The way Wnt works: Components and mechanism

Tiki1 Is Required for Head Formation via Wnt Cleavage-Oxidation and Inactivation

(2012) Xinjun Zhang et al.   CELL

Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

(2012) Vivian S.W. Li et al.   CELL

Cell cycle control of Wnt/β-catenin signalling by conductin/axin2 through CDC20

(2012) Michel V Hadjihannas et al.   EMBO REPORTS

Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling

(2012) H. Sakane et al.   JOURNAL OF CELL SCIENCE

The E3 Ubiquitin Ligase ITCH Negatively Regulates Canonical Wnt Signaling by Targeting Dishevelled Protein

(2012) W. Wei et al.   MOLECULAR AND CELLULAR BIOLOGY

XIAP Monoubiquitylates Groucho/TLE to Promote Canonical Wnt Signaling

(2012) Alison J. Hanson et al.   MOLECULAR CELL

Recurrent R-spondin fusions in colon cancer

(2012) Somasekar Seshagiri et al.   NATURE

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

Wnt Signalling Pathway Parameters for Mammalian Cells

(2012) Chin Wee Tan et al.   PLoS One

Wnt/ -catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled

(2012) D. V. F. Tauriello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Kinetic Responses of  -Catenin Specify the Sites of Wnt Control

(2012) A. R. Hernandez et al.   SCIENCE

Ras Stabilization Through Aberrant Activation of Wnt/ -Catenin Signaling Promotes Intestinal Tumorigenesis

(2012) W.-J. Jeong et al.   Science Signaling

Wnt Signaling in Mammalian Development: Lessons from Mouse Genetics

(2012) J. Wang et al.   Cold Spring Harbor Perspectives in Biology

Porcupine-mediated lipidation is required for Wnt recognition by Wls

(2011) Patrick Herr et al.   DEVELOPMENTAL BIOLOGY

Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6

(2011) Victoria E. Ahn et al.   DEVELOPMENTAL CELL

Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling

(2011) Shuo Chen et al.   DEVELOPMENTAL CELL

Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2to LRP6 phosphorylation

(2011) Kristina Tanneberger et al.   EMBO JOURNAL

p24 proteins are required for secretion of Wnt ligands

(2011) Tina Buechling et al.   EMBO REPORTS

A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion

(2011) Fillip Port et al.   EMBO REPORTS

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

(2011) Andrei Glinka et al.   EMBO REPORTS

Phosphorylation of TCF Proteins by Homeodomain-interacting Protein Kinase 2

(2011) Hiroki Hikasa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Armadillo Repeat Sequences Facilitate β-Catenin Nuclear Transport in Live Cells via Direct Binding to Nucleoporins Nup62, Nup153, and RanBP2/Nup358

(2011) Manisha Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ubiquitin-Specific Protease USP34 Regulates Axin Stability and Wnt/ -Catenin Signaling

(2011) T. T. H. Lui et al.   MOLECULAR AND CELLULAR BIOLOGY

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

(2011) Yue Zhang et al.   NATURE CELL BIOLOGY

Opposing effects of Tcf3 and Tcf1 control Wnt stimulation of embryonic stem cell self-renewal

(2011) Fei Yi et al.   NATURE CELL BIOLOGY

Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

(2011) Zhihong Cheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ubiquitin Ligase RNF146 Regulates Tankyrase and Axin to Promote Wnt Signaling

(2011) Marinella G. Callow et al.   PLoS One

Quiescent gastric stem cells maintain the adult Drosophila stomach

(2011) M. Strand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WNTing embryonic stem cells

(2011) Jason Wray et al.   TRENDS IN CELL BIOLOGY

The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled

(2011) C. Mendoza-Topaz et al.   Open Biology

Wnt/β-Catenin Pathway Activation Is Enriched in Basal-Like Breast Cancers and Predicts Poor Outcome

(2010) Andrey I. Khramtsov et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification

(2010) Hiroki Hikasa et al.   DEVELOPMENTAL CELL

Induction of pluripotency by defined factors

(2010) Keisuke Okita et al.   EXPERIMENTAL CELL RESEARCH

Myristoylated Naked2 Antagonizes Wnt-β-Catenin Activity by Degrading Dishevelled-1 at the Plasma Membrane

(2010) Tianhui Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Protein Stability of Axin, a Negative Regulator of Wnt Signaling, Is Regulated by Smad Ubiquitination Regulatory Factor 2 (Smurf2)

(2010) Sewoon Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6

(2010) Eric Bourhis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation

(2010) Felipe C Geyer et al.   MODERN PATHOLOGY

The EDD E3 ubiquitin ligase ubiquitinates and up-regulates β-catenin

(2010) Avital Hay-Koren et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of the Tumor Suppressor CYLD Enhances Wnt/β-Catenin Signaling through K63-Linked Ubiquitination of Dvl

(2010) Daniele V.F. Tauriello et al.   MOLECULAR CELL

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

(2010) Curtis A Thorne et al.   Nature Chemical Biology

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

(2010) C.-C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

(2010) W. R. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

(2010) H. J. Snippert et al.   SCIENCE

G   Activates GSK3 to Promote LRP6-Mediated  -Catenin Transcriptional Activity

(2010) K. K. Jernigan et al.   Science Signaling

Wnt Trafficking: New Insights into Wnt Maturation, Secretion and Spreading

(2010) Fillip Port et al.   TRAFFIC

Functional Significance of Wnt Inhibitory Factor-1 Gene in Kidney Cancer

(2009) K. Kawakami et al.   CANCER RESEARCH

Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless

(2009) Ceren Korkut et al.   CELL

WNT/TCF Signaling through LEF1 and HOXB9 Mediates Lung Adenocarcinoma Metastasis

(2009) Don X. Nguyen et al.   CELL

Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis

(2009) Shih-Lei Lai et al.   CELL RESEARCH

Wnt Antagonist Gene DKK2 Is Epigenetically Silenced and Inhibits Renal Cancer Progression through Apoptotic and Cell Cycle Pathways

(2009) H. Hirata et al.   CLINICAL CANCER RESEARCH

Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation

(2009) W.-C. Lee et al.   DEVELOPMENT

A New Look at TCF and β-Catenin through the Lens of a Divergent C. elegans Wnt Pathway

(2009) Bryan T. Phillips et al.   DEVELOPMENTAL CELL

Dual Role of Wingless Signaling in Stem-like Hematopoietic Precursor Maintenance in Drosophila

(2009) Sergey A. Sinenko et al.   DEVELOPMENTAL CELL

Cell Cycle Control of Wnt Receptor Activation

(2009) Gary Davidson et al.   DEVELOPMENTAL CELL

The Core Protein of Glypican Dally-Like Determines Its Biphasic Activity in Wingless Morphogen Signaling

(2009) Dong Yan et al.   DEVELOPMENTAL CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Centrosomal localization of Diversin and its relevance to Wnt signaling

(2009) K. Itoh et al.   JOURNAL OF CELL SCIENCE

The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway

(2009) Bin Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The COP9 Signalosome Mediates β-Catenin Degradation by Deneddylation and Blocks Adenomatous Polyposis coli Destruction via USP15

(2009) Xiaohua Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling

(2009) Lea Goentoro et al.   MOLECULAR CELL

The Incoherent Feedforward Loop Can Provide Fold-Change Detection in Gene Regulation

(2009) Lea Goentoro et al.   MOLECULAR CELL

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

β-Catenin hits chromatin: regulation of Wnt target gene activation

(2009) Christian Mosimann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Basis of Colorectal Cancer

(2009) Sanford D. Markowitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma

(2009) G Akiri et al.   ONCOGENE

The Internally Truncated LRP5 Receptor Presents a Therapeutic Target in Breast Cancer

(2009) Peyman Björklund et al.   PLoS One

Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6

(2009) Geng Wu et al.   PLoS One

Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming

(2009) Wenlin Li et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Wnt Signaling from Development to Disease: Insights from Model Systems

(2009) K. M. Cadigan et al.   Cold Spring Harbor Perspectives in Biology

Planar Cell Polarity Signaling: From Fly Development to Human Disease

(2008) Matias Simons et al.   Annual Review of Genetics

Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer

(2008) H Suzuki et al.   BRITISH JOURNAL OF CANCER

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

(2008) Ximei Wu et al.   CELL

Wnt signaling and stem cell control

(2008) Roel Nusse   CELL RESEARCH

Wnt Signaling Promotes Reprogramming of Somatic Cells to Pluripotency

(2008) Alexander Marson et al.   Cell Stem Cell

Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo

(2008) Wynne Peterson-Nedry et al.   DEVELOPMENTAL BIOLOGY

Cellular Trafficking of the Glypican Dally-like Is Required for Full-Strength Hedgehog Signaling and Wingless Transcytosis

(2008) Armel Gallet et al.   DEVELOPMENTAL CELL

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

(2008) Min Jung Kim et al.   FASEB JOURNAL

Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains

(2008) H. Tran et al.   GENES & DEVELOPMENT

Wilms tumor genetics: Mutations inWT1,WTX, andCTNNB1 account for only about one-third of tumors

(2008) E. Cristy Ruteshouser et al.   GENES CHROMOSOMES & CANCER

Wnt Signal Amplification via Activity, Cooperativity, and Regulation of Multiple Intracellular PPPSP Motifs in the Wnt Co-receptor LRP6

(2008) Bryan T. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease

(2008) P. Bovolenta et al.   JOURNAL OF CELL SCIENCE

Plasma membrane recruitment of dephosphorylated  -catenin upon activation of the Wnt pathway

(2008) J. Hendriksen et al.   JOURNAL OF CELL SCIENCE

Cell-Type-Specific Function of BCL9 Involves a Transcriptional Activation Domain That Synergizes with  -Catenin

(2008) C. Sustmann et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-Wide Pattern of TCF7L2/TCF4 Chromatin Occupancy in Colorectal Cancer Cells

(2008) P. Hatzis et al.   MOLECULAR AND CELLULAR BIOLOGY

Decoding of Methylated Histone H3 Tail by the Pygo-BCL9 Wnt Signaling Complex

(2008) Marc Fiedler et al.   MOLECULAR CELL

APC Is Essential for Targeting Phosphorylated β-Catenin to the SCFβ-TrCP Ubiquitin Ligase

(2008) YunYun Su et al.   MOLECULAR CELL

Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells

(2008) Guonan Lin et al.   NATURE

The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling

(2008) Shigeo Takashima et al.   NATURE

Wingless secretion promotes and requires retromer-dependent cycling of Wntless

(2008) Fillip Port et al.   NATURE CELL BIOLOGY

Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex

(2008) Xavier Franch-Marro et al.   NATURE CELL BIOLOGY

Recruitment of adenomatous polyposis coli and β-catenin to axin-puncta

(2008) M C Faux et al.   ONCOGENE

Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling

(2008) Shunfu Piao et al.   PLoS One

LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of  -catenin

(2008) C. S. Cselenyi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt3a-Mediated Formation of Phosphatidylinositol 4,5-Bisphosphate Regulates LRP6 Phosphorylation

(2008) W. Pan et al.   SCIENCE

A Wnt-fall for Gene Regulation: Repression

(2008) N. P. Hoverter et al.   Science Signaling

Alternative Wnt Signaling Is Initiated by Distinct Receptors

(2008) R. van Amerongen et al.   Science Signaling

Tcf3 Functions as a Steady-State Limiter of Transcriptional Programs of Mouse Embryonic Stem Cell Self-Renewal

(2008) Fei Yi et al.   STEM CELLS

Crystal Structure of a Full-Length β-Catenin

(2008) Yi Xing et al.   STRUCTURE

Wnt signaling pathway and lung disease

(2008) Michelle Van Scoyk et al.   Translational Research

Glypicans

(2008) Jorge Filmus et al.   GENOME BIOLOGY

Wnt Signaling Requires Retromer-Dependent Recycling of MIG-14/Wntless in Wnt-Producing Cells

(2007) Pei-Tzu Yang et al.   DEVELOPMENTAL CELL