Synthesis, Structure-Activity, and Structure-Stability Relationships of 2-Substituted-N-(4-oxo-3-oxetanyl)N-Acylethanolamine Acid Amidase (NAAA) Inhibitors

Synthesis and Structure–Activity Relationship (SAR) of 2-Methyl-4-oxo-3-oxetanylcarbamic Acid Esters, a Class of Potent N-Acylethanolamine Acid Amidase (NAAA) Inhibitors

(2013) Stefano Ponzano et al.   JOURNAL OF MEDICINAL CHEMISTRY

A fatty gut feeling

(2013) Daniele Piomelli   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase

(2012) Yumiko Yamano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis and Structure–Activity and Structure–Property Relationships

(2012) Andrea Duranti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peroxisome Proliferator-Activated Receptor   Mediates Acute Effects of Palmitoylethanolamide on Sensory Neurons

(2012) I. A. Khasabova et al.   JOURNAL OF NEUROSCIENCE

N-acylethanolamine acid amidase (NAAA), a new path to unleash PPAR-mediated analgesia

(2012) Bradley K. Taylor   PAIN

Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models

(2012) Oscar Sasso et al.   PAIN

Design and Synthesis of Potent N-Acylethanolamine-hydrolyzing Acid Amidase (NAAA) Inhibitor as Anti-Inflammatory Compounds

(2012) Yuhang Li et al.   PLoS One

Biochemical and Mass Spectrometric Characterization of Human N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibition

(2012) Jay M. West et al.   PLoS One

β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine

(2012) Andrea Armirotti et al.   ACS Medicinal Chemistry Letters

Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series

(2012) Jan Keppel Hesselink et al.   Journal of Pain Research

Mass Spectrometric Characterization of Human N-Acylethanolamine-hydrolyzing Acid Amidase

(2011) Jay M. West et al.   JOURNAL OF PROTEOME RESEARCH

Acylating drugs: redesigning natural covalent inhibitors

(2010) Arthur F Kluge et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Synthesis and Structure−Activity Relationships ofN-(2-Oxo-3-oxetanyl)amides asN-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors

(2010) Carlos Solorzano et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA)

(2010) Natsuo Ueda et al.   PROGRESS IN LIPID RESEARCH

Protective role of palmitoylethanolamide in contact allergic dermatitis

(2009) S. Petrosino et al.   ALLERGY

Synthesis and biological evaluation of new potential inhibitors of N-acylethanolamine hydrolyzing acid amidase

(2009) Carmela Saturnino et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation

(2009) C. Solorzano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A simple and efficient method for the synthesis of Erlenmeyer azlactones

(2009) Philip A. Conway et al.   TETRAHEDRON

β-Lactones as Privileged Structures for the Active-Site Labeling of Versatile Bacterial Enzyme Classes

(2008) Thomas Böttcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amino acid residues crucial in pH regulation and proteolytic activation of N-acylethanolamine-hydrolyzing acid amidase

(2008) Jun Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Fluoroalkyl substituted (Z)-dehydro α-amino ester as a building block for the fluorine-containing cyclopropyl α-amino esters and dihydrooxazole

(2008) Wen Wan et al.   JOURNAL OF FLUORINE CHEMISTRY

β-Lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana

(2008) Zheming Wang et al.   Nature Chemical Biology