Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors

Inhibiting aberrant Stat3 function with molecular therapeutics

(2010) Sina Haftchenary et al.   ANTI-CANCER DRUGS

Human Th17 cells can be induced through head and neck cancer and have a functional impact on HNSCC development

(2010) R Kesselring et al.   BRITISH JOURNAL OF CANCER

Immunologic Consequences of Signal Transducers and Activators of Transcription 3 Activation in Human Squamous Cell Carcinoma

(2010) E. Albesiano et al.   CANCER RESEARCH

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Prognostic significance of p-STAT3 in patients with bulky cervical carcinoma undergoing neoadjuvant chemotherapy

(2010) Chel Hun Choi et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival

(2010) A Scuto et al.   LEUKEMIA

Peering into the aftermath: JAKi rips STAT3 in cancer

(2010) Florian R Greten et al.   NATURE MEDICINE

Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?

(2009) Jayaraj Ravindran et al.   AAPS Journal

Signal Transducer and Activator of Transcription-3, Inflammation, and Cancer

(2009) Bharat B. Aggarwal et al.   Annals of the New York Academy of Sciences

The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

(2009) Michael Hedvat et al.   CANCER CELL

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

IKK/NF-κB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis

(2009) Julia Bollrath et al.   EMBO REPORTS

Serum interleukin-6 levels in colorectal cancer patients—a summary of published results

(2009) Heike Knüpfer et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study

(2008) N Nishimoto et al.   ANNALS OF THE RHEUMATIC DISEASES

Th17 and cancer: friends or foes?

(2008) V. Bronte   BLOOD

Myeloproliferative disorders

(2008) R. L. Levine et al.   BLOOD

STAT3 as a target for inducing apoptosis in solid and hematological tumors

(2008) Khandaker Al Zaid Siddiquee et al.   CELL RESEARCH

Molecular Approaches towards the Inhibition of the Signal Transducer and Activator of Transcription 3 (Stat3) Protein

(2008) Steven Fletcher et al.   ChemMedChem

Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function

(2008) George Z. Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency of Th17 cells in hyper IgE syndrome due to mutations inSTAT3

(2008) Cindy S. Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells

(2008) Jinhai Gu et al.   JOURNAL OF NEURO-ONCOLOGY

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

(2008) Sandra Rebouissou et al.   NATURE

Tumor Angiogenesis

(2008) Robert S. Kerbel   NEW ENGLAND JOURNAL OF MEDICINE

The function of Stat3 in tumor cells and their microenvironment

(2008) Bernd Groner et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Role for JAK2 Mutations in Myeloproliferative Diseases

(2007) Kelly J. Morgan et al.   Annual Review of Medicine

STAT3: A critical transcription activator in angiogenesis

(2007) Zhong Chen et al.   MEDICINAL RESEARCH REVIEWS