P. Cullen et al.   MOLECULAR CELL

Activation of executioner caspases is a predictor of progression-free survival in glioblastoma patients: a systems medicine approach

(2013) Á C Murphy et al.   Cell Death & Disease

Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP

(2012) Yuan Shi et al.   BIOINFORMATICS

Generation and physiological roles of linear ubiquitin chains

(2012) Henning Walczak et al.   BMC BIOLOGY

Cellular FLICE-like inhibitory proteins (c-FLIPs): Fine-tuners of life and death decisions

(2012) Selcen Öztürk et al.   EXPERIMENTAL CELL RESEARCH

Proteasome Inhibition Can Impair Caspase-8 Activation upon Submaximal Stimulation of Apoptotic Tumor Necrosis Factor-related Apoptosis Inducing Ligand (TRAIL) Signaling

(2012) Maike A. Laussmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL

(2012) Eva Szegezdi et al.   MOLECULAR & CELLULAR PROTEOMICS

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

(2012) Laura S. Dickens et al.   MOLECULAR CELL

Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model

(2012) Kolja Schleich et al.   MOLECULAR CELL

Measuring and Modeling Apoptosis in Single Cells

(2011) Sabrina L. Spencer et al.   CELL

Regulation of CD95/Fas signaling at the DISC

(2011) I N Lavrik et al.   CELL DEATH AND DIFFERENTIATION

Fas death receptor signalling: roles of Bid and XIAP

(2011) T Kaufmann et al.   CELL DEATH AND DIFFERENTIATION

Clinical application of a systems model of apoptosis execution for the prediction of colorectal cancer therapy responses and personalisation of therapy

(2011) Suzanne Hector et al.   GUT

Modeling Reveals That Dynamic Regulation of c-FLIP Levels Determines Cell-to-Cell Distribution of CD95-mediated Apoptosis

(2011) Hannu T. Toivonen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis

(2011) B. B. Aldridge et al.   Molecular Systems Biology

It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival

(2011) Andrew Oberst et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Emerging Role of Linear Ubiquitination in Cell Signaling

(2011) C. H. Emmerich et al.   Science Signaling

Caspase-8 activity has an essential role in CD95/Fas-mediated MAPK activation

(2011) A M M Kober et al.   Cell Death & Disease

Enhancing apoptosis in TRAIL-resistant cancer cells using fundamental response rules

(2011) Vincent Piras et al.   Scientific Reports

Systems biology of apoptosis signaling networks

(2010) Inna N Lavrik   CURRENT OPINION IN BIOTECHNOLOGY

The Caspase-8 Dimerization/Dissociation Balance Is a Highly Potent Regulator of Caspase-8, -3, -6 Signaling

(2010) Maximilian L. Würstle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL

(2010) Nicolai Fricker et al.   JOURNAL OF CELL BIOLOGY

Dynamics within the CD95 death-inducing signaling complex decide life and death of cells

(2010) Leo Neumann et al.   Molecular Systems Biology

The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis

(2010) P. Vandenabeele et al.   Science Signaling

Bistability in Apoptosis by Receptor Clustering

(2010) Kenneth L. Ho et al.   PLoS Computational Biology

Mathematical Modelling of Cell-Fate Decision in Response to Death Receptor Engagement

(2010) Laurence Calzone et al.   PLoS Computational Biology

Dynamics of outer mitochondrial membrane permeabilization during apoptosis

(2009) M Rehm et al.   CELL DEATH AND DIFFERENTIATION

The Many Roles of FAS Receptor Signaling in the Immune System

(2009) Andreas Strasser et al.   IMMUNITY

A New C-Terminal Cleavage Product of Procaspase-8, p30, Defines an Alternative Pathway of Procaspase-8 Activation

(2009) J. C. Hoffmann et al.   MOLECULAR AND CELLULAR BIOLOGY

Understanding apoptosis by systems biology approaches

(2009) Inna N. Lavrik et al.   Molecular BioSystems

XIAP discriminates between type I and type II FAS-induced apoptosis

(2009) Philipp J. Jost et al.   NATURE

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

Death receptor signal transducers: nodes of coordination in immune signaling networks

(2009) Nicholas S Wilson et al.   NATURE IMMUNOLOGY

Mechanism of procaspase-8 activation by c-FLIPL

(2009) J. W. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ON/OFF and Beyond - A Boolean Model of Apoptosis

(2009) Rebekka Schlatter et al.   PLoS Computational Biology

Quantitative Analysis of Pathways Controlling Extrinsic Apoptosis in Single Cells

(2008) John G. Albeck et al.   MOLECULAR CELL

Computational Insights on the Competing Effects of Nitric Oxide in Regulating Apoptosis

(2008) Elife Z. Bagci et al.   PLoS One

Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death

(2008) John G Albeck et al.   PLOS BIOLOGY