Metabolism of endocannabinoids and relatedN-acylethanolamines: Canonical and alternative pathways

Biosynthetic Pathways of Bioactive N-Acylethanolamines in Brain

(2013) Kazuhito Tsuboi et al.   CNS & Neurological Disorders-Drug Targets

ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC

(2013) Jacqueline L. Blankman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous Molecules Stimulating N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA)

(2012) Tatsuya Tai et al.   ACS Chemical Neuroscience

A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance

(2012) Craig D. Simpson et al.   APOPTOSIS

N-acylation of phosphatidylethanolamine and its biological functions in mammals

(2012) Niels Wellner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase

(2012) Yumiko Yamano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Monoacylglycerol lipase - a target for drug development?

(2012) CJ Fowler   BRITISH JOURNAL OF PHARMACOLOGY

Discrimination between Two Endocannabinoids

(2012) Natsuo Ueda et al.   CHEMISTRY & BIOLOGY

Highly Selective Inhibitors of Monoacylglycerol Lipase Bearing a Reactive Group that Is Bioisosteric with Endocannabinoid Substrates

(2012) Jae Won Chang et al.   CHEMISTRY & BIOLOGY

Visualization by mass spectrometry of 2-dimensional changes in rat brain lipids, including N-acylphosphatidylethanolamines, during neonatal brain ischemia

(2012) Christian Janfelt et al.   FASEB JOURNAL

Generation ofN-Acylphosphatidylethanolamine by Members of the Phospholipase A/Acyltransferase (PLA/AT) Family

(2012) Toru Uyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure/Function Relationships of Adipose Phospholipase A2Containing a Cys-His-His Catalytic Triad

(2012) Xiao-Yan Pang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the Acyltransferase Activity of Lecithin:Retinol Acyltransferase-like Proteins

(2012) Marcin Golczak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)

(2012) Dina Navia-Paldanius et al.   JOURNAL OF LIPID RESEARCH

N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis and Structure–Activity and Structure–Property Relationships

(2012) Andrea Duranti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of Potent N-Acylethanolamine-hydrolyzing Acid Amidase (NAAA) Inhibitor as Anti-Inflammatory Compounds

(2012) Yuhang Li et al.   PLoS One

Biochemical and Mass Spectrometric Characterization of Human N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibition

(2012) Jay M. West et al.   PLoS One

Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression

(2012) Asami Tanimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine

(2012) Andrea Armirotti et al.   ACS Medicinal Chemistry Letters

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors

(2011) J. R. Savinainen et al.   Acta Physiologica

Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice

(2011) Niels Wellner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways

(2011) Kazuhito Tsuboi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Occurrence, biosynthesis and functions of N-acylphosphatidylethanolamines (NAPE): Not just precursors of N-acylethanolamines (NAE)

(2011) Denis Coulon et al.   BIOCHIMIE

Dual Inhibition of α/β-Hydrolase Domain 6 and Fatty Acid Amide Hydrolase Increases Endocannabinoid Levels in Neurons

(2011) William R. Marrs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance

(2011) Ulrike Taschler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Peroxisomal Lipid Metabolism by Catalytic Activity of Tumor Suppressor H-rev107

(2011) Toru Uyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans

(2011) Katrine B. Hansen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes

(2011) Naoki Shinohara et al.   JOURNAL OF LIPID RESEARCH

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

(2011) K. Ahn et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mass Spectrometric Characterization of Human N-Acylethanolamine-hydrolyzing Acid Amidase

(2011) Jay M. West et al.   JOURNAL OF PROTEOME RESEARCH

Proinflammatory Stimuli Control N-Acylphosphatidylethanolamine-Specific Phospholipase D Expression in Macrophages

(2011) C. Zhu et al.   MOLECULAR PHARMACOLOGY

N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans

(2011) Mark Lucanic et al.   NATURE

(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2

(2011) Kelsey C Duggan et al.   Nature Chemical Biology

A catalytically silent FAAH-1 variant drives anandamide transport in neurons

(2011) Jin Fu et al.   NATURE NEUROSCIENCE

N-Acylethanolamines and related compounds: Aspects of metabolism and functions

(2011) Denis Coulon et al.   PLANT SCIENCE

Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver

(2011) B. Mukhopadhyay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Mutations in ABHD12 Cause the Neurodegenerative Disease PHARC: An Inborn Error of Endocannabinoid Metabolism

(2010) Torunn Fiskerstrand et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Enzymological studies on the biosynthesis of N-acylethanolamines

(2010) Natsuo Ueda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

N-palmitoyl-ethanolamine: Biochemistry and new therapeutic opportunities

(2010) Stefania Petrosino et al.   BIOCHIMIE

Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol

(2010) Natsuo Ueda et al.   BIOFACTORS

The Glycerophospho Metabolome and Its Influence on Amino Acid Homeostasis Revealed by Brain Metabolomics of GDE1(−/−) Mice

(2010) Florian Kopp et al.   CHEMISTRY & BIOLOGY

A Review on the Monoacylglycerol Lipase: At the Interface Between Fat and Endocannabinoid Signalling

(2010) G. Labar et al.   CURRENT MEDICINAL CHEMISTRY

Discovery and Development of Endocannabinoid-Hydrolyzing Enzyme Inhibitors

(2010) Anna Minkkila et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Solution structure of the N-terminal catalytic domain of human H-REV107 - A novel circular permutated NlpC/P60 domain

(2010) Xiaobai Ren et al.   FEBS LETTERS

Synthesis and Structure−Activity Relationships ofN-(2-Oxo-3-oxetanyl)amides asN-Acylethanolamine-hydrolyzing Acid Amidase Inhibitors

(2010) Carlos Solorzano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Diacylglycerol Lipase Is Not Involved in Depolarization-Induced Suppression of Inhibition at Unitary Inhibitory Connections in Mouse Hippocampus

(2010) R. Min et al.   JOURNAL OF NEUROSCIENCE

Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice

(2010) Y. Gao et al.   JOURNAL OF NEUROSCIENCE

Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo

(2010) Gabriel M. Simon et al.   Molecular BioSystems

Monoacylglycerol Lipase Activity Is a Critical Modulator of the Tone and Integrity of the Endocannabinoid System

(2010) P. K. Chanda et al.   MOLECULAR PHARMACOLOGY

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

(2010) William R Marrs et al.   NATURE NEUROSCIENCE

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

(2010) Joel E Schlosburg et al.   NATURE NEUROSCIENCE

The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase α Mediates Retrograde Suppression of Synaptic Transmission

(2010) Asami Tanimura et al.   NEURON

A Common Haplotype in NAPEPLD Is Associated With Severe Obesity in a Norwegian Population-Based Cohort (the HUNT Study)

(2010) Teresia Wangensteen et al.   Obesity

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA)

(2010) Natsuo Ueda et al.   PROGRESS IN LIPID RESEARCH

Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance

(2010) Kiyoko Fukami et al.   PROGRESS IN LIPID RESEARCH

N-acylethanolamines, anandamide and food intake

(2009) Harald S. Hansen et al.   BIOCHEMICAL PHARMACOLOGY

Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes

(2009) Toru Uyama et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Synthesis and biological evaluation of new potential inhibitors of N-acylethanolamine hydrolyzing acid amidase

(2009) Carmela Saturnino et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Crystal Structure of the Human Monoacylglycerol Lipase, a Key Actor in Endocannabinoid Signaling

(2009) Geoffray Labar et al.   CHEMBIOCHEM

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(2009) Kay Ahn et al.   CHEMISTRY & BIOLOGY

Synthesis and Pharmacological Activity of a Potent Inhibitor of the Biosynthesis of the Endocannabinoid 2-Arachidonoylglycerol

(2009) Tiziana Bisogno et al.   ChemMedChem

Lipid Droplets Are Novel Sites ofN-Acylethanolamine Inactivation by Fatty Acid Amide Hydrolase-2

(2009) Martin Kaczocha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Human Monoglyceride Lipase Inhibition

(2009) T. Bertrand et al.   JOURNAL OF MOLECULAR BIOLOGY

AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency

(2009) Kathy Jaworski et al.   NATURE MEDICINE

Endocannabinoid-Mediated Control of Synaptic Transmission

(2009) Masanobu Kano et al.   PHYSIOLOGICAL REVIEWS

Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation

(2009) C. Solorzano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo

(2009) J. Z. Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro synthesis of arachidonoyl amino acids by cytochrome c

(2009) Jeffrey M. McCue et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

cDNA cloning and characterization of human and mouse Ca2+-independent phosphatidylethanolamine N-acyltransferases

(2008) Xing-Hua Jin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling

(2008) Heather S. Hoover et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-acylphosphatidylethanolamine, a Gut- Derived Circulating Factor Induced by Fat Ingestion, Inhibits Food Intake

(2008) Matthew P. Gillum et al.   CELL

Expression and Secretion of N-acylethanolamine-hydrolysing Acid Amidase in Human Prostate Cancer Cells

(2008) J. Wang et al.   JOURNAL OF BIOCHEMISTRY

Non-redundant Functions of Cyclooxygenases: Oxygenation of Endocannabinoids

(2008) Carol A. Rouzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Functional Characterization of Adipose-specific Phospholipase A2(AdPLA)

(2008) Robin E. Duncan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoproteolytic Cleavage and Activation of Human Acid Ceramidase

(2008) Nataly Shtraizent et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anandamide Biosynthesis Catalyzed by the Phosphodiesterase GDE1 and Detection of Glycerophospho-N-acyl Ethanolamine Precursors in Mouse Brain

(2008) Gabriel M. Simon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HRASLS3 is a PPARγ-selective target gene that promotes adipocyte differentiation

(2008) Sarah Hummasti et al.   JOURNAL OF LIPID RESEARCH

The tumor suppressor gene H-Rev107 functions as a novel Ca2+-independent cytosolic phospholipase A1/2of the thiol hydrolase type

(2008) Toru Uyama et al.   JOURNAL OF LIPID RESEARCH

Activation of the endocannabinoid system by organophosphorus nerve agents

(2008) Daniel K Nomura et al.   Nature Chemical Biology

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

The contribution of cyclooxygenase-2 to endocannabinoid metabolism and action

(2007) C J Fowler   BRITISH JOURNAL OF PHARMACOLOGY

The stimulatory effect of phosphatidylethanolamine on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD)

(2007) Jun Wang et al.   NEUROPHARMACOLOGY

Multiple pathways involved in the biosynthesis of anandamide

(2007) Jie Liu et al.   NEUROPHARMACOLOGY

Phosphatidic Acid as the Biosynthetic Precursor of the Endocannabinoid 2-Arachidonoylglycerol in Intact Mouse Neuroblastoma Cells Stimulated with Ionomycin

(2003) Tiziana Bisogno et al.   JOURNAL OF NEUROCHEMISTRY