Biological targets and mechanisms of action of natural products from marine cyanobacteria

Evaluation of class I HDAC isoform selectivity of largazole analogues

(2014) Bumki Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Grassypeptolides as Natural Inhibitors of Dipeptidyl Peptidase 8 and T-Cell Activation

(2014) Jason C. Kwan et al.   CHEMBIOCHEM

Improved Total Synthesis and Biological Evaluation of Potent Apratoxin S4 Based Anticancer Agents with Differential Stability and Further Enhanced Activity

(2014) Qi-Yin Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties

(2014) Lilibeth A. Salvador et al.   ACS Medicinal Chemistry Letters

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis and Biological Evaluation of Grassypeptolide A

(2013) Hui Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pharmaceutical agents from filamentous marine cyanobacteria

(2013) Lik Tong Tan   DRUG DISCOVERY TODAY

Potent Elastase Inhibitors from Cyanobacteria: Structural Basis and Mechanisms Mediating Cytoprotective and Anti-Inflammatory Effects in Bronchial Epithelial Cells

(2013) Lilibeth A. Salvador et al.   JOURNAL OF MEDICINAL CHEMISTRY

Examination of the Mode of Action of the Almiramide Family of Natural Products against the Kinetoplastid Parasite Trypanosoma brucei

(2013) Laura M. Sanchez et al.   JOURNAL OF NATURAL PRODUCTS

Santacruzamate A, a Potent and Selective Histone Deacetylase Inhibitor from the Panamanian Marine Cyanobacterium cf. Symploca sp.

(2013) Christopher M. Pavlik et al.   JOURNAL OF NATURAL PRODUCTS

The Marine Cyanobacterial Metabolite Gallinamide A Is a Potent and Selective Inhibitor of Human Cathepsin L

(2013) Bailey Miller et al.   JOURNAL OF NATURAL PRODUCTS

Is copper chelation an effective anti-angiogenic strategy for cancer treatment?

(2013) V. Antoniades et al.   MEDICAL HYPOTHESES

Target identification of small molecules based on chemical biology approaches

(2013) Yushi Futamura et al.   Molecular BioSystems

From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes

(2013) Kyung Bo Kim et al.   NATURAL PRODUCT REPORTS

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

Modular Strategies for Structure and Function Employed by Marine Cyanobacteria: Characterization and Synthesis of Pitinoic Acids

(2013) Rana Montaser et al.   ORGANIC LETTERS

Total synthesis of grassystatin A, a probe for cathepsin E function

(2012) Siming Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Quorum sensing inhibitors: An overview

(2012) Vipin Chandra Kalia   BIOTECHNOLOGY ADVANCES

The Carmaphycins: New Proteasome Inhibitors Exhibiting an α,β-Epoxyketone Warhead from a Marine Cyanobacterium

(2012) Alban R. Pereira et al.   CHEMBIOCHEM

Total synthesis and stereochemical revision of lagunamide A

(2012) Lu Dai et al.   CHEMICAL COMMUNICATIONS

The Antimalarial Natural Product Symplostatin 4 Is a Nanomolar Inhibitor of the Food Vacuole Falcipains

(2012) Sara Christina Stolze et al.   CHEMISTRY & BIOLOGY

Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology

(2012) William H. Gerwick et al.   CHEMISTRY & BIOLOGY

Morphobase, an Encyclopedic Cell Morphology Database, and Its Use for Drug Target Identification

(2012) Yushi Futamura et al.   CHEMISTRY & BIOLOGY

Honaucins A−C, Potent Inhibitors of Inflammation and Bacterial Quorum Sensing: Synthetic Derivatives and Structure-Activity Relationships

(2012) Hyukjae Choi et al.   CHEMISTRY & BIOLOGY

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

(2012) Alexei F. Kisselev et al.   CHEMISTRY & BIOLOGY

Discovery and Mechanism of Natural Products as Modulators of Histone Acetylation

(2012) Lilibeth A. Salvador et al.   CURRENT DRUG TARGETS

Cyanobacterial Peptides as a Prototype for the Design of Potent β-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases

(2012) Yanxia Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Symplocin A, a Linear Peptide from the Bahamian Cyanobacterium Symploca sp. Configurational Analysis of N,N-Dimethylamino Acids by Chiral-Phase HPLC of Naphthacyl Esters

(2012) Tadeusz F. Molinski et al.   JOURNAL OF NATURAL PRODUCTS

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling

(2012) Yuqing Liu et al.   LIVER INTERNATIONAL

Largazole: From discovery to broad-spectrum therapy

(2012) Jiyong Hong et al.   NATURAL PRODUCT REPORTS

The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

(2012) Peter D Senter et al.   NATURE BIOTECHNOLOGY

Using transcriptome sequencing to identify mechanisms of drug action and resistance

(2012) Sarah A Wacker et al.   Nature Chemical Biology

Target-based drug discovery, genetic diseases, and biologics

(2012) Orest Hurko   NEUROCHEMISTRY INTERNATIONAL

Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms

(2012) M E Law et al.   ONCOGENE

Largazole and Its Derivatives Selectively Inhibit Ubiquitin Activating Enzyme (E1)

(2012) Dana Ungermannova et al.   PLoS One

Cell-Morphology Profiling of a Natural Product Library Identifies Bisebromoamide and Miuraenamide A as Actin Filament Stabilizers

(2011) Eriko Sumiya et al.   ACS Chemical Biology

Actin Structure and Function

(2011) Roberto Dominguez et al.   Annual Review of Biophysics

Chemical Genetics–Based Target Identification in Drug Discovery

(2011) Feng Cong et al.   Annual Review of Pharmacology and Toxicology

Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction

(2011) Karla L. Malloy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 alpha subunits

(2011) Zhengyu Cao et al.   BMC NEUROSCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The secret life of kinases: functions beyond catalysis

(2011) Jens Rauch et al.   Cell Communication and Signaling

Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin

(2011) Shin-ichi Sato et al.   CHEMISTRY & BIOLOGY

Total Synthesis, Stereochemical Assignment, and Antimalarial Activity of Gallinamide A

(2011) Trent Conroy et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chemodiversity in Freshwater and Terrestrial Cyanobacteria – A Source for Drug Discovery

(2011) George E. Chlipala et al.   CURRENT DRUG TARGETS

Structural Basis of the Antiproliferative Activity of Largazole, a Depsipeptide Inhibitor of the Histone Deacetylases

(2011) Kathryn E. Cole et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lyngbyoic acid, a “tagged” fatty acid from a marine cyanobacterium, disrupts quorum sensing in Pseudomonas aeruginosa

(2011) Jason Christopher Kwan et al.   Molecular BioSystems

Lagunamide C, a cytotoxic cyclodepsipeptide from the marine cyanobacterium Lyngbya majuscula

(2011) Ashootosh Tripathi et al.   PHYTOCHEMISTRY

Systematic Chemical Mutagenesis Identifies a Potent Novel Apratoxin A/E Hybrid with Improved in Vivo Antitumor Activity

(2011) Qi-Yin Chen et al.   ACS Medicinal Chemistry Letters

In Vitro and In Vivo Osteogenic Activity of Largazole

(2011) Su-Ui Lee et al.   ACS Medicinal Chemistry Letters

Natural Products as Chemical Probes

(2010) Erin E. Carlson   ACS Chemical Biology

Therapeutic potential of activators and inhibitors of sirtuins

(2010) Aneta Balcerczyk et al.   BIOFACTORS

Evolved Diversification of a Modular Natural Product Pathway: Apratoxins F and G, Two Cytotoxic Cyclic Depsipeptides from a Palmyra Collection of Lyngbya bouillonii

(2010) Kevin Tidgewell et al.   CHEMBIOCHEM

Biochemical Target Isolation for Novices: Affinity-Based Strategies

(2010) Shin-ichi Sato et al.   CHEMISTRY & BIOLOGY

Weapons in Disguise-Activating Mechanisms and Protecting Group Chemistry in Nature

(2010) Jason C. Kwan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Filamentous tropical marine cyanobacteria: a rich source of natural products for anticancer drug discovery

(2010) Lik Tong Tan   JOURNAL OF APPLIED PHYCOLOGY

Almiramides A−C: Discovery and Development of a New Class of Leishmaniasis Lead Compounds

(2010) Laura M. Sanchez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cytotoxic Halogenated Macrolides and Modified Peptides from the Apratoxin-Producing Marine CyanobacteriumLyngbya bouilloniifrom Guam

(2010) Susan Matthew et al.   JOURNAL OF NATURAL PRODUCTS

The Hoiamides, Structurally Intriguing Neurotoxic Lipopeptides from Papua New Guinea Marine Cyanobacteria

(2010) Hyukjae Choi et al.   JOURNAL OF NATURAL PRODUCTS

Lagunamides A and B: Cytotoxic and Antimalarial Cyclodepsipeptides from the Marine CyanobacteriumLyngbya majuscula

(2010) Ashootosh Tripathi et al.   JOURNAL OF NATURAL PRODUCTS

Grassypeptolides A−C, Cytotoxic Bis-thiazoline Containing Marine Cyclodepsipeptides

(2010) Jason C. Kwan et al.   JOURNAL OF ORGANIC CHEMISTRY

Anticolon Cancer Activity of Largazole, a Marine-Derived Tunable Histone Deacetylase Inhibitor

(2010) Y. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Microtubule-binding agents: a dynamic field of cancer therapeutics

(2010) Charles Dumontet et al.   NATURE REVIEWS DRUG DISCOVERY

Total Synthesis and Antimalarial Activity of Symplostatin 4

(2010) Trent Conroy et al.   ORGANIC LETTERS

Palmyrolide A, an Unusually Stabilized Neuroactive Macrolide from Palmyra Atoll Cyanobacteria

(2010) Alban R. Pereira et al.   ORGANIC LETTERS

Malyngolide from the cyanobacterium Lyngbya majuscula interferes with quorum sensing circuitry

(2010) Sergey Dobretsov et al.   Environmental Microbiology Reports

Combinatorial Strategies by Marine Cyanobacteria: Symplostatin 4, an Antimitotic Natural Dolastatin 10/15 Hybrid that Synergizes with the Coproduced HDAC Inhibitor Largazole

(2009) Kanchan Taori et al.   CHEMBIOCHEM

Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria

(2009) Alban Pereira et al.   CHEMISTRY & BIOLOGY

Epigenetic Therapy: Histone Acetylation, DNA Methylation and Anti-Cancer Drug Discovery

(2009) A. Ganesan et al.   CURRENT CANCER DRUG TARGETS

Trypanocidal drugs: mechanisms, resistance and new targets

(2009) Shane R. Wilkinson et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Cyclodepsipeptide toxin promotes the degradation of Hsp90 client proteins through chaperone-mediated autophagy

(2009) Shensi Shen et al.   JOURNAL OF CELL BIOLOGY

Grassystatins A−C from Marine Cyanobacteria, Potent Cathepsin E Inhibitors That Reduce Antigen Presentation

(2009) Jason C. Kwan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimalarial Peptides from Marine Cyanobacteria: Isolation and Structural Elucidation of Gallinamide A

(2009) Roger G. Linington et al.   JOURNAL OF NATURAL PRODUCTS

Structural and Synthetic Investigations of Tanikolide Dimer, a SIRT2 Selective Inhibitor, and Tanikolideseco-Acid from the Madagascar Marine CyanobacteriumLyngbya majuscula

(2009) Marcelino Gutiérrez et al.   JOURNAL OF ORGANIC CHEMISTRY

Antillatoxin, a Novel Lipopeptide, Enhances Neurite Outgrowth in Immature Cerebrocortical Neurons through Activation of Voltage-Gated Sodium Channels

(2009) S. V. Jabba et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Apratoxin A Reversibly Inhibits the Secretory Pathway by Preventing Cotranslational Translocation

(2009) Y. Liu et al.   MOLECULAR PHARMACOLOGY

Target profiling of small molecules by chemical proteomics

(2009) Uwe Rix et al.   Nature Chemical Biology

Kinase mutations in human disease: interpreting genotype–phenotype relationships

(2009) Piya Lahiry et al.   NATURE REVIEWS GENETICS

Bisebromoamide, a Potent Cytotoxic Peptide from the Marine CyanobacteriumLyngbyasp.: Isolation, Stereostructure, and Biological Activity

(2009) Toshiaki Teruya et al.   ORGANIC LETTERS

Alotamide A, a Novel Neuropharmacological Agent from the Marine CyanobacteriumLyngbya bouillonii

(2009) Irma E. Soria-Mercado et al.   ORGANIC LETTERS

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical mechanisms of histone lysine and arginine modifications

(2008) Brian C. Smith et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives

(2008) Malcolm W.B. McCulloch et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mechanisms and Molecular Probes of Sirtuins

(2008) Brian C. Smith et al.   CHEMISTRY & BIOLOGY

Density functional theory studies of oxygen and carbonate binding to a dicopper patellamide complex

(2008) Reza Latifi et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Apratoxin E, a Cytotoxic Peptolide from a Guamanian Collection of the Marine CyanobacteriumLyngbya bouillonii

(2008) Susan Matthew et al.   JOURNAL OF NATURAL PRODUCTS

Apratoxin D, a Potent Cytotoxic Cyclodepsipeptide from Papua New Guinea Collections of the Marine CyanobacteriaLyngbya majusculaandLyngbya sordida

(2008) Marcelino Gutiérrez et al.   JOURNAL OF NATURAL PRODUCTS

Natural Products Chemistry and Taxonomy of the Marine CyanobacteriumBlennothrix cantharidosmum

(2008) Benjamin R. Clark et al.   JOURNAL OF NATURAL PRODUCTS

Total Synthesis and Molecular Target of Largazole, a Histone Deacetylase Inhibitor

(2008) Yongcheng Ying et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis and Biological Mode of Action of Largazole: A Potent Class I Histone Deacetylase Inhibitor

(2008) Albert Bowers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and Activity of Largazole, a Potent Antiproliferative Agent from the Floridian Marine CyanobacteriumSymplocasp.

(2008) Kanchan Taori et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Activity of Largazole Analogues with Linker and Macrocycle Modification

(2008) Yongcheng Ying et al.   ORGANIC LETTERS

Total Structure Determination of Grassypeptolide, a New Marine Cyanobacterial Cytotoxin

(2008) Jason C. Kwan et al.   ORGANIC LETTERS