Post-translational protein modifications in malaria parasites

Heterochromatin Protein 1 Secures Survival and Transmission of Malaria Parasites

(2014) Nicolas M.B. Brancucci et al.   Cell Host & Microbe

Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation

(2014) David S. Guttery et al.   Cell Host & Microbe

A Plasmodium falciparum Histone Deacetylase Regulates Antigenic Variation and Gametocyte Conversion

(2014) Bradley I. Coleman et al.   Cell Host & Microbe

From the Genome to the Phenome: Tools to Understand the Basic Biology ofPlasmodium falciparum

(2014) Wesley A. J. Webster et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Confident and sensitive phosphoproteomics using combinations of collision induced dissociation and electron transfer dissociation

(2014) Mark O. Collins et al.   Journal of Proteomics

A transcriptional switch underlies commitment to sexual development in malaria parasites

(2014) Björn F. C. Kafsack et al.   NATURE

Persistence and activation of malaria hypnozoites in long-term primary hepatocyte cultures

(2014) Laurent Dembélé et al.   NATURE MEDICINE

Phosphoinositide Metabolism Links cGMP-Dependent Protein Kinase G to Essential Ca2+ Signals at Key Decision Points in the Life Cycle of Malaria Parasites

(2014) Mathieu Brochet et al.   PLOS BIOLOGY

Protein S-nitrosylation in Plasmodium falciparum

(2013) Lihui Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)

(2013) Timothy M. Chapman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Toxoplasma Protein ARO Mediates the Apical Positioning of Rhoptry Organelles, a Prerequisite for Host Cell Invasion

(2013) Christina Mueller et al.   Cell Host & Microbe

Silence, activate, poise and switch! Mechanisms of antigenic variation inPlasmodium falciparum

(2013) Julien Guizetti et al.   CELLULAR MICROBIOLOGY

Covalent lipid modifications of proteins

(2013) Marilyn D. Resh   CURRENT BIOLOGY

What does S-palmitoylation do to membrane proteins?

(2013) Sanja Blaskovic et al.   FEBS Journal

Characterization of a Serine Hydrolase Targeted by Acyl-protein Thioesterase Inhibitors inToxoplasma gondii

(2013) Louise E. Kemp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global Analysis of Protein Expression and Phosphorylation of Three Stages of Plasmodium falciparum Intraerythrocytic Development

(2013) Brittany N. Pease et al.   JOURNAL OF PROTEOME RESEARCH

Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions duringPlasmodium falciparumintraerythrocytic development

(2013) Jun Miao et al.   MOLECULAR MICROBIOLOGY

PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum

(2013) Lubin Jiang et al.   NATURE

Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion

(2013) Matthew A Child et al.   Nature Chemical Biology

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach

(2013) Megan H. Wright et al.   Nature Chemistry

Comprehensive Histone Phosphorylation Analysis and Identification of Pf14-3-3 Protein as a Histone H3 Phosphorylation Reader in Malaria Parasites

(2013) Eeshita G. Dastidar et al.   PLoS One

Global Analysis of Apicomplexan Protein S-Acyl Transferases Reveals an Enzyme Essential for Invasion

(2013) Karine Frénal et al.   TRAFFIC

Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum

(2013) Liliana Mancio-Silva et al.   Nature Communications

Malaria Parasite cGMP-dependent Protein Kinase Regulates Blood Stage Merozoite Secretory Organelle Discharge and Egress

(2013) Christine R. Collins et al.   PLoS Pathogens

Analysis of Protein Palmitoylation Reveals a Pervasive Role in Plasmodium Development and Pathogenesis

(2012) Matthew L. Jones et al.   Cell Host & Microbe

A Plasmodium Calcium-Dependent Protein Kinase Controls Zygote Development and Transmission by Translationally Activating Repressed mRNAs

(2012) Sarah Sebastian et al.   Cell Host & Microbe

PfSET10, a Plasmodium falciparum Methyltransferase, Maintains the Active var Gene in a Poised State during Parasite Division

(2012) Jennifer C. Volz et al.   Cell Host & Microbe

Isoprenoid Biosynthesis Inhibition Disrupts Rab5 Localization and Food Vacuolar Integrity in Plasmodium falciparum

(2012) Ruth Howe et al.   EUKARYOTIC CELL

Translational Control in Plasmodium and Toxoplasma Parasites

(2012) Min Zhang et al.   EUKARYOTIC CELL

Plasmodiumkinases as targets for new-generation antimalarials

(2012) Isabelle S Lucet et al.   Future Medicinal Chemistry

The cellular and molecular basis for malaria parasite invasion of the human red blood cell

(2012) Alan F. Cowman et al.   JOURNAL OF CELL BIOLOGY

Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivaxN-Myristoyltransferase

(2012) Mark D. Rackham et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Plasmodium vivaxN-Myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of their Binding Mode

(2012) Victor Goncalves et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Plasmodium falciparum Schizont Phosphoproteome Reveals Extensive Phosphatidylinositol and cAMP-Protein Kinase A Signaling

(2012) Edwin Lasonder et al.   JOURNAL OF PROTEOME RESEARCH

Global malaria mortality between 1980 and 2010: a systematic analysis

(2012) Christopher JL Murray et al.   LANCET

Insights into the Plasmodium falciparum schizont phospho-proteome

(2012) Edwin Lasonder et al.   MICROBES AND INFECTION

The kinomes of apicomplexan parasites

(2012) Diego Miranda-Saavedra et al.   MICROBES AND INFECTION

An evolutionary perspective on the kinome of malaria parasites

(2012) E. Talevich et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum

(2012) N. A. Malmquist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PK4, a eukaryotic initiation factor 2 (eIF2 ) kinase, is essential for the development of the erythrocytic cycle of Plasmodium

(2012) M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissection of Minimal Sequence Requirements for Rhoptry Membrane Targeting in the Malaria Parasite

(2012) Ana Cabrera et al.   TRAFFIC

Targeting protein lipidation in disease

(2012) Marilyn D. Resh   TRENDS IN MOLECULAR MEDICINE

Getting stuck in: protein palmitoylation in Plasmodium

(2012) Matthew L. Jones et al.   TRENDS IN PARASITOLOGY

Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs

(2012) Andrew S. Bell et al.   PLoS Neglected Tropical Diseases

Protein S-Glutathionylation in Malaria Parasites

(2011) Sebastian Kehr et al.   ANTIOXIDANTS & REDOX SIGNALING

Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa

(2011) Eric Talevich et al.   BMC EVOLUTIONARY BIOLOGY

SnapShot: Histone Readers

(2011) Tatiana G. Kutateladze   CELL

The Phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii Reveal Unusual Adaptations Within and Beyond the Parasites' Boundaries

(2011) Moritz Treeck et al.   Cell Host & Microbe

Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes

(2011) Audrey Sicard et al.   CELLULAR MICROBIOLOGY

The State of the Art in Anti-Malarial Drug Discovery and Development

(2011) Jeremy N. Burrows et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Unraveling the Ubiquitome of the Human Malaria Parasite

(2011) Nadia Ponts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overlooked post-translational modifications of proteins in Plasmodium falciparum: N- and O-glycosylation - A Review

(2011) Cristiana S de Macedo et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Global profiling of dynamic protein palmitoylation

(2011) Brent R Martin et al.   NATURE METHODS

Toxoplasma gondiisequesters centromeres to a specific nuclear region throughout the cell cycle

(2011) Carrie F. Brooks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

(2011) Lev Solyakov et al.   Nature Communications

The Motility of a Human Parasite, Toxoplasma gondii, Is Regulated by a Novel Lysine Methyltransferase

(2011) Aoife T. Heaslip et al.   PLoS Pathogens

In silico and biological survey of transcription-associated proteins implicated in the transcriptional machinery during the erythrocytic development of Plasmodium falciparum

(2010) Emmanuel Bischoff et al.   BMC GENOMICS

The Systematic Functional Analysis of Plasmodium Protein Kinases Identifies Essential Regulators of Mosquito Transmission

(2010) Rita Tewari et al.   Cell Host & Microbe

Integrative Genomic Approaches Highlight a Family of Parasite-Specific Kinases that Regulate Host Responses

(2010) Lucia Peixoto et al.   Cell Host & Microbe

ThePlasmodiumeukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary glands

(2010) Min Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The MYST family histone acetyltransferase regulates gene expression and cell cycle in malaria parasite Plasmodium falciparum

(2010) Jun Miao et al.   MOLECULAR MICROBIOLOGY

Small-molecule inhibition of APT1 affects Ras localization and signaling

(2010) Frank J Dekker et al.   Nature Chemical Biology

Erratum: Artemisinin resistance: current status and scenarios for containment

(2010) Arjen M. Dondorp et al.   NATURE REVIEWS MICROBIOLOGY

A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes

(2010) J. D. Dvorin et al.   SCIENCE

Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite

(2010) Kerstin Leykauf et al.   PLoS Pathogens

Characterization of PRMT1 fromPlasmodium falciparum

(2009) Qi Fan et al.   BIOCHEMICAL JOURNAL

Malaria: Targeting parasite and host cell kinomes

(2009) Christian Doerig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Genome-wide Analysis of Heterochromatin Associates Clonally Variant Gene Regulation with Perinuclear Repressive Centers in Malaria Parasites

(2009) Jose-Juan Lopez-Rubio et al.   Cell Host & Microbe

Potential epigenetic regulatory proteins localise to distinct nuclear sub-compartments in Plasmodium falciparum

(2009) Jennifer Volz et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Identification and Characterization of Small Molecule Inhibitors of a Class I Histone Deacetylase fromPlasmodium falciparum

(2009) Vishal Patel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global Histone Analysis by Mass Spectrometry Reveals a High Content of Acetylated Lysine Residues in the Malaria ParasitePlasmodium falciparum

(2009) Morten B. Trelle et al.   JOURNAL OF PROTEOME RESEARCH

PfeIK1, a eukaryotic initiation factor 2α kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation

(2009) Clare Fennell et al.   MALARIA JOURNAL

Large-scale profiling of protein palmitoylation in mammalian cells

(2009) Brent R Martin et al.   NATURE METHODS

Plasmodium falciparum heterochromatin protein 1 binds to tri-methylated histone 3 lysine 9 and is linked to mutually exclusive expression of var genes

(2009) K. Perez-Toledo et al.   NUCLEIC ACIDS RESEARCH

Dynamic histone H3 epigenome marking during the intraerythrocytic cycle of Plasmodium falciparum

(2009) A. M. Salcedo-Amaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sir2 Paralogues Cooperate to Regulate Virulence Genes and Antigenic Variation in Plasmodium falciparum

(2009) Christopher J Tonkin et al.   PLOS BIOLOGY

Plasmodium falciparum Heterochromatin Protein 1 Marks Genomic Loci Linked to Phenotypic Variation of Exported Virulence Factors

(2009) Christian Flueck et al.   PLoS Pathogens

Potent Antimalarial Activity of Histone Deacetylase Inhibitor Analogues

(2008) K. T. Andrews et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Plasmodium falciparumSir2 is an NAD+-Dependent Deacetylase and an Acetyllysine-Dependent and Acetyllysine-Independent NAD+Glycohydrolase†

(2008) Jarrod B. French et al.   BIOCHEMISTRY

The protein-phosphatome of the human malaria parasite Plasmodium falciparum

(2008) Jonathan M Wilkes et al.   BMC GENOMICS

SILAC Mouse for Quantitative Proteomics Uncovers Kindlin-3 as an Essential Factor for Red Blood Cell Function

(2008) Marcus Krüger et al.   CELL

Identification of a novel post-translational modification inPlasmodium falciparum: protein sumoylation in different cellular compartments

(2008) Neha Issar et al.   CELLULAR MICROBIOLOGY

Histone lysine methyltransferases and demethylases in Plasmodium falciparum

(2008) Liwang Cui et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility

(2008) Nobutaka Kato et al.   Nature Chemical Biology

Hot, sweet and sticky: the glycobiology of Plasmodium falciparum

(2008) Mark von Itzstein et al.   TRENDS IN PARASITOLOGY