STAT3 Protein Up-regulates Gα-interacting Vesicle-associated Protein (GIV)/Girdin Expression, and GIV Enhances STAT3 Activation in a Positive Feedback Loop during Wound Healing and Tumor Invasion/Metastasis

Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling

(2012) M. Garcia-Marcos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human skin transcriptome during superficial cutaneous wound healing

(2012) Kristo Nuutila et al.   WOUND REPAIR AND REGENERATION

HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop

(2011) Zanobia A Syed et al.   BMC CANCER

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

(2011) Victoria Sanz-Moreno et al.   CANCER CELL

Clinical Implications for Girdin Protein Expression in Breast Cancer

(2011) Yun Ling et al.   CANCER INVESTIGATION

The Actin-Binding Protein Girdin and Its Akt-Mediated Phosphorylation Regulate Neointima Formation After Vascular Injury

(2011) Hiroshi Miyake et al.   CIRCULATION RESEARCH

STAT3 Expression, Molecular Features, Inflammation Patterns, and Prognosis in a Database of 724 Colorectal Cancers

(2011) Teppei Morikawa et al.   CLINICAL CANCER RESEARCH

Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors

(2011) Arun K Mankan et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Signal transducer and activator of transcription 3 (STAT3): a promising target for anticancer therapy

(2011) Daniela Masciocchi et al.   Future Medicinal Chemistry

Tumor Promotion via Injury- and Death-Induced Inflammation

(2011) Ali Kuraishy et al.   IMMUNITY

Src Homology Domain 2-containing Protein-tyrosine Phosphatase-1 (SHP-1) Binds and Dephosphorylates Gα-interacting, Vesicle-associated Protein (GIV)/Girdin and Attenuates the GIV-Phosphatidylinositol 3-Kinase (PI3K)-Akt Signaling Pathway

(2011) Yash Mittal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Girdin protein: a new potential distant metastasis predictor of breast cancer

(2011) Caigang Liu et al.   MEDICAL ONCOLOGY

A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals

(2011) Mikel Garcia-Marcos et al.   MOLECULAR BIOLOGY OF THE CELL

DISC1-binding proteins in neural development, signalling and schizophrenia

(2011) Nicholas J. Bradshaw et al.   NEUROPHARMACOLOGY

Girdin maintains the stemness of glioblastoma stem cells

(2011) A Natsume et al.   ONCOGENE

Tyrosine Phosphorylation of the G -Interacting Protein GIV Promotes Activation of Phosphoinositide 3-Kinase During Cell Migration

(2011) C. Lin et al.   Science Signaling

GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression

(2011) Pradipta Ghosh et al.   Cell Adhesion & Migration

Transcription Factor Stat3 Stimulates Metastatic Behavior of Human Prostate Cancer Cells in Vivo, whereas Stat5b Has a Preferential Role in the Promotion of Prostate Cancer Cell Viability and Tumor Growth

(2010) Lei Gu et al.   AMERICAN JOURNAL OF PATHOLOGY

Signal transducer and activator of transcription 3 inhibitors: a patent review

(2010) Brent DG Page et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer

(2010) Mikel Garcia-Marcos et al.   FASEB JOURNAL

dGirdin a new player of Akt /PKB signaling in Drosophila Melanogaster

(2010) Masamitsu Yamaguchi   Frontiers in Bioscience-Landmark

Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells

(2010) Christian Senft et al.   JOURNAL OF NEURO-ONCOLOGY

A Gαi–GIV Molecular Complex Binds Epidermal Growth Factor Receptor and Determines Whether Cells Migrate or Proliferate

(2010) Pradipta Ghosh et al.   MOLECULAR BIOLOGY OF THE CELL

A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells

(2010) Li Lin et al.   Molecular Cancer

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

(2010) Heehyoung Lee et al.   NATURE MEDICINE

The RhoU/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways

(2009) Davide Schiavone et al.   BIOCHEMICAL JOURNAL

STAT3 as a Central Regulator of Tumor Metastases

(2009) Eswaran Devarajan et al.   CURRENT MOLECULAR MEDICINE

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

A novel Drosophila Girdin-like protein is involved in Akt pathway control of cell size

(2009) Aekkachai Puseenam et al.   EXPERIMENTAL CELL RESEARCH

Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors

(2009) Hyokjoon Kwon et al.   IMMUNITY

Reciprocal Effects of STAT5 and STAT3 in Breast Cancer

(2009) S. R. Walker et al.   MOLECULAR CANCER RESEARCH

Roles of Disrupted-In-Schizophrenia 1-Interacting Protein Girdin in Postnatal Development of the Dentate Gyrus

(2009) Atsushi Enomoto et al.   NEURON

GIV is a nonreceptor GEF for G i with a unique motif that regulates Akt signaling

(2009) M. Garcia-Marcos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Actin-Binding Protein Girdin Regulates the Motility of Breast Cancer Cells

(2008) P. Jiang et al.   CANCER RESEARCH

Roles of unphosphorylated STATs in signaling

(2008) Jinbo Yang et al.   CELL RESEARCH

Activation of Gαi3 triggers cell migration via regulation of GIV

(2008) Pradipta Ghosh et al.   JOURNAL OF CELL BIOLOGY

Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin

(2008) Tomoya Kitamura et al.   NATURE CELL BIOLOGY

Impact of Stat3 activation upon skin biology: A dichotomy of its role between homeostasis and diseases

(2007) Shigetoshi Sano et al.   JOURNAL OF DERMATOLOGICAL SCIENCE