Epigenetic differences in human cartilage between mild and severe OA

Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients

(2013) Juan Fernández-Tajes et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG Sites

(2013) Ko Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

rAAV-mediated overexpression of TGF-β stably restructures human osteoarthritic articular cartilage in situ

(2013) Jagadeesh K Venkatesan et al.   Journal of Translational Medicine

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

To Wnt or not to Wnt: the bone and joint health dilemma

(2013) Rik J. Lories et al.   Nature Reviews Rheumatology

Regulation of bone and cartilage development by network between BMP signalling and transcription factors

(2012) R. Nishimura et al.   JOURNAL OF BIOCHEMISTRY

TGF-β Drives DNA Demethylation

(2012) David Wotton   MOLECULAR CELL

Age-dependent alteration of TGF-β signalling in osteoarthritis

(2011) Peter M. van der Kraan et al.   CELL AND TISSUE RESEARCH

Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor β-activated kinase 1/activating transcription factor 2 signaling: A potential clinical implication for osteoarthritis

(2010) Tian-Fang Li et al.   ARTHRITIS AND RHEUMATISM

To Seek Shelter from the Wnt in Osteoarthritis? Wnt-Signaling as a Target for Osteoarthritis Therapy

(2010) Arjen B. Blom et al.   CURRENT DRUG TARGETS

Bone Morphogenetic Proteins and articular cartilage

(2010) P.M. van der Kraan et al.   OSTEOARTHRITIS AND CARTILAGE

Differential upregulation of the three transforming growth factor beta isoforms in human osteoarthritic cartilage

(2008) M Pombo-Suarez et al.   ANNALS OF THE RHEUMATIC DISEASES

The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: Findings in murine models and in human disease

(2008) Shingo Sato et al.   ARTHRITIS AND RHEUMATISM

PCR-Based Analysis of Differentially Methylated Regions of GNAS Enables Convenient Diagnostic Testing of Pseudohypoparathyroidism Type Ib

(2008) A. Weinhaeusel et al.   CLINICAL CHEMISTRY

Interleukin-1 and Transforming Growth Factor-ß 1 as Crucial Factors in Osteoarthritic Cartilage Metabolism

(2008) Jean-Pierre Pujol et al.   CONNECTIVE TISSUE RESEARCH

Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage

(2008) R.F. Loeser et al.   OSTEOARTHRITIS AND CARTILAGE