Mast cells, glia and neuroinflammation: partners in crime?

The role of mast cells in neuroinflammation

(2013) Sofie Nelissen et al.   ACTA NEUROPATHOLOGICA

Mast Cell Tryptase Induces Microglia Activation via Protease-activated Receptor 2 Signaling

(2013) Shu Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Amyotrophic Lateral Sclerosis Treatment with Ultramicronized Palmitoylethanolamide: A Case Report

(2013) Simonetta Clemente   CNS & Neurological Disorders-Drug Targets

Palmitoylethanolamide Reduces Formalin-Induced Neuropathic-Like Behaviour Through Spinal Glial/Microglial Phenotypical Changes in Mice

(2013) Livio Luongo et al.   CNS & Neurological Disorders-Drug Targets

Metabolism of endocannabinoids and relatedN-acylethanolamines: Canonical and alternative pathways

(2013) Natsuo Ueda et al.   FEBS Journal

Neuroinflammation and psychiatric illness

(2013) Souhel Najjar et al.   Journal of Neuroinflammation

Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism

(2013) L. Di Cesare Mannelli et al.   MEDIATORS OF INFLAMMATION

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

Palmitoylethanolamide and stearoylethanolamide levels in the interstitium of the trapezius muscle of women with chronic widespread pain and chronic neck-shoulder pain correlate with pain intensity and sensitivity

(2013) Nazdar Ghafouri et al.   PAIN

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology

(2013) J.-P. Michaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

(2013) I. Tabas et al.   SCIENCE

Mast cells on the mind: new insights and opportunities

(2013) Rae Silver et al.   TRENDS IN NEUROSCIENCES

Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase

(2012) Yumiko Yamano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Administration of palmitoylethanolamide (PEA) protects the neurovascular unit and reduces secondary injury after traumatic brain injury in mice

(2012) Akbar Ahmad et al.   BRAIN BEHAVIOR AND IMMUNITY

Reduction of ischemic brain injury by administration of palmitoylethanolamide after transient middle cerebral artery occlusion in rats

(2012) Akbar Ahmad et al.   BRAIN RESEARCH

Palmitoylethanolamide Restores Myelinated-Fibre Function in Patients with Chemotherapy-Induced Painful Neuropathy

(2012) A. Truini et al.   CNS & Neurological Disorders-Drug Targets

Roles of Chemokine CXCL12 and its Receptors in Ischemic Stroke

(2012) Yongting Wang et al.   CURRENT DRUG TARGETS

Serotonin of mast cell origin contributes to hippocampal function

(2012) Katherine M. Nautiyal et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Microglia and mast cells: two tracks on the road to neuroinflammation

(2012) Stephen D. Skaper et al.   FASEB JOURNAL

Microglia and neurodegeneration: The role of systemic inflammation

(2012) Colm Cunningham   GLIA

Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α

(2012) Caterina Scuderi et al.   Journal of Neuroinflammation

Neuroprotective function for ramified microglia in hippocampal excitotoxicity

(2012) Jonathan Vinet et al.   Journal of Neuroinflammation

Oxidative Stress and Microglial Cells in Parkinson's Disease

(2012) Lynda J. Peterson et al.   MEDIATORS OF INFLAMMATION

Peripheral nerve inflammation in ALS mice: cause or consequence

(2012) O. Kano et al.   NEUROLOGY

Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy

(2012) Rita Citraro et al.   NEUROPHARMACOLOGY

Resident glial cell activation in response to perispinal inflammation leads to acute changes in nociceptive sensitivity: Implications for the generation of neuropathic pain

(2012) Gustavo Tenorio et al.   PAIN

Mast cell-glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide

(2012) S. D. Skaper et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Neuroprotective Activities of Palmitoylethanolamide in an Animal Model of Parkinson's Disease

(2012) Emanuela Esposito et al.   PLoS One

Multimodal stepped care approach with acupuncture and PPAR-α agonist palmitoylethanolamide in the treatment of a patient with multiple sclerosis and central neuropathic pain

(2012) David J Kopsky et al.   Acupuncture in Medicine

Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury

(2011) Emanuela Esposito et al.   BRAIN BEHAVIOR AND IMMUNITY

Acute amygdaloid response to systemic inflammation

(2011) Harald Engler et al.   BRAIN BEHAVIOR AND IMMUNITY

Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity

(2011) Dan Levy et al.   BRAIN BEHAVIOR AND IMMUNITY

Amyotrophic lateral sclerosis: A neurovascular disease

(2011) Svitlana Garbuzova-Davis et al.   BRAIN RESEARCH

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors within vivoefficacy in a pain model

(2011) E Ballini et al.   BRITISH JOURNAL OF PHARMACOLOGY

CCL5 induces a pro-inflammatory profile in microglia in vitro

(2011) Jelena Škuljec et al.   CELLULAR IMMUNOLOGY

Evidence that Microglia Mediate the Neurobiological Effects of Chronic Psychological Stress on the Medial Prefrontal Cortex

(2011) M. Hinwood et al.   CEREBRAL CORTEX

Visceral Pain: Spinal Afferents, Enteric Mast Cells, Enteric Nervous System and Stress

(2011) Jackie D. Wood   CURRENT PHARMACEUTICAL DESIGN

Mast cells promote Th1 and Th17 responses by modulating dendritic cell maturation and function

(2011) Anne Dudeck et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity

(2011) Vito de Novellis et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification of a microglia phenotype supportive of remyelination

(2011) Marta Olah et al.   GLIA

Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide

(2011) Caterina Scuderi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

(2011) S. Liu et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Enhance Mast Cell Production of IL-6 via Surface-Bound TGF- 

(2011) K. Ganeshan et al.   JOURNAL OF IMMUNOLOGY

Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L

(2011) Dae Kim et al.   Journal of Neuroinflammation

TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

(2011) Min Song et al.   Journal of Neuroinflammation

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

(2011) Thomas Philips et al.   LANCET NEUROLOGY

Surface TLR2 and TLR4 Expression on Mature Rat Mast Cells Can Be Affected by Some Bacterial Components and Proinflammatory Cytokines

(2011) Anna Pietrzak et al.   MEDIATORS OF INFLAMMATION

Central Nervous System Mast Cells in Peripheral Inflammatory Nociception

(2011) Dimitris N Xanthos et al.   Molecular Pain

Palmitoylethanolamide Reduces Granuloma-Induced Hyperalgesia by Modulation of Mast Cell Activation in Rats

(2011) Daniele De Filippis et al.   Molecular Pain

Proinflammatory Stimuli Control N-Acylphosphatidylethanolamine-Specific Phospholipase D Expression in Macrophages

(2011) C. Zhu et al.   MOLECULAR PHARMACOLOGY

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue

(2011) M. Casula et al.   NEUROSCIENCE

A new definition of neuropathic pain

(2011) Troels S. Jensen et al.   PAIN

Mast Cell Accumulation in Glioblastoma with a Potential Role for Stem Cell Factor and Chemokine CXCL12

(2011) Jelena Põlajeva et al.   PLoS One

Purinergic signalling: From normal behaviour to pathological brain function

(2011) Geoffrey Burnstock et al.   PROGRESS IN NEUROBIOLOGY

Cerebral Mast Cells Mediate Blood-Brain Barrier Disruption in Acute Experimental Ischemic Stroke Through Perivascular Gelatinase Activation

(2011) Olli S. Mattila et al.   STROKE

MAST CELLS IN PLAQUES OF MULTIPLE SCLEROSIS

(2010) Yngve Olsson   ACTA NEUROLOGICA SCANDINAVICA

A granular variant of CD63 is a regulator of repeated human mast cell degranulation

(2010) T. Schäfer et al.   ALLERGY

Mast cell activation and autism

(2010) Theoharis C. Theoharides et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Upregulation of Toll-like Receptor (TLR) Expression and Release of Cytokines from Mast Cells by IL-12

(2010) Haiwei Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

TNF Increases Expression of IL-4 and PARs in Mast Cells

(2010) Huiyun Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Induction of IL-13 production and upregulation of gene expression of protease activated receptors in P815 cells by IL-6

(2010) Huiyun Zhang et al.   CYTOKINE

Interleukin-15 and Interleukin-12 Are Elevated in Serum and Cerebrospinal Fluid of Patients with Amyotrophic Lateral Sclerosis

(2010) Michael Rentzos et al.   EUROPEAN NEUROLOGY

Mast Cells as Early Responders in the Regulation of Acute Blood–Brain Barrier Changes after Cerebral Ischemia and Hemorrhage

(2010) Perttu Johannes Lindsberg et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Meningeal Mast Cells Affect Early T Cell Central Nervous System Infiltration and Blood-Brain Barrier Integrity through TNF: A Role for Neutrophil Recruitment?

(2010) B. A. Sayed et al.   JOURNAL OF IMMUNOLOGY

Synthesis and Structure−Activity Relationships ofN-(2-Oxo-3-oxetanyl)amides asN-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors

(2010) Carlos Solorzano et al.   JOURNAL OF MEDICINAL CHEMISTRY

IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients

(2010) Milan Fiala et al.   Journal of Neuroinflammation

The viral TLR3 agonist poly(I:C) stimulates phagocytosis and intracellular killing of Escherichia coli by microglial cells

(2010) Sandra Ribes et al.   NEUROSCIENCE LETTERS

Glial Cells and Chronic Pain

(2010) Romain-Daniel Gosselin et al.   NEUROSCIENTIST

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

Chronic stress induces transient spinal neuroinflammation, triggering sensory hypersensitivity and long-lasting anxiety-induced hyperalgesia

(2010) Cyril Rivat et al.   PAIN

Chemokines, neuronal–glial interactions, and central processing of neuropathic pain

(2010) Yong-Jing Gao et al.   PHARMACOLOGY & THERAPEUTICS

Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-κB nuclear signalling in dorsal root ganglia

(2009) Giuseppe D'Agostino et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Human mast cells synthesize and release angiogenin, a member of the ribonuclease A (RNase A) superfamily

(2009) Marianna Kulka et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mast cell adhesion induces cytoskeletal modifications and programmed cell death in oligodendrocytes

(2009) Nevenka Medic et al.   JOURNAL OF NEUROIMMUNOLOGY

P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation

(2009) T. Trang et al.   JOURNAL OF NEUROSCIENCE

Behavioral Phenotypes of Mice Lacking Purinergic P2X4 Receptors in Acute and Chronic Pain Assays

(2009) Makoto Tsuda et al.   Molecular Pain

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

(2009) Stefan A Grathwohl et al.   NATURE NEUROSCIENCE

Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation

(2009) C. Solorzano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mast Cells Are Early Responders After Hypoxia-Ischemia in Immature Rat Brain

(2009) Yuxuan Jin et al.   STROKE

Mast cell activation is characterized by upregulation of a functional anaphylatoxin C5a receptor

(2008) Afsaneh Soruri et al.   BMC IMMUNOLOGY

Systemic Glucocorticoid Therapy Reduces Pain and the Number of Endoneurial Tumor Necrosis Factor-Alpha (TNFα)-Positive Mast Cells in Rats With a Painful Peripheral Neuropathy

(2008) Reiko Hayashi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Effects of Palmitoylethanolamide on Signaling Pathways Implicated in the Development of Spinal Cord Injury

(2008) T. Genovese et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inhibition of fatty acid amide hydrolase and cyclooxygenase-2 increases levels of endocannabinoid related molecules and produces analgesia via peroxisome proliferator-activated receptor-alpha in a model of inflammatory pain

(2008) Maulik D. Jhaveri et al.   NEUROPHARMACOLOGY

The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors

(2008) Barbara Costa et al.   PAIN

Brain mast cells link the immune system to anxiety-like behavior

(2008) K. M. Nautiyal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia produce and hydrolyze palmitoylethanolamide

(2007) Giulio G. Muccioli et al.   NEUROPHARMACOLOGY