Terpenoid synthase structures: a so far incomplete view of complex catalysis

Insights into Diterpene Cyclization from Structure of Bifunctional Abietadiene Synthase fromAbies grandis

(2012) Ke Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Isotopically Sensitive Branching on Product Distribution for Pentalenene Synthase: Support for a Mechanism Predicted by Quantum Chemistry

(2012) Liansuo Zu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals

(2011) Dana Morrone et al.   BIOCHEMICAL JOURNAL

Electrostatic effects on (di)terpene synthase product outcome

(2011) Ke Zhou et al.   CHEMICAL COMMUNICATIONS

The Primary Diterpene Synthase Products ofPicea abiesLevopimaradiene/Abietadiene Synthase (PaLAS) Are Epimers of a Thermally Unstable Diterpenol

(2011) Christopher I. Keeling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical Constraints on Sesquiterpene Diversity Arising from Cyclization of the Eudesm-5-yl Carbocation

(2011) B. Andes Hess et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sesquarterpenes (C35Terpenes) Biosynthesized via the Cyclization of a Linear C35Isoprenoid by a Tetraprenyl-β-curcumene Synthase and a Tetraprenyl-β-curcumene Cyclase: Identification of a New Terpene Cyclase

(2011) Tsutomu Sato et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis via carbocations: Theoretical studies on terpene formation

(2011) Dean J. Tantillo   NATURAL PRODUCT REPORTS

Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase

(2011) Mustafa Köksal et al.   Nature Chemical Biology

Divergent evolution of oxidosqualene cyclases in plants

(2011) Zheyong Xue et al.   NEW PHYTOLOGIST

Domain loss has independently occurred multiple times in plant terpene synthase evolution

(2011) Matthew L. Hillwig et al.   PLANT JOURNAL

The family of terpene synthases in plants: a mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom

(2011) Feng Chen et al.   PLANT JOURNAL

Structure and Mechanism of an Arabidopsis Medium/Long-Chain-Length Prenyl Pyrophosphate Synthase

(2011) F.-L. Hsieh et al.   PLANT PHYSIOLOGY

Structure of a Three-Domain Sesquiterpene Synthase: A Prospective Target for Advanced Biofuels Production

(2011) Ryan P. McAndrew et al.   STRUCTURE

Structural Elucidation of Cisoid and Transoid Cyclization Pathways of a Sesquiterpene Synthase Using 2-Fluorofarnesyl Diphosphates

(2010) Joseph P. Noel et al.   ACS Chemical Biology

Structure of Epi-Isozizaene Synthase fromStreptomyces coelicolorA3(2), a Platform for New Terpenoid Cyclization Templates,

(2010) Julie A. Aaron et al.   BIOCHEMISTRY

Crystal Structure of Heterodimeric Hexaprenyl Diphosphate Synthase fromMicrococcus luteusB-P 26 Reveals That the Small Subunit Is Directly Involved in the Product Chain Length Regulation

(2010) Daisuke Sasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Single Residue Switch for Mg2+-dependent Inhibition Characterizes Plant Class II Diterpene Cyclases from Primary and Secondary Metabolism

(2010) Francis M. Mann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Mechanism of the Magnesium-Independent Aromatic Prenyltransferase CloQ from the Clorobiocin Biosynthetic Pathway

(2010) Ute Metzger et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of Isoprene Synthase Illuminates the Chemical Mechanism of Teragram Atmospheric Carbon Emission

(2010) Mustafa Köksal et al.   JOURNAL OF MOLECULAR BIOLOGY

Challenges Posed to Bornyl Diphosphate Synthase: Diverging Reaction Mechanisms in Monoterpenes

(2010) Michal Weitman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two rings in them all: The labdane-related diterpenoids

(2010) Reuben J. Peters   NATURAL PRODUCT REPORTS

Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis

(2010) Mustafa Köksal et al.   NATURE

Quantum chemical dissection of the classic terpinyl/pinyl/bornyl/camphyl cation conundrum—the role of pyrophosphate in manipulating pathways to monoterpenes

(2010) Young J. Hong et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Structure of a Heterotetrameric Geranyl Pyrophosphate Synthase from Mint (Mentha piperita) Reveals Intersubunit Regulation

(2010) T.-H. Chang et al.   PLANT CELL

Identification and Functional Characterization of Monofunctional ent-Copalyl Diphosphate and ent-Kaurene Synthases in White Spruce Reveal Different Patterns for Diterpene Synthase Evolution for Primary and Secondary Metabolism in Gymnosperms

(2010) C. I. Keeling et al.   PLANT PHYSIOLOGY

Diterpene cyclases and the nature of the isoprene fold

(2010) Rong Cao et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Crystal Structure of (+)-δ-Cadinene Synthase fromGossypium arboreumand Evolutionary Divergence of Metal Binding Motifs for Catalysis

(2009) Heather A. Gennadios et al.   BIOCHEMISTRY

Reaction Kinetics, Catalytic Mechanisms, Conformational Changes, and Inhibitor Design for Prenyltransferases

(2009) Po-Huang Liang   BIOCHEMISTRY

Gibberellin biosynthesis in bacteria: Separateent-copalyl diphosphate andent-kaurene synthases inBradyrhizobium japonicum

(2009) Dana Morrone et al.   FEBS LETTERS

Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants

(2009) Jörg Degenhardt et al.   PHYTOCHEMISTRY

A Novel Pathway for Sesquiterpene Biosynthesis from Z,Z-Farnesyl Pyrophosphate in the Wild Tomato Solanum habrochaites

(2009) C. Sallaud et al.   PLANT CELL

The structure of dimethylallyl tryptophan synthase reveals a common architecture of aromatic prenyltransferases in fungi and bacteria

(2009) U. Metzger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monoterpenes in the glandular trichomes of tomato are synthesized from a neryl diphosphate precursor rather than geranyl diphosphate

(2009) A. L. Schilmiller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Product chain-length determination mechanism of Z , E -farnesyl diphosphate synthase

(2008) Motoyoshi Noike et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Unearthing the roots of the terpenome

(2008) David W Christianson   CURRENT OPINION IN CHEMICAL BIOLOGY

X-ray Crystallographic Studies of Substrate Binding to Aristolochene Synthase Suggest a Metal Ion Binding Sequence for Catalysis

(2008) Ekaterina Y. Shishova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structural Basis of Chain Length Control in Rv1086

(2008) Wenjian Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Increasing Complexity of a Diterpene Synthase Reaction with a Single Residue Switch

(2008) Dana Morrone et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Common Mechanism for Branching, Cyclopropanation, and Cyclobutanation Reactions in the Isoprenoid Biosynthetic Pathway

(2008) Hirekodathakallu V. Thulasiram et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases

(2008) Paul E O'Maille et al.   Nature Chemical Biology

Functional plasticity of paralogous diterpene synthases involved in conifer defense

(2008) C. I. Keeling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: Probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233–Mg2+B motif

(2007) L. Sangeetha Vedula et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS