Article
Chemistry, Applied
Lidan Wu, Wenjie Jiang, Na Zhao, Fengshan Wang
Summary: Heparan sulfate (HS) shows promise as a therapeutic agent for Alzheimer's disease (AD) by promoting Aβ fibrosis, improving cognitive impairments, and reducing Aβ deposition in the brain.
CARBOHYDRATE POLYMERS
(2022)
Article
Clinical Neurology
Shang Wang, Taiyang Zhu, Wanyan Ni, Chao Zhou, Hui Zhou, Li Lin, Yuting Hu, Xiaoyu Sun, Jingjing Han, Yan Zhou, Guoliang Jin, Jie Zu, Hongjuan Shi, Xingxing Yang, Zuohui Zhang, Fang Hua
Summary: This study investigates the role of early activation of Toll-like receptor 3 (TLR3) in the pathophysiological process of Alzheimer's disease (AD). The results showed that the early activation of TLR3 attenuated neuronal loss and neurobehavioral dysfunction in a mouse model of AD. This could be attributed to its role in A beta clearance, the inhibition of glial cells, and the regulation of neuroinflammation in the hippocampus.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Neurosciences
Victoria Gomez-Murcia, Kevin Carvalho, Bryan Thiroux, Raphaelle Caillierez, Melanie Besegher, Nicolas Sergeant, Luc Buee, Emile Faivre, David Blum
Summary: Due to the complexity of Alzheimer's disease, it is of interest to find multitarget approaches that can mitigate multiple pathogenic mechanisms. In this study, the potential of Doxycycline (Dox), a second-generation tetracycline, in the APP/PS1 mouse model of amyloidogenesis was evaluated. The results showed that Dox moderately improved spatial memory in APP/PS1 mice without major effect on amyloid lesions. The study also found that Dox enhanced the amyloid-dependent upregulation of neuroinflammatory markers. Overall, chronic Dox delivery did not provide significant pathophysiological improvements in the APP/PS1 mouse model.
Article
Neurosciences
Henrique Correia Campos, Deidiane Elisa Ribeiro, Debora Hashiguchi, Talita Glaser, Milena da Silva Milanis, Christiane Gimenes, Deborah Suchecki, Ricardo Mario Arida, Henning Ulrich, Beatriz Monteiro Longo
Summary: The aim of this study was to investigate the effects of resistance exercise on preventing and recovering from AD-related neuropathological conditions in APP/PS1 mice. The results showed that 4 weeks of resistance exercise improved locomotor activity and memory in APP/PS1 mice, and reduced A beta plaques and systemic inflammation. These findings suggest that resistance exercise plays a role in alleviating AD symptoms and can be an effective complementary treatment for AD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Arnold M. Salazar, Amanda M. Leisgang, Andrew A. Ortiz, Andrew S. Murtishaw, Jefferson W. Kinney
Summary: The study demonstrates altered GABAergic signaling in an amyloid model of AD, with changes in GABA-related targets associated with disease-related memory and learning deficits.
NEUROBIOLOGY OF AGING
(2021)
Article
Biochemistry & Molecular Biology
Ih-Jen Su, Chia-Yu Hsu, Santai Shen, Po-Kuan Chao, John Tsu-An Hsu, Jung-Tsung Hsueh, Jia-Jun Liang, Ying-Ting Hsu, Feng-Shiun Shie
Summary: Research showed that a combination treatment (anti-Aβ antibody NP106 and curcumin analog TML-6) can more effectively lower Aβ levels, improve behavioral deficits, and normalize gut microbiota, providing a new avenue for developing more effective AD treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Nelda Antonovaite, Lianne A. Hulshof, Christiaan F. M. Huffels, Elly M. Hol, Wytse J. Wadman, Davide Iannuzzi
Summary: Evidence of altered tissue mechanics in neurodegeneration is increasing, especially in Alzheimer's disease. Viscoelastic differences have been found in the brain tissue of APP/PS1 mice compared to wild-type mice, with regions in the hippocampus showing increased stiffness and viscous dissipation. Despite overall mechanical heterogeneity, local alterations in stiffness were not observed at the cellular scale around the plaques.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Plant Sciences
Caixia Zang, Hui Liu, Junmei Shang, Hanyu Yang, Lu Wang, Chanjuan Sheng, Zihong Zhang, Xiuqi Bao, Yang Yu, Xinsheng Yao, Dan Zhang
Summary: The study demonstrates that GJ-4 improves cognitive deficits in APP/PS1 transgenic mice by reducing A beta levels, inhibiting tau protein phosphorylation, and suppressing neuroinflammatory responses. These findings provide a basis for further development of GJ-4 as a potential treatment for AD.
Article
Neurosciences
Rachel R. Corrigan, Luis Labrador, John Grizzanti, Megan Mey, Helen Piontkivska, Gemma Casadesus
Summary: The study aims to investigate the role of pancreatic amylin peptide in metabolic regulation and its relationship with Alzheimer's disease. The results show that amylin improves cognitive function, while inhibiting amylin receptors increases the risk of Alzheimer's disease. Additionally, there are different neuroprotective mechanisms in response to amylin therapy between females and males.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Pharmacology & Pharmacy
Ye Yuan, Yamei Liu, Li Hao, Jinlian Ma, Simai Shao, Ziyang Yu, Ming Shi, Zhenqiang Zhang, Zijuan Zhang
Summary: In this study, the mechanism of action of the Chinese medicine formula Liuwei Dihuang Pill (LWD) in treating Alzheimer's disease (AD) was investigated through network pharmacological analysis. The results showed that LWD exerts its therapeutic effects on AD through the inhibition of inflammatory response, regulation of neuronal state, and autophagy. Additionally, the study demonstrated the neuroprotective effect of LWD on APP/PS1 mice.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Jiawei Zhang, Yaling Zheng, Yao Zhao, Yaxuan Zhang, Yu Liu, Fang Ma, Xiuzhe Wang, Jianliang Fu
Summary: Andrographolide can significantly alleviate cognitive impairments, reduce amyloid-β deposition, inhibit microglial activation, and decrease the secretion of proinflammatory factors in APP/PS1 mice. Furthermore, transcriptome sequencing analysis revealed that Andro could significantly decrease the expression of various genes associated with inflammation in APP/PS1 mice, which was further validated by qRT-PCR. Our results suggest that Andro might be a potential therapeutic drug for AD by regulating neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Xiao-bo Yang, Heng-bing Zu, Yong-fei Zhao, Kai Yao
Summary: Agomelatine can improve cognitive impairment and ameliorate AD-like pathology in APP/PS1 mice by activating DHCR24 signaling and inhibiting Akt/mTOR and Hes1/Notch1 signaling pathways. It may become a promising drug candidate in the therapy of Alzheimer's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Liangyun Liu, Jianing Cao, Chujun Huang, Erdong Yuan, Jiaoyan Ren
Summary: Cognitive impairment is a major clinical feature in AD patients, but research suggests peripheral organs may also play a role in AD pathology. Studies on aged APP/PS1 mice show increased inflammation response and decreased anti-oxidative capacity in peripheral organs, highlighting the need for a more comprehensive approach to studying AD.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Nutrition & Dietetics
Yacoubou Abdoul Razak Mahaman, Jun Feng, Fang Huang, Maibouge Tanko Mahamane Salissou, Jianzhi Wang, Rong Liu, Bin Zhang, Honglian Li, Feiqi Zhu, Xiaochuan Wang
Summary: Alzheimer's disease is a global health problem with no effective single therapy. Nutraceutical agents like Moringa oleifera (MO), which have multiple effects, show promise in treating AD. This study found that MO treatment improved behavioral and cognitive deficits, reduced A beta burden, and improved synaptic plasticity and neurodegeneration in AD mice.
Article
Food Science & Technology
Yu-Shi Gong, Fang-Li Hou, Juan Guo, Lin Lin, Fu-Yong Zhu
Summary: The study found that high-dose alcohol intake impairs learning and memory abilities, increases A beta content and deposition, and promotes the progression of AD; while low-dose alcohol can mitigate excessive production of A beta and counteract the development of AD.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemical Research Methods
Mingrui An, Hongyan Shen, Jun Cao, Xiucong Pei, Yanxu Chang, Shuaipeng Ma, Jintao Bao, Xuefei Zhang, Xue Bai, Yuanhui Ma
ANALYTICAL BIOCHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Shuaipeng Ma, Xuefei Zhang, Liangjun Zheng, Zeyang Li, Xuyang Zhao, Wenjia Lai, Hongyan Shen, Junniao Lv, Guofeng Yang, Qingsong Wang, Jianguo Ji
ANTIOXIDANTS & REDOX SIGNALING
(2016)
Article
Biochemistry & Molecular Biology
Xuefei Zhang, Xiaoqing Ren, Qi Zhang, Zheyi Li, Shuaipeng Ma, Jintao Bao, Zeyang Li, Xue Bai, Liangjun Zheng, Zhong Zhang, Shujiang Shang, Chen Zhang, Chuangui Wang, Liu Cao, Qingsong Wang, Jianguo Ji
ANTIOXIDANTS & REDOX SIGNALING
(2016)
Article
Cell Biology
L. Tang, H. Shen, X. Li, Z. Li, Z. Liu, J. Xu, S. Ma, X. Zhao, X. Bai, M. Li, Q. Wang, J. Ji
CELL DEATH & DISEASE
(2016)
Article
Cell Biology
Jintao Bao, Liangjun Zheng, Qi Zhang, Xinya Li, Xuefei Zhang, Zeyang Li, Xue Bai, Zhong Zhang, Wei Huo, Xuyang Zhao, Shujiang Shang, Qingsong Wang, Chen Zhang, Jianguo Ji
Article
Biochemical Research Methods
Guoming Li, Linglong Qu, Shuaipeng Ma, Yujie Wu, Changwen Jin, Xiaofeng Zheng
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2014)
Article
Biophysics
Xiaogang Niu, Shuaipeng Ma, Yunfei Hu, Changwen Jin
BIOMOLECULAR NMR ASSIGNMENTS
(2020)
Article
Neurosciences
Shuaipeng Ma, Tong Zang, Meng-Lu Liu, Chun-Li Zhang
MOLECULAR NEURODEGENERATION
(2020)
Article
Neurosciences
Baojin Ding, Yu Tang, Shuaipeng Ma, Masuma Akter, Meng-Lu Liu, Tong Zang, Chun-Li Zhang
Summary: DYT1 dystonia is a hereditary neurologic movement disorder caused by a mutation in the TOR1A gene encoding an ATPase. Modeling the disease using patient-specific neurons revealed that dysregulation of the nuclear lamina protein LMNB1 could be a major molecular mechanism underlying DYT1 pathology.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Lei-Lei Wang, Carolina Serrano, Xiaoling Zhong, Shuaipeng Ma, Yuhua Zou, Chun-Li Zhang
Summary: Recent studies have shown that in vivo cell fate conversions may not actually be converting astrocytes into neurons, but instead utilizing endogenous neurons. Lineage tracing strategies are necessary to accurately track the origin of converted cells, highlighting the importance of applying stringent tracing techniques in studies of cell fate conversions in vivo.
Article
Biochemical Research Methods
Tanushree Halder, Elke Stroeher, Hui Liu, Yinglong Chen, Guijun Yan, Kadambot H. M. Siddique
Summary: Improving the root system of wheat is crucial for enhancing grain yield and climate resilience. This study identified proteins associated with root length and root mass in wheat using label-free quantitative proteomics. The findings revealed potential biomarkers that could be used for improving the root system of wheat.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Yinhua Pan, Quanqing Zou, Wu Yin, Zhen Huang, Yingzhu Zhao, Zongming Mo, Lihui Li, Jianrong Yang
Summary: A prognostic model of BC based on LNM-related genes was established in this study, providing guidance for prognosis evaluation and precise treatment of BC. The genes related to lymph node metastasis in BC are largely unknown and need further exploration. Searching for potential lymph node metastasis-related genes of BC will provide meaningful biomarkers for BC treatment. Our model, based on TCGA-BRCA data, effectively predicted patient outcomes and classified BC patients. The identified feature genes might have a predictive function in immunotherapy. The results of this study provide a new reference for the prognosis and treatment of BC patients with lymph node metastasis.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Qiushi Liang, Joon M. Pijnenburg, Erikjan Rijkers, Arnold G. Vulto, Ans T. van der Ploeg, Niek P. van Til, Eva C. Vlaar, Jeroen A. A. Demmers, W. W. M. Pim Pijnappel
Summary: Pompe disease is a lysosomal storage disorder characterized by glycogen accumulation in skeletal muscle, leading to profound pathology. This study showed that lentiviral gene therapy with LV-IGF2.GAAco can nearly completely correct disease-associated proteomic changes, supporting its future clinical development as a new treatment option for Pompe disease.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Chuang Liu, Wenjing Zhang, Qianli Dong, Haipeng Liu
Summary: This study fills the knowledge gap about the matrix proteins involved in the formation of mineralized exoskeletons in decapod crustaceans. By comparing with well-studied molluscan biomineralization proteins, it is proposed that decapod crustaceans evolved novel proteins while sharing some proteins with molluscs. This study provides insights into the evolution and adaptation of crustaceans and molluscs in forming their exoskeletons.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Rania D. Baka, Josipa Kules, Angelo Beletic, Vladimir Farkas, Dina Resetar Maslov, Blanka Beer Ljubic, Ivana Rubic, Vladimir Mrljak, Mark McLaughlin, David Eckersall, Zoe Polizopoulou
Summary: This study analyzed serum samples from dogs with epilepsy and identified potential markers of epilepsy, proteins involved in nerve tissue regeneration, and proteins altered by antiepileptic medication. The findings provide insight into the pathogenesis of epilepsy and the effects of medication on extracellular matrix proteins.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Viviane M. Codognoto, Fabiana F. de Souza, Thais R. Cataldi, Carlos A. Labate, Laiza S. de Camargo, Pedro H. Esteves Trindade, Roberto R. da Rosa Filho, Diego J. B. de Oliveira, Eunice Oba
Summary: This study aimed to compare urine proteomics from non- and pregnant buffaloes to identify potential biomarkers of early pregnancy. A total of 798 proteins were reported in the urine considering all groups, and the differential proteins play essential roles during pregnancy.
JOURNAL OF PROTEOMICS
(2024)