An evolutionary perspective on the kinome of malaria parasites

Signalling in malaria parasites – The MALSIG consortium

(2013) C. Doerig et al.   Parasite

Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa

(2011) Eric Talevich et al.   BMC EVOLUTIONARY BIOLOGY

Protein-based signatures of functional evolution in Plasmodium falciparum

(2011) Kate B Gardner et al.   BMC EVOLUTIONARY BIOLOGY

The Cryptosporidium parvum Kinome

(2011) Jennifer D Artz et al.   BMC GENOMICS

The Phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii Reveal Unusual Adaptations Within and Beyond the Parasites' Boundaries

(2011) Moritz Treeck et al.   Cell Host & Microbe

Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes

(2011) Audrey Sicard et al.   CELLULAR MICROBIOLOGY

The State of the Art in Anti-Malarial Drug Discovery and Development

(2011) Jeremy N. Burrows et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes

(2011) J. Fasolo et al.   GENES & DEVELOPMENT

Plasmodium falciparum NIMA-related kinase Pfnek-1: sex specificity and assessment of essentiality for the erythrocytic asexual cycle

(2011) D. Dorin-Semblat et al.   MICROBIOLOGY-SGM

Jumbled Genomes: Missing Apicomplexan Synteny

(2011) J. D. DeBarry et al.   MOLECULAR BIOLOGY AND EVOLUTION

Interactive Tree Of Life v2: online annotation and display of phylogenetic trees made easy

(2011) I. Letunic et al.   NUCLEIC ACIDS RESEARCH

Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence

(2011) M. L. Reese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases

(2011) M. S. Behnke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

(2011) Lev Solyakov et al.   Nature Communications

The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology

(2011) Gerard Manning et al.   GENOME BIOLOGY

Malaria,Plasmodium falciparumand its apicoplast

(2010) Ming Kalanon et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Phosphotyrosine Signaling: Evolving a New Cellular Communication System

(2010) Wendell A. Lim et al.   CELL

The Systematic Functional Analysis of Plasmodium Protein Kinases Identifies Essential Regulators of Mosquito Transmission

(2010) Rita Tewari et al.   Cell Host & Microbe

Integrative Genomic Approaches Highlight a Family of Parasite-Specific Kinases that Regulate Host Responses

(2010) Lucia Peixoto et al.   Cell Host & Microbe

A Plasmodium falciparum Transcriptional Cyclin-Dependent Kinase-Related Kinase with a Crucial Role in Parasite Proliferation Associates with Histone Deacetylase Activity

(2010) Jean Halbert et al.   EUKARYOTIC CELL

DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles

(2010) Sergi Aranda et al.   FASEB JOURNAL

The Apicomplexan AP2 family: Integral factors regulating Plasmodium development

(2010) Heather J. Painter et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Low-Complexity Regions in Plasmodium falciparum: Missing Links in the Evolution of an Extreme Genome

(2010) M. M. Zilversmit et al.   MOLECULAR BIOLOGY AND EVOLUTION

Artemisinin resistance: current status and scenarios for containment

(2010) Arjen M. Dondorp et al.   NATURE REVIEWS MICROBIOLOGY

ParameciumDB in 2011: new tools and new data for functional and comparative genomics of the model ciliate Paramecium tetraurelia

(2010) O. Arnaiz et al.   NUCLEIC ACIDS RESEARCH

Plasmodium falciparum FIKK Kinase Members Target Distinct Components of the Erythrocyte Membrane

(2010) Marta C. Nunes et al.   PLoS One

Yet another "active" pseudokinase, Erb3

(2010) S. S. Taylor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes

(2010) J. D. Dvorin et al.   SCIENCE

Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite

(2010) Kerstin Leykauf et al.   PLoS Pathogens

Malaria: Targeting parasite and host cell kinomes

(2009) Christian Doerig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Rapid detection, classification and accurate alignment of up to a million or more related protein sequences

(2009) Andrew F. Neuwald   BIOINFORMATICS

Calcium-Dependent Signaling and Kinases in Apicomplexan Parasites

(2009) Oliver Billker et al.   Cell Host & Microbe

The Malaria Parasite Cyclic GMP-Dependent Protein Kinase Plays a Central Role in Blood-Stage Schizogony

(2009) Helen M. Taylor et al.   EUKARYOTIC CELL

Low Complexity Regions behave as tRNA sponges to help co-translational folding of plasmodial proteins

(2009) Magali Frugier et al.   FEBS LETTERS

An Essential Role for the Plasmodium Nek-2 Nima-related Protein Kinase in the Sexual Development of Malaria Parasites

(2009) Luc Reininger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissection of Mechanisms Involved in the Regulation ofPlasmodium falciparumCalcium-dependent Protein Kinase 4

(2009) Ravikant Ranjan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PfeIK1, a eukaryotic initiation factor 2α kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation

(2009) Clare Fennell et al.   MALARIA JOURNAL

Protein Kinase Activation Loop Autophosphorylation in Cis: Overcoming a Catch-22 Situation

(2009) P. A. Lochhead   Science Signaling

Consistent and contrasting properties of lineage-specific genes in the apicomplexan parasites Plasmodium and Theileria

(2008) Chih-Horng Kuo et al.   BMC EVOLUTIONARY BIOLOGY

Rethinking Pseudokinases

(2008) Natarajan Kannan et al.   CELL

CASK Functions as a Mg2+-Independent Neurexin Kinase

(2008) Konark Mukherjee et al.   CELL

The Motor Complex ofPlasmodium falciparum

(2008) Judith L. Green et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Apicomplexan Whole-Genome Phylogeny: An Analysis of Incongruence among Gene Trees

(2008) C.-H. Kuo et al.   MOLECULAR BIOLOGY AND EVOLUTION

Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility

(2008) Nobutaka Kato et al.   Nature Chemical Biology

Plasmodium falciparum Regulatory Subunit of cAMP-Dependent PKA and Anion Channel Conductance

(2008) Anaïs Merckx et al.   PLoS Pathogens

Structures of P. falciparum Protein Kinase 7 Identify an Activation Motif and Leads for Inhibitor Design

(2008) Anais Merckx et al.   STRUCTURE