Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor

Relationship between Postoperative Recurrence Rate and Eosinophil Density of Nasal Polyps

(2014) Fuat Tosun et al.   ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY

Long-Term Budesonide Maintenance Treatment Is Partially Effective for Patients With Eosinophilic Esophagitis

(2011) Alex Straumann et al.   Clinical Gastroenterology and Hepatology

Eosinophilic esophagitis: Updated consensus recommendations for children and adults

(2011) Chris A. Liacouras et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Eosinophils in innate immunity: an evolving story

(2010) Revital Shamri et al.   CELL AND TISSUE RESEARCH

Eosinophils in health and disease: the LIAR hypothesis

(2010) J. J. Lee et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Effect of IL-4 and interferon-gamma (IFN-γ) on IL-3- and IL-5-induced eosinophil differentiation from human cord blood mononuclear cells

(2010) K. OCHIAI et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Local proliferation and mobilization of CCR3+ CD34+ eosinophil-lineage-committed cells in the lung

(2010) Madeleine Rådinger et al.   IMMUNOLOGY

Reslizumab for pediatric eosinophilic esophagitis

(2010) Garry M Walsh   Immunotherapy

Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti–IL-5 receptor α antibody, in a phase I study of subjects with mild asthma

(2010) William W. Busse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mepolizumab as a corticosteroid-sparing agent in lymphocytic variant hypereosinophilic syndrome

(2010) Florence Roufosse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mepolizumab as a steroid-sparing treatment option in patients with Churg-Strauss syndrome

(2010) Sophia Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mepolizumab does not alter levels of eosinophils, T cells, and mast cells in the duodenal mucosa in eosinophilic esophagitis

(2010) Sébastien Conus et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function

(2010) Roland Kolbeck et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Decreases in human dendritic cell–dependent TH2-like responses after acute in vivo IgE neutralization

(2010) John T. Schroeder et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-β1, and increase esophageal smooth muscle contraction

(2010) Seema S. Aceves et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mepolizumab in refractory eosinophilic asthma

(2010) I D Pavord et al.   THORAX

Differential expression of the interleukin 5 receptor α isoforms in blood and tissue eosinophils of nasal polyp patients

(2009) P. Gevaert et al.   ALLERGY

The hypereosinophilic syndromes: current concepts and treatments

(2009) Gerald J. Gleich et al.   BRITISH JOURNAL OF HAEMATOLOGY

Fluvastatin inhibits expression of the chemokine MDC/CCL22 induced by interferon-γ in HaCaT cells, a human keratinocyte cell line

(2009) Xu-Feng Qi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Haemopoietic processes in allergic disease: eosinophil/basophil development

(2009) G. M. Gauvreau et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses

(2009) Y.-H. Wang et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Mepolizumab and Eosinophil-Mediated Disease

(2009) G. Walsh   CURRENT MEDICINAL CHEMISTRY

Mepolizumab for difficult-to-control asthma with persistent sputum eosinophilia

(2009) Sabina A Antoniu   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial

(2009) A Straumann et al.   GUT

IL-5- and eosinophil-mediated inflammation: from discovery to therapy

(2009) T. Kouro et al.   INTERNATIONAL IMMUNOLOGY

Immunomodulator therapy: Monoclonal antibodies, fusion proteins, cytokines, and immunoglobulins

(2009) Susan J. Lee et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgE Influences the Number and Function of Mature Mast Cells, but Not Progenitor Recruitment in Allergic Pulmonary Inflammation

(2009) C. B. Mathias et al.   JOURNAL OF IMMUNOLOGY

The adenylyl cyclase-cAMP system suppresses TARC/CCL17 and MDC/CCL22 production through p38 MAPK and NF-κB in HaCaT keratinocytes

(2009) Xu-Feng Qi et al.   MOLECULAR IMMUNOLOGY

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

(2009) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intrinsic pathway of apoptosis in peripheral blood eosinophils of Churg–Strauss syndrome

(2009) Bogdan Jakiela et al.   RHEUMATOLOGY

New Production of Eosinophils and the Corresponding Th1/Th2 Balance in the Lungs after Allergen Exposure in BALB/cand C57BL/6 Mice

(2009) Y. Lu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Efficacy of omalizumab in the treatment of atopic dermatitis: A pilot study

(2008) Lee E. Sheinkopf et al.   ALLERGY AND ASTHMA PROCEEDINGS

Treatment With Topical Steroids Downregulates IL-5, Eotaxin-1/CCL11, and Eotaxin-3/CCL26 Gene Expression in Eosinophilic Esophagitis

(2008) Alfredo J Lucendo et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Antisense Therapy against CCR3 and the Common Beta Chain Attenuates Allergen-induced Eosinophilic Responses

(2008) Gail M. Gauvreau et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immunomodulatory therapy of eosinophil-associated gastrointestinal diseases

(2008) K. D. Stone et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Epidemiologic, Experimental, and Clinical Links between Respiratory Syncytial Virus Infection and Asthma

(2008) S. S. Mohapatra et al.   CLINICAL MICROBIOLOGY REVIEWS

Allergy and eosinophil-associated gastrointestinal disorders (EGID)

(2008) Charles W DeBrosse et al.   CURRENT OPINION IN IMMUNOLOGY

IL-5 and eosinophilia

(2008) Kiyoshi Takatsu et al.   CURRENT OPINION IN IMMUNOLOGY

Structure-Based Rationale for Interleukin 5 Receptor Antagonism

(2008) Tetsuya Ishino et al.   CURRENT PHARMACEUTICAL DESIGN

Small interfering RNA against interleukin-5 decreases airway eosinophilia and hyper-responsiveness

(2008) H-Y Huang et al.   GENE THERAPY

Interferon-γ enhances human eosinophil effector functions induced by granulocyte-macrophage colony-stimulating factor or interleukin-5

(2008) Takafumi Yamaguchi et al.   IMMUNOLOGY LETTERS

Differences in regulatory T cells between Churg-Strauss syndrome and chronic eosinophilic pneumonia with asthma

(2008) Naomi Tsurikisawa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anti–IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels

(2008) Miguel L. Stein et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation

(2008) Zoulfia Allakhverdi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin-5 Receptor Subunit Oligomerization and Rearrangement Revealed by Fluorescence Resonance Energy Transfer Imaging

(2008) Meirav Zaks-Zilberman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Short hairpin RNAs against eotaxin or interleukin-5 decrease airway eosinophilia and hyper-responsiveness in a murine model of asthma

(2008) Hsin-Ying Huang et al.   JOURNAL OF GENE MEDICINE

Treatment of Patients with the Hypereosinophilic Syndrome with Mepolizumab

(2008) Marc E. Rothenberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Eosinophil progenitors in allergy and asthma — Do they matter?

(2008) Madeleine Rådinger et al.   PHARMACOLOGY & THERAPEUTICS

Mepolizumab

(2008) &NA;   Drugs in research & development

Chronic bronchitis sub-phenotype within COPD: inflammation in sputum and biopsies

(2007) J. B. Snoeck-Stroband et al.   EUROPEAN RESPIRATORY JOURNAL