Persistent hepatitis C virus (HCV) infection impairs HCV-specific cytotoxic T cell reactivity through Mcl-1/Bim imbalance due to CD127 down-regulation

The Anti-Apoptotic Bcl-2 Family Member Mcl-1 Promotes T Lymphocyte Survival at Multiple Stages

(2014) I. Dzhagalov et al.   JOURNAL OF IMMUNOLOGY

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

(2011) Marc Pellegrini et al.   CELL

Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1+/CD127− HCV-specific CD8+ cells targeting the virus in chronic hepatitis C virus infection

(2011) Juan R. Larrubia et al.   CELLULAR IMMUNOLOGY

Prevention of cytokine withdrawal-induced apoptosis by Mcl-1 requires interaction between Mcl-1 and Bim

(2010) Sarwat Jamil et al.   Biochemistry and Cell Biology

Mechanisms of T Cell Death in the Liver: To Bim or Not to Bim?

(2010) Lauren E. Holz et al.   DIGESTIVE DISEASES

Sporadic Reappearance of Minute Amounts of Hepatitis C Virus RNA After Successful Therapy Stimulates Cellular Immune Responses

(2010) Naga Suresh Veerapu et al.   GASTROENTEROLOGY

Interleukin-7 promotes the survival of human CD4+effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway

(2010) Nizar Chetoui et al.   IMMUNOLOGY

PD-1 expression on peripheral CD8+ TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients

(2010) Tao Shen et al.   Virology Journal

Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+ T Cells Is Linked to Antigen Recognition and T Cell Differentiation

(2010) Bertram Bengsch et al.   PLoS Pathogens

HCV-related burden of disease in Europe: a systematic assessment of incidence, prevalence, morbidity, and mortality

(2009) Nikolai Mühlberger et al.   BMC PUBLIC HEALTH

Cell-Intrinsic Transforming Growth Factor-β Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence In Vivo

(2009) Roberto Tinoco et al.   IMMUNITY

Critical role for BIM in T cell receptor restimulation-induced death

(2008) Andrew L Snow et al.   Biology Direct

Intrahepatic Murine CD8 T-Cell Activation Associates With a Distinct Phenotype Leading to Bim-Dependent Death

(2008) Lauren E. Holz et al.   GASTROENTEROLOGY

Impaired Hepatitis C Virus (HCV)-Specific Effector CD8+ T Cells Undergo Massive Apoptosis in the Peripheral Blood during Acute HCV Infection and in the Liver during the Chronic Phase of Infection

(2008) H. Radziewicz et al.   JOURNAL OF VIROLOGY