Plasmodiumkinases as targets for new-generation antimalarials

Chemical Proteomic Analysis Reveals the Drugability of the Kinome of Trypanosoma brucei

(2012) Michael D. Urbaniak et al.   ACS Chemical Biology

An All-Purpose Antimalarial Drug Target

(2012) W. Armand Guiguemde et al.   Cell Host & Microbe

Global Phenotypic Screening for Antimalarials

(2012) W. Armand Guiguemde et al.   CHEMISTRY & BIOLOGY

Targeting Protein Kinases in the Malaria Parasite: Update of an Antimalarial Drug Target

(2012) Veronica M. Zhang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Back to the Future: Lessons Learned in Modern Target-based and Whole-Cell Lead Optimization of Antimalarials

(2012) Arnab K. Chatterjee et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors

(2012) Kayode K. Ojo et al.   JOURNAL OF CLINICAL INVESTIGATION

Lead Optimization of Antimalarial Propafenone Analogues

(2012) David Lowes et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Novel Antimalarial Chemotypes via Chemoinformatic Compound Selection Methods for a High-Throughput Screening Program against the Novel Malarial Target, PfNDH2: Increasing Hit Rate via Virtual Screening Methods

(2012) Raman Sharma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lead Optimization of 3-Carboxyl-4(1H)-Quinolones to Deliver Orally Bioavailable Antimalarials

(2012) Yiqun Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Plasmodium falciparum Schizont Phosphoproteome Reveals Extensive Phosphatidylinositol and cAMP-Protein Kinase A Signaling

(2012) Edwin Lasonder et al.   JOURNAL OF PROTEOME RESEARCH

Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target

(2012) Nina M. Haste et al.   MICROBES AND INFECTION

Insights into the Plasmodium falciparum schizont phospho-proteome

(2012) Edwin Lasonder et al.   MICROBES AND INFECTION

The kinomes of apicomplexan parasites

(2012) Diego Miranda-Saavedra et al.   MICROBES AND INFECTION

The role of cGMP signalling in regulating life cycle progression of Plasmodium

(2012) Christine S. Hopp et al.   MICROBES AND INFECTION

An evolutionary perspective on the kinome of malaria parasites

(2012) E. Talevich et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Regulation of Plasmodium falciparum Glideosome Associated Protein 45 (PfGAP45) Phosphorylation

(2012) Divya Catherine Thomas et al.   PLoS One

The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium: A Comparative Study with Human and Rodent Parasites

(2012) Michael Delves et al.   PLOS MEDICINE

Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa

(2011) Eric Talevich et al.   BMC EVOLUTIONARY BIOLOGY

The Phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii Reveal Unusual Adaptations Within and Beyond the Parasites' Boundaries

(2011) Moritz Treeck et al.   Cell Host & Microbe

Advancing cancer drug discovery towards more agile development of targeted combination therapies

(2011) Neil O Carragher et al.   Future Medicinal Chemistry

Two nucleus-localized CDK-like kinases with crucial roles for malaria parasite erythrocytic replication are involved in phosphorylation of splicing factor

(2011) Shruti Agarwal et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Plasmodium falciparum NIMA-related kinase Pfnek-1: sex specificity and assessment of essentiality for the erythrocytic asexual cycle

(2011) D. Dorin-Semblat et al.   MICROBIOLOGY-SGM

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

(2011) Lev Solyakov et al.   Nature Communications

The Systematic Functional Analysis of Plasmodium Protein Kinases Identifies Essential Regulators of Mosquito Transmission

(2010) Rita Tewari et al.   Cell Host & Microbe

SAM domain-dependent activity of PfTKL3, an essential tyrosine kinase-like kinase of the human malaria parasite Plasmodium falciparum

(2010) Abdirahman Abdi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tinkering outside the kinase ATP box: allosteric (type IV) and bivalent (type V) inhibitors of protein kinases

(2010) Kurt J Cox et al.   Future Medicinal Chemistry

PfSRPK1, a Novel Splicing-related Kinase fromPlasmodium falciparum

(2010) Aparna Dixit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The malarial CDK Pfmrk and its effector PfMAT1 phosphorylate DNA replication proteins and co-localize in the nucleus

(2010) Dayadevi Jirage et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

An essential Aurora-related kinase transiently associates with spindle pole bodies during Plasmodium falciparum erythrocytic schizogony

(2010) Luc Reininger et al.   MOLECULAR MICROBIOLOGY

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

(2010) Sebastian Lourido et al.   NATURE

Erratum: Artemisinin resistance: current status and scenarios for containment

(2010) Arjen M. Dondorp et al.   NATURE REVIEWS MICROBIOLOGY

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

(2010) Amy K Wernimont et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Plasmodium falciparum FIKK Kinase Members Target Distinct Components of the Erythrocyte Membrane

(2010) Marta C. Nunes et al.   PLoS One

Structures of parasitic CDPK domains point to a common mechanism of activation

(2010) Amy K. Wernimont et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Is the Tide Turning for New Malaria Medicines?

(2010) T. N. C. Wells   SCIENCE

A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes

(2010) J. D. Dvorin et al.   SCIENCE

Identification and Characterization of Novel Small Molecules as Potent Inhibitors of the Plasmodial Calcium-Dependent Protein Kinase 1

(2009) Guillaume Lemercier et al.   BIOCHEMISTRY

Malaria: Targeting parasite and host cell kinomes

(2009) Christian Doerig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones

(2009) Jeanne A. Geyer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Calcium-Dependent Signaling and Kinases in Apicomplexan Parasites

(2009) Oliver Billker et al.   Cell Host & Microbe

The Malaria Parasite Cyclic GMP-Dependent Protein Kinase Plays a Central Role in Blood-Stage Schizogony

(2009) Helen M. Taylor et al.   EUKARYOTIC CELL

An Essential Role for the Plasmodium Nek-2 Nima-related Protein Kinase in the Sexual Development of Malaria Parasites

(2009) Luc Reininger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissection of Mechanisms Involved in the Regulation ofPlasmodium falciparumCalcium-dependent Protein Kinase 4

(2009) Ravikant Ranjan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antiplasmodial Activities of Homogentisic Acid Derivative Protein Kinase Inhibitors Isolated from a Vanuatu Marine Sponge Pseudoceratina sp.

(2009) Nicolas Lebouvier et al.   Marine Drugs

Protein kinase inhibitors: contributions from structure to clinical compounds

(2009) Louise N. Johnson   QUARTERLY REVIEWS OF BIOPHYSICS

Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7

(2008) Nathalie Bouloc et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Assessment of Chemical Coverage of Kinome Space and Its Implications for Kinase Drug Discovery

(2008) Paul Bamborough et al.   JOURNAL OF MEDICINAL CHEMISTRY

Alisiaquinones and Alisiaquinol, Dual Inhibitors ofPlasmodium falciparumEnzyme Targets from a New Caledonian Deep Water Sponge

(2008) Denis Desoubzdanne et al.   JOURNAL OF NATURAL PRODUCTS

Heterologous expression of plasmodial proteins for structural studies and functional annotation

(2008) Lyn-Marie Birkholtz et al.   MALARIA JOURNAL

Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility

(2008) Nobutaka Kato et al.   Nature Chemical Biology

In silicoactivity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

(2008) David Plouffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of P. falciparum Protein Kinase 7 Identify an Activation Motif and Leads for Inhibitor Design

(2008) Anais Merckx et al.   STRUCTURE

Drugging the Plasmodium kinome: the benefits of academia–industry synergy

(2008) Didier Leroy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Gametogenesis in Malaria Parasites Is Mediated by the cGMP-Dependent Protein Kinase

(2008) Louisa McRobert et al.   PLOS BIOLOGY