Functional characterization of the guanine nucleotide exchange factor (GEF) motif of GIV protein reveals a threshold effect in signaling

A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals

(2011) Mikel Garcia-Marcos et al.   MOLECULAR BIOLOGY OF THE CELL

Tyrosine Phosphorylation of the G -Interacting Protein GIV Promotes Activation of Phosphoinositide 3-Kinase During Cell Migration

(2011) C. Lin et al.   Science Signaling

GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression

(2011) Pradipta Ghosh et al.   Cell Adhesion & Migration

Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer

(2010) Mikel Garcia-Marcos et al.   FASEB JOURNAL

A Structural Determinant That Renders GαiSensitive to Activation by GIV/Girdin Is Required to Promote Cell Migration

(2010) Mikel Garcia-Marcos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Gαi–GIV Molecular Complex Binds Epidermal Growth Factor Receptor and Determines Whether Cells Migrate or Proliferate

(2010) Pradipta Ghosh et al.   MOLECULAR BIOLOGY OF THE CELL

DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212

(2009) Ju Young Kim et al.   NEURON

Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues

(2009) A. Lipshtat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GIV is a nonreceptor GEF for G i with a unique motif that regulates Akt signaling

(2009) M. Garcia-Marcos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

(2008) Arun Radhakrishnan et al.   Cell Metabolism

Coactivation of G Protein Signaling by Cell-Surface Receptors and an Intracellular Exchange Factor

(2008) Michael J. Lee et al.   CURRENT BIOLOGY

Activation of Gαi3 triggers cell migration via regulation of GIV

(2008) Pradipta Ghosh et al.   JOURNAL OF CELL BIOLOGY

Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin

(2008) Tomoya Kitamura et al.   NATURE CELL BIOLOGY