Antiviral drug discovery: broad-spectrum drugs from nature

The Combination of Alisporivir plus an NS5A Inhibitor Provides Additive to Synergistic Anti-Hepatitis C Virus Activity without Detectable Cross-Resistance

(2014) Udayan Chatterji et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Towards hepatitis C eradication from the HIV-infected population

(2014) Pablo Barreiro et al.   ANTIVIRAL RESEARCH

Arbidol as a broad-spectrum antiviral: An update

(2014) Julie Blaising et al.   ANTIVIRAL RESEARCH

Benzophenone C-glucosides and gallotannins from mango tree stem bark with broad-spectrum anti-viral activity

(2014) Wael M. Abdel-Mageed et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dual anti-HSV and anti-HIV activity of the lantibiotic Labyrinthopeptin A1

(2014) Geoffrey Férir et al.   BMC INFECTIOUS DISEASES

Calcineurin Inhibitors Stimulate and Mycophenolic Acid Inhibits Replication of Hepatitis E Virus

(2014) Yijin Wang et al.   GASTROENTEROLOGY

Protective effect of fluvastatin on influenza virus infection

(2014) JING PENG et al.   Molecular Medicine Reports

Antibiotics from myxobacteria

(2014) Till F. Schäberle et al.   NATURAL PRODUCT REPORTS

Marine natural products

(2014) John W. Blunt et al.   NATURAL PRODUCT REPORTS

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430

(2014) Travis K. Warren et al.   NATURE

Emergence of Zaire Ebola Virus Disease in Guinea

(2014) Sylvain Baize et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preventing and Controlling Influenza with Available Interventions

(2014) Timothy M. Uyeki   NEW ENGLAND JOURNAL OF MEDICINE

Therapy for Hepatitis C — The Costs of Success

(2014) Jay H. Hoofnagle et al.   NEW ENGLAND JOURNAL OF MEDICINE

MERS: emergence of a novel human coronavirus

(2014) V Stalin Raj et al.   Current Opinion in Virology

The clinical significance of drug-drug interactions in the era of direct-acting anti-viral agents against chronic hepatitis C

(2013) B. Maasoumy et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Decrease of Virus Receptors during Highly Pathogenic H5N1 Virus Infection in Humans and Other Mammals

(2013) Debby van Riel et al.   AMERICAN JOURNAL OF PATHOLOGY

Activity of and Effect of Subcutaneous Treatment with the Broad-Spectrum Antiviral Lectin Griffithsin in Two Laboratory Rodent Models

(2013) Christopher Barton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Curing a viral infection by targeting the host: The example of cyclophilin inhibitors

(2013) Kai Lin et al.   ANTIVIRAL RESEARCH

Treating influenza with statins and other immunomodulatory agents

(2013) David S. Fedson   ANTIVIRAL RESEARCH

Antiviral therapies targeting host ER alpha-glucosidases: Current status and future directions

(2013) Jinhong Chang et al.   ANTIVIRAL RESEARCH

Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses

(2013) Jinhong Chang et al.   ANTIVIRAL RESEARCH

Drug–drug interactions in HIV therapy: is it all clear?

(2013) David Burger et al.   ANTIVIRAL THERAPY

Review of drug interactions with telaprevir and antiretrovirals

(2013) Rolf PG van Heeswijk et al.   ANTIVIRAL THERAPY

Structural and Functional Analysis of the Pro-Domain of Human Cathelicidin, LL-37

(2013) Marzena Pazgier et al.   BIOCHEMISTRY

Glycosaminoglycans in infectious disease

(2013) Eyal Kamhi et al.   BIOLOGICAL REVIEWS

Cyclophilin inhibitors as antiviral agents

(2013) Michael Peel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Containing the accidental laboratory escape of potential pandemic influenza viruses

(2013) Stefano Merler et al.   BMC Medicine

Broad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses that use glycosaminoglycans for entry

(2013) Liang-Tzung Lin et al.   BMC MICROBIOLOGY

Dynamins Are Forever: MxB Inhibits HIV-1

(2013) Otto Haller   Cell Host & Microbe

Virus Budding and the ESCRT Pathway

(2013) Jörg Votteler et al.   Cell Host & Microbe

Heterologous Expression and Engineering Studies of Labyrinthopeptins, Class III Lantibiotics from Actinomadura namibiensis

(2013) Joanna M. Krawczyk et al.   CHEMISTRY & BIOLOGY

Viral Infection Controlled by a Calcium-Dependent Lipid-Binding Module in ALIX

(2013) Christin Bissig et al.   DEVELOPMENTAL CELL

The importance of drug–drug interactions in the DAA era

(2013) David Back et al.   DIGESTIVE AND LIVER DISEASE

Antiviral potential of cathelicidins

(2013) Peter G Barlow et al.   Future Microbiology

HIV and co-infections

(2013) Christina C. Chang et al.   IMMUNOLOGICAL REVIEWS

Antibiotics in the clinical pipeline in 2013

(2013) Mark S Butler et al.   JOURNAL OF ANTIBIOTICS

Non-nucleoside reverse transcriptase inhibitor (NNRTI) cross-resistance: implications for preclinical evaluation of novel NNRTIs and clinical genotypic resistance testing

(2013) George L. Melikian et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Boosting HIV Treatment Options: Good News, New Challenges

(2013) Pedro Cahn et al.   JOURNAL OF INFECTIOUS DISEASES

Antiviral Resistance and the Future Landscape of Hepatitis C Virus Infection Therapy

(2013) David L. Wyles   JOURNAL OF INFECTIOUS DISEASES

CD8 down-regulation and functional impairment of SIV-specific cytotoxic T lymphocytes in lymphoid and mucosal tissues during SIV infection

(2013) Huanbin Xu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Antiviral Mechanisms of Human Defensins

(2013) Sarah S. Wilson et al.   JOURNAL OF MOLECULAR BIOLOGY

Concerted Action of P450 Plus Helper Protein To Form the Amino-hydroxy-piperidone Moiety of the Potent Protease Inhibitor Crocapeptin

(2013) Konrad Viehrig et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Filoviruses Utilize Glycosaminoglycans for Their Attachment to Target Cells

(2013) B. Salvador et al.   JOURNAL OF VIROLOGY

Griffithsin Protects Mice from Genital Herpes by Preventing Cell-to-Cell Spread

(2013) B. Nixon et al.   JOURNAL OF VIROLOGY

The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells

(2013) Georgios Kallifatidis et al.   Marine Drugs

Identification of myxobacteria-derived HIV inhibitors by a high-throughput two-step infectivity assay

(2013) Javier P Martinez et al.   Microbial Cell Factories

Industrial natural product chemistry for drug discovery and development

(2013) Armin Bauer et al.   NATURAL PRODUCT REPORTS

Cell biology: Beneficial lessons from viruses

(2013) Adolfo García-Sastre   NATURE

A pathogenic picornavirus acquires an envelope by hijacking cellular membranes

(2013) Zongdi Feng et al.   NATURE

The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

Novel therapies for hepatitis C — one pill fits all?

(2013) Michael P. Manns et al.   NATURE REVIEWS DRUG DISCOVERY

Drug–drug interactions during antiviral therapy for chronic hepatitis C

(2013) Jennifer J. Kiser et al.   Nature Reviews Gastroenterology & Hepatology

A mastoparan-derived peptide has broad-spectrum antiviral activity against enveloped viruses

(2013) Christopher J. Sample et al.   PEPTIDES

The Lantibiotic Peptide Labyrinthopeptin A1 Demonstrates Broad Anti-HIV and Anti-HSV Activity with Potential for Microbicidal Applications

(2013) Geoffrey Férir et al.   PLoS One

Genome-wide RNAi screen reveals a role for the ESCRT complex in rotavirus cell entry

(2013) D. Silva-Ayala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of transferrin receptor 1 as a hepatitis C virus entry factor

(2013) D. N. Martin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Screening of small molecules affecting mammalian P-body assembly uncovers links with diverse intracellular processes and organelle physiology

(2013) Javier P Martínez et al.   RNA Biology

Gain-of-Function Research: Unknown Risks

(2013) F. Rey et al.   SCIENCE

Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN

(2013) Kabamba B. Alexandre et al.   VIROLOGY

Correlation of Naturally Occurring HIV-1 Resistance to DEB025 with Capsid Amino Acid Polymorphisms

(2013) Philippe Gallay et al.   Viruses-Basel

Cyclophilin A: a key player for human disease

(2013) P Nigro et al.   Cell Death & Disease

The Lipid Kinase Phosphatidylinositol-4 Kinase III Alpha Regulates the Phosphorylation Status of Hepatitis C Virus NS5A

(2013) Simon Reiss et al.   PLoS Pathogens

Multiple Mutations in Hepatitis C Virus NS5A Domain II Are Required To Confer a Significant Level of Resistance to Alisporivir

(2012) Jose A. Garcia-Rivera et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dose- and schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial

(2012) Satoru Watanabe et al.   ANTIVIRAL RESEARCH

Griffithsin inhibits Japanese encephalitis virus infection in vitro and in vivo

(2012) Hassan Z. A. Ishag et al.   ARCHIVES OF VIROLOGY

The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication

(2012) Leen Delang et al.   BIOCHEMICAL PHARMACOLOGY

Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication

(2012) Hilde M van der Schaar et al.   CELL RESEARCH

Total Synthesis of a Noricumazole A Library and Evaluation of HCV Inhibition

(2012) Jenny Barbier et al.   CHEMISTRY-A EUROPEAN JOURNAL

Revisiting the Predictors of a Sustained Virologic Response in the Era of Direct-Acting Antiviral Therapy for Hepatitis C Virus

(2012) S. Beinhardt et al.   CLINICAL INFECTIOUS DISEASES

Cyclophilin Inhibitors for Hepatitis C Therapy

(2012) Fernando E. Membreno et al.   Clinics in Liver Disease

OC-025 Alisporivir inhibition of cellular cyclophilins disrupts hepatitis B virus (HBV) replication and this effect is further enhanced in combination with direct antiviral targeting HBV-DNA polymerase in vitro

(2012) S Chokshi et al.   GUT

Cyclophilin A is required for efficient human cytomegalovirus DNA replication and reactivation

(2012) L. R. Keyes et al.   JOURNAL OF GENERAL VIROLOGY

Host-targeting agents for prevention and treatment of chronic hepatitis C – Perspectives and challenges

(2012) Mirjam B. Zeisel et al.   JOURNAL OF HEPATOLOGY

Persistent hepatitis C virus (HCV) infection impairs HCV-specific cytotoxic T cell reactivity through Mcl-1/Bim imbalance due to CD127 down-regulation

(2012) J. R. Larrubia et al.   JOURNAL OF VIRAL HEPATITIS

Dissecting the Role of COPI Complexes in Influenza Virus Infection

(2012) E. Sun et al.   JOURNAL OF VIROLOGY

Cyclophilins Facilitate Dissociation of the Human Papillomavirus Type 16 Capsid Protein L1 from the L2/DNA Complex following Virus Entry

(2012) Malgorzata Bienkowska-Haba et al.   JOURNAL OF VIROLOGY

Myxobacteria: natural pharmaceutical factories

(2012) Juana Diez et al.   Microbial Cell Factories

Intrinsic antiviral immunity

(2012) Nan Yan et al.   NATURE IMMUNOLOGY

Modulating immunity as a therapy for bacterial infections

(2012) Robert E. W. Hancock et al.   NATURE REVIEWS MICROBIOLOGY

Viroporins: structure and biological functions

(2012) José Luis Nieva et al.   NATURE REVIEWS MICROBIOLOGY

Preliminary Study of Two Antiviral Agents for Hepatitis C Genotype 1

(2012) Anna S. Lok et al.   NEW ENGLAND JOURNAL OF MEDICINE

HIV–HBV Coinfection — A Global Challenge

(2012) Athena P. Kourtis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiviral activity of punicalagin toward human enterovirus 71 in vitro and in vivo

(2012) Yajun Yang et al.   PHYTOMEDICINE

Cyclosporin A Inhibits the Influenza Virus Replication through Cyclophilin A-Dependent and -Independent Pathways

(2012) Xiaoling Liu et al.   PLoS One

The Effects of Simvastatin or Interferon-α on Infectivity of Human Norovirus Using a Gnotobiotic Pig Model for the Study of Antivirals

(2012) Kwonil Jung et al.   PLoS One

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

The yin and yang of viruses and interferons

(2012) Ben X. Wang et al.   TRENDS IN IMMUNOLOGY

Hepatitis B virus and hepatitis C virus co-infection: A therapeutic challenge

(2012) Lamine Hamzaoui et al.   Clinics and Research in Hepatology and Gastroenterology

Virus–host interactomes — antiviral drug discovery

(2012) Yue Ma-Lauer et al.   Current Opinion in Virology

New horizons for antiviral drug discovery from virus–host protein interaction networks

(2012) Benoît de Chassey et al.   Current Opinion in Virology

Isolation and Total Synthesis of Icumazoles and Noricumazoles-Antifungal Antibiotics and Cation-Channel Blockers from Sorangium cellulosum

(2011) Jenny Barbier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Griffithsin Has Antiviral Activity against Hepatitis C Virus

(2011) Philip Meuleman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model

(2011) Abhay P.S. Rathore et al.   ANTIVIRAL RESEARCH

Natural products as catalysts for innovation: a pharmaceutical industry perspective

(2011) Esther K Schmitt et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites

(2011) Jun Sasaki et al.   EMBO JOURNAL

Glycosaminoglycans mediate retention of the poxvirus type I interferon binding protein at the cell surface to locally block interferon antiviral responses

(2011) Imma Montanuy et al.   FASEB JOURNAL

Statins Reduce Dengue Virus Production via Decreased Virion Assembly

(2011) Marlén Martínez-Gutierrez et al.   INTERVIROLOGY

Effect of accompanying antiretroviral drugs on virological response to pegylated interferon and ribavirin in patients co-infected with HIV and hepatitis C virus

(2011) J. Berenguer et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Cyclosporin A inhibits the replication of diverse coronaviruses

(2011) A. H. de Wilde et al.   JOURNAL OF GENERAL VIROLOGY

Residues in domain III of the dengue virus envelope glycoprotein involved in cell-surface glycosaminoglycan binding

(2011) D. Watterson et al.   JOURNAL OF GENERAL VIROLOGY

Genetic Inactivation of COPI Coatomer Separately Inhibits Vesicular Stomatitis Virus Entry and Gene Expression

(2011) D. K. Cureton et al.   JOURNAL OF VIROLOGY

Hydrolyzable Tannins (Chebulagic Acid and Punicalagin) Target Viral Glycoprotein-Glycosaminoglycan Interactions To Inhibit Herpes Simplex Virus 1 Entry and Cell-to-Cell Spread

(2011) L.-T. Lin et al.   JOURNAL OF VIROLOGY

Targeting of Toll-like receptors: a decade of progress in combating infectious diseases

(2011) Mona Hedayat et al.   LANCET INFECTIOUS DISEASES

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

Live-cell visualization of dynamics of HIV budding site interactions with an ESCRT component

(2011) Viola Baumgärtel et al.   NATURE CELL BIOLOGY

Integration of Antiretroviral Therapy with Tuberculosis Treatment

(2011) Salim S. Abdool Karim et al.   NEW ENGLAND JOURNAL OF MEDICINE

Boceprevir for Previously Treated Chronic HCV Genotype 1 Infection

(2011) Bruce R. Bacon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Earlier versus Later Start of Antiretroviral Therapy in HIV-Infected Adults with Tuberculosis

(2011) François-Xavier Blanc et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transporter-mediated drug–drug interactions

(2011) Fabian Müller et al.   PHARMACOGENOMICS

Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential

(2011) M. Zasloff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The host interactome of influenza virus presents new potential targets for antiviral drugs

(2011) Megan L. Shaw   REVIEWS IN MEDICAL VIROLOGY

Multifaceted roles for lipids in viral infection

(2011) Nicholas S. Heaton et al.   TRENDS IN MICROBIOLOGY

Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C

(2011) Geoffrey Férir et al.   VIROLOGY

Old World Arenaviruses Enter the Host Cell via the Multivesicular Body and Depend on the Endosomal Sorting Complex Required for Transport

(2011) Giulia Pasqual et al.   PLoS Pathogens

Glycosaminoglycans and Sialylated Glycans Sequentially Facilitate Merkel Cell Polyomavirus Infectious Entry

(2011) Rachel M. Schowalter et al.   PLoS Pathogens

The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

(2011) Susanne Pfefferle et al.   PLoS Pathogens

HIV/HCV Co-infection: Pathogenesis, Clinical Complications, Treatment, and New Therapeutic Technologies

(2011) Eva A. Operskalski et al.   Current HIV/AIDS Reports

Important Drug-Drug Interactions in HIV-Infected Persons on Antiretroviral Therapy: An Update on New Interactions Between HIV and Non-HIV Drugs

(2011) Alice Tseng et al.   Current Infectious Disease Reports

Antiviral activity of recombinant cyanovirin-N against HSV-1

(2011) Hong Yu et al.   VIROLOGICA SINICA

Labyrinthopeptins: A New Class of Carbacyclic Lantibiotics

(2010) Kathrin Meindl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibitors of Endoplasmic Reticulum α-Glucosidases Potently Suppress Hepatitis C Virus Virion Assembly and Release

(2010) Xiaowang Qu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Simvastatin potentiates the anti-hepatitis B virus activity of FDA-approved nucleoside analogue inhibitors in vitro

(2010) Ted Bader et al.   ANTIVIRAL RESEARCH

Marine compounds and their antiviral activities

(2010) Jarred Yasuhara-Bell et al.   ANTIVIRAL RESEARCH

Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity

(2010) Juliane Gentzsch et al.   ANTIVIRAL RESEARCH

Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays

(2010) Kyoji Hagiwara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Host-cell lipid rafts: a safe door for micro-organisms?

(2010) Flávia Sarmento Vieira et al.   BIOLOGY OF THE CELL

Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication

(2010) Nai-Yun Hsu et al.   CELL

Cytoplasmic Viral Replication Complexes

(2010) Johan A. den Boon et al.   Cell Host & Microbe

Imiquimod-induced clearance of HPV is associated with normalization of immune cell counts in usual type vulvar intraepithelial neoplasia

(2010) Annelinde Terlou et al.   INTERNATIONAL JOURNAL OF CANCER

Human MxA Protein: An Interferon-Induced Dynamin-Like GTPase with Broad Antiviral Activity

(2010) Otto Haller et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates

(2010) Lachlan R. Gray et al.   JOURNAL OF NEUROVIROLOGY

Viral Serine/Threonine Protein Kinases

(2010) T. Jacob et al.   JOURNAL OF VIROLOGY

Exploiting Drug Repositioning for Discovery of a Novel HIV Combination Therapy

(2010) C. L. Clouser et al.   JOURNAL OF VIROLOGY

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

(2010)   LANCET

Antiviral Lead Compounds from Marine Sponges

(2010) Sunil Sagar et al.   Marine Drugs

Natural product mode of action (MOA) studies: a link between natural and synthetic worlds

(2010) James J. La Clair   NATURAL PRODUCT REPORTS

Synthesis and biological activity of naturally occurring α-glucosidase inhibitors

(2010) Duncan J. Wardrop et al.   NATURAL PRODUCT REPORTS

Myxobacterial secondary metabolites: bioactivities and modes-of-action

(2010) Kira J. Weissman et al.   NATURAL PRODUCT REPORTS

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis

(2010) N. S. Heaton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIGorous Detection: Exposing Virus Through RNA Sensing

(2010) J. Rehwinkel et al.   SCIENCE

Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity

(2010) Tinoush Moulaei et al.   STRUCTURE

Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases

(2010) Tara L. Davis et al.   PLOS BIOLOGY

Structures of Triacetyloleandomycin and Mycalamide A Bind to the Large Ribosomal Subunit of Haloarcula marismortui

(2009) G. Gurel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections

(2009) Yousuke Furuta et al.   ANTIVIRAL RESEARCH

The ESCRT machinery: new functions in viral and cellular biology

(2009) Jeremy G. Carlton et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Host proteins involved in HIV infection: New therapeutic targets

(2009) Nathalie Arhel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The path to a successful vaccine adjuvant – ‘The long and winding road’

(2009) Derek T. O’Hagan et al.   DRUG DISCOVERY TODAY

No strings attached: the ESCRT machinery in viral budding and cytokinesis

(2009) B. McDonald et al.   JOURNAL OF CELL SCIENCE

Novel Chemical Space Exploration via Natural Products

(2009) Josefin Rosén et al.   JOURNAL OF MEDICINAL CHEMISTRY

Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

(2009) B. R. O'Keefe et al.   JOURNAL OF VIROLOGY

GBF1, a Guanine Nucleotide Exchange Factor for Arf, Is Crucial for Coxsackievirus B3 RNA Replication

(2009) K. H. W. Lanke et al.   JOURNAL OF VIROLOGY

Discovery of insect and human dengue virus host factors

(2009) October M. Sessions et al.   NATURE

Human host factors required for influenza virus replication

(2009) Renate König et al.   NATURE

Subcellular targeting strategies for drug design and delivery

(2009) Lawrence Rajendran et al.   NATURE REVIEWS DRUG DISCOVERY

Translation and replication of hepatitis C virus genomic RNA depends on ancient cellular proteins that control mRNA fates

(2009) N. Scheller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N

(2008) D SMEE et al.   ANTIVIRAL RESEARCH

Genome-Scale RNAi Screen for Host Factors Required for HIV Replication

(2008) Honglin Zhou et al.   Cell Host & Microbe

Statin-induced inhibition of HIV-1 release from latently infected U1 cells reveals a critical role for protein prenylation in HIV-1 replication

(2008) Tohti Amet et al.   MICROBES AND INFECTION

Antimicrobial and Antiviral Activity of Hydrolysable Tannins

(2008) Pietro Buzzini et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

GGA and Arf Proteins Modulate Retrovirus Assembly and Release

(2008) Anjali Joshi et al.   MOLECULAR CELL

Natural products to drugs: natural product-derived compounds in clinical trials

(2008) Mark S. Butler   NATURAL PRODUCT REPORTS

Global trends in emerging infectious diseases

(2008) Kate E. Jones et al.   NATURE

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE

Mouse Hepatitis Coronavirus RNA Replication Depends on GBF1-Mediated ARF1 Activation

(2008) Monique H. Verheije et al.   PLoS Pathogens