Unraveling the Molecular Mechanism of Immunosenescence in Drosophila

Stress resistance and lifespan enhanced by downregulation of antimicrobial peptide genes in the Imd pathway

(2018) Yuh-Ru Lin et al.   Aging-US

Overexpression of antimicrobial peptides contributes to aging through cytotoxic effects in Drosophila tissues

(2018) Marziyeh Badinloo et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

Dehydration triggers ecdysone-mediated recognition-protein priming and elevated anti-bacterial immune responses in Drosophila Malpighian tubule renal cells

(2018) Wenjing Zheng et al.   BMC BIOLOGY

Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension

(2018) James H. Catterson et al.   CURRENT BIOLOGY

Comparative Analysis of Drosophila melanogaster Gut Microbiota with Respect to Host Strain, Sex, and Age

(2017) Gangsik Han et al.   MICROBIAL ECOLOGY

Antimicrobial peptides extend lifespan in Drosophila

(2017) Gerrit Loch et al.   PLoS One

Gastrointestinal stem cells in health and disease: from flies to humans

(2016) Hongjie Li et al.   Disease Models & Mechanisms

Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

(2016) Jennifer C Regan et al.   eLife

The insulin receptor substrate Chico regulates antibacterial immune function in Drosophila

(2016) Sarah McCormack et al.   Immunity & Ageing

Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes

(2015) Ekaterina N. Proshkina et al.   AGEING RESEARCH REVIEWS

Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality

(2015) Rebecca I. Clark et al.   Cell Reports

Microbes Promote Amino Acid Harvest to Rescue Undernutrition in Drosophila

(2015) Ryuichi Yamada et al.   Cell Reports

Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia

(2014) Haiyang Chen et al.   CELL

PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan

(2014) Linlin Guo et al.   CELL

Transient adult microbiota, gut homeostasis and longevity: Novel insights from the Drosophila model

(2014) Berra Erkosar et al.   FEBS LETTERS

Gut microbiota–generated metabolites in animal health and disease

(2014) Won-Jae Lee et al.   Nature Chemical Biology

Insects as a model system for aging studies

(2014) Hye-Yeon Lee et al.   ENTOMOLOGICAL RESEARCH

MicroRNAs as Mediators of the Ageing Process

(2014) Lorna Harries   Genes

Juvenile hormone regulation of Drosophila aging

(2013) Rochele Yamamoto et al.   BMC BIOLOGY

Bacterial-Derived Uracil as a Modulator of Mucosal Immunity and Gut-Microbe Homeostasis in Drosophila

(2013) Kyung-Ah Lee et al.   CELL

Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity

(2013) Florentina Rus et al.   EMBO JOURNAL

The inconstant gut microbiota of Drosophila species revealed by 16S rRNA gene analysis

(2013) Adam C-N Wong et al.   ISME Journal

Frequent Replenishment Sustains the Beneficial Microbiome of Drosophila melanogaster

(2013) J. E. Blum et al.   mBio

Misregulation of an Adaptive Metabolic Response Contributes to the Age-Related Disruption of Lipid Homeostasis in Drosophila

(2013) Jason Karpac et al.   Cell Reports

Immunosenescence-associated microRNAs in age and heart failure

(2012) Timon Seeger et al.   EUROPEAN JOURNAL OF HEART FAILURE

Molecular Mechanisms of Aging and Immune System Regulation in Drosophila

(2012) Ioannis Eleftherianos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila

(2012) Nan Liu et al.   NATURE

Impact of the Resident Microbiota on the Nutritional Phenotype of Drosophila melanogaster

(2012) Emma V. Ridley et al.   PLoS One

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

(2012) M. Rera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

dFOXO-independent effects of reduced insulin-like signaling inDrosophila

(2011) Cathy Slack et al.   AGING CELL

Positive and negative regulation of the Drosophila immune response

(2011) Kamna Aggarwal et al.   BMB Reports

Lactobacillus plantarum Promotes Drosophila Systemic Growth by Modulating Hormonal Signals through TOR-Dependent Nutrient Sensing

(2011) Gilles Storelli et al.   Cell Metabolism

Identification of putative miRNA involved in Drosophila melanogaster immune response

(2011) Ane Fullaondo et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Conserved microRNA miR-8 in fat body regulates innate immune homeostasis in Drosophila

(2011) In Kyou Choi et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

A Muscle-Specific p38 MAPK/Mef2/MnSOD Pathway Regulates Stress, Motor Function, and Life Span in Drosophila

(2011) Alysia Vrailas-Mortimer et al.   DEVELOPMENTAL CELL

Low-diversity bacterial community in the gut of the fruitfly Drosophila melanogaster

(2011) Chun Nin Adam Wong et al.   ENVIRONMENTAL MICROBIOLOGY

Drosophila Microbiome Modulates Host Developmental and Metabolic Homeostasis via Insulin Signaling

(2011) S. C. Shin et al.   SCIENCE

A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans

(2011) Matthew J. Youngman et al.   PLoS Genetics

Flies selected for longevity retain a young gene expression profile

(2010) Pernille Sarup et al.   AGE

Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor

(2010) Nazif Alic et al.   AGING CELL

Genome-wide regulation of innate immunity by juvenile hormone and 20-hydroxyecdysone in the Bombyx fat body

(2010) Ling Tian et al.   BMC GENOMICS

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Hormonal regulation of Drosophila microRNA let-7 and miR-125 that target innate immunity

(2010) Alina Garbuzov et al.   FLY

FOXO-dependent regulation of innate immune homeostasis

(2010) Thomas Becker et al.   NATURE

Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

(2010) Sebastian Grönke et al.   PLoS Genetics

Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila

(2010) Benoît Biteau et al.   PLoS Genetics

The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner

(2009) Hervé Tricoire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Functional analysis of the Drosophila immune response during aging

(2008) Sean Ramsden et al.   AGING CELL

Hormonal regulation of the humoral innate immune response in Drosophila melanogaster

(2008) T. Flatt et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Innate Immune Homeostasis by the Homeobox Gene Caudal and Commensal-Gut Mutualism in Drosophila

(2008) J.-H. Ryu et al.   SCIENCE

Realized immune response is enhanced in long-lived puc and chico mutants but is unaffected by dietary restriction

(2007) Sergiy Libert et al.   MOLECULAR IMMUNOLOGY