Gastrointestinal stem cells in health and disease: from flies to humans

Preventing Age-Related Decline of Gut Compartmentalization Limits Microbiota Dysbiosis and Extends Lifespan

(2016) Hongjie Li et al.   Cell Host & Microbe

Stem-cell-specific endocytic degradation defects lead to intestinal dysplasia inDrosophila

(2016) Péter Nagy et al.   Disease Models & Mechanisms

Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging

(2015) Katarzyna Siudeja et al.   Cell Stem Cell

Ttk69 acts as a master repressor of enteroendocrine cell specification in Drosophila intestinal stem cell lineages

(2015) Chenhui Wang et al.   DEVELOPMENT

Enteroendocrine cells are generated from stem cells through a distinct progenitor in the adult Drosophila posterior midgut

(2015) X. Zeng et al.   DEVELOPMENT

Generation of enteroendocrine cell diversity in midgut stem cell lineages

(2015) R. Beehler-Evans et al.   DEVELOPMENT

Identification and genetic manipulation of human and mouse oesophageal stem cells

(2015) Youngtae Jeong et al.   GUT

All for one and one for all: Regionalization of the Drosophila intestine

(2015) Nicolas Buchon et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Signal integration by Ca2+ regulates intestinal stem-cell activity

(2015) Hansong Deng et al.   NATURE

Niche appropriation by Drosophila intestinal stem cell tumours

(2015) Parthive H. Patel et al.   NATURE CELL BIOLOGY

Haemocytes control stem cell activity in the Drosophila intestine

(2015) Arshad Ayyaz et al.   NATURE CELL BIOLOGY

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency

(2015) Z. Guo et al.   SCIENCE

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

(2015) M. Vetizou et al.   SCIENCE

Barrett's esophagus: recent insights into pathogenesis and cellular ontogeny

(2015) Harit Kapoor et al.   Translational Research

Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality

(2015) Rebecca I. Clark et al.   Cell Reports

Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut

(2015) Devanjali Dutta et al.   Cell Reports

Opposing Activities of Notch and Wnt Signaling Regulate Intestinal Stem Cells and Gut Homeostasis

(2015) Hua Tian et al.   Cell Reports

PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress

(2015) Lifen Wang et al.   PLoS Genetics

Colorectal cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia

(2014) Haiyang Chen et al.   CELL

PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan

(2014) Linlin Guo et al.   CELL

EGFR and Notch signaling respectively regulate proliferative activity and multiple cell lineage differentiation of Drosophila gastric stem cells

(2014) Chenhui Wang et al.   CELL RESEARCH

Specification of regional intestinal stem cell identity during Drosophila metamorphosis

(2014) Ian Driver et al.   DEVELOPMENT

Regulation ofDrosophilaintestinal stem cell maintenance and differentiation by the transcription factor Escargot

(2014) Mariano A Loza‐Coll et al.   EMBO JOURNAL

Escargotmaintains stemness and suppresses differentiation inDrosophilaintestinal stem cells

(2014) Jerome Korzelius et al.   EMBO JOURNAL

A pSMAD/CDX2 Complex Is Essential for the Intestinalization of Epithelial Metaplasia

(2014) Luigi Mari et al.   Cell Reports

Cellular Heterogeneity in the Mouse Esophagus Implicates the Presence of a Nonquiescent Epithelial Stem Cell Population

(2014) Aaron D. DeWard et al.   Cell Reports

Slit/Robo Signaling Regulates Cell Fate Decisions in the Intestinal Stem Cell Lineage of Drosophila

(2014) Benoît Biteau et al.   Cell Reports

Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut

(2014) Aiguo Tian et al.   eLife

Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells

(2014) Ryan Forster et al.   Stem Cell Reports

Single-Cell Analysis of Proxy Reporter Allele-Marked Epithelial Cells Establishes Intestinal Stem Cell Hierarchy

(2014) Ning Li et al.   Stem Cell Reports

The Digestive Tract ofDrosophila melanogaster

(2013) Bruno Lemaitre et al.   Annual Review of Genetics

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

(2013) Daniel E. Stange et al.   CELL

Sox2 Cooperates with Inflammation-Mediated Stat3 Activation in the Malignant Transformation of Foregut Basal Progenitor Cells

(2013) Kuancan Liu et al.   Cell Stem Cell

Trachea-Derived Dpp Controls Adult Midgut Homeostasis in Drosophila

(2013) Zhouhua Li et al.   DEVELOPMENTAL CELL

A gutsy approach to stem cells and signalling: an interview with Hans Clevers

(2013)   Disease Models & Mechanisms

Injury-induced BMP signaling negatively regulatesDrosophilamidgut homeostasis

(2013) Zheng Guo et al.   JOURNAL OF CELL BIOLOGY

TSC1/2 regulates intestinal stem cell maintenance and lineage differentiation through Rheb-TORC1-S6K but independently of nutritional status or Notch regulation

(2013) Z. Quan et al.   JOURNAL OF CELL SCIENCE

Gut homeostasis in a microbial world: insights from Drosophila melanogaster

(2013) Nicolas Buchon et al.   NATURE REVIEWS MICROBIOLOGY

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

(2013) Nick Barker   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regional Control of Drosophila Gut Stem Cell Proliferation: EGF Establishes GSSC Proliferative Set Point & Controls Emergence from Quiescence

(2013) Marie Strand et al.   PLoS One

Dpp Signaling Determines Regional Stem Cell Identity in the Regenerating Adult Drosophila Gastrointestinal Tract

(2013) Hongjie Li et al.   Cell Reports

Morphological and Molecular Characterization of Adult Midgut Compartmentalization in Drosophila

(2013) Nicolas Buchon et al.   Cell Reports

Physiological and stem cell compartmentalization within the Drosophila midgut

(2013) Alexis Marianes et al.   eLife

Intestinal inflammation and stem cell homeostasis in aging Drosophila melanogaster

(2013) Arshad Ayyaz et al.   Frontiers in Cellular and Infection Microbiology

Bile Acid and Inflammation Activate Gastric Cardia Stem Cells in a Mouse Model of Barrett-Like Metaplasia

(2012) Michael Quante et al.   CANCER CELL

Barrett esophagus

(2012) Michael Quante et al.   CELL CYCLE

Identification of Lineage-Uncommitted, Long-Lived, Label-Retaining Cells in Healthy Human Esophagus and Stomach, and in Metaplastic Esophagus

(2012) Qiuwei Pan et al.   GASTROENTEROLOGY

The gut microbiota in IBD

(2012) Chaysavanh Manichanh et al.   Nature Reviews Gastroenterology & Hepatology

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

(2012) M. Rera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Single Progenitor Population Switches Behavior to Maintain and Repair Esophageal Epithelium

(2012) D. P. Doupe et al.   SCIENCE

Wnt Signaling, Stem Cells, and Cancer of the Gastrointestinal Tract

(2012) A. Schepers et al.   Cold Spring Harbor Perspectives in Biology

Notch-Mediated Suppression of TSC2 Expression Regulates Cell Differentiation in the Drosophila Intestinal Stem Cell Lineage

(2012) Subir Kapuria et al.   PLoS Genetics

Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection

(2011) Nicolas Buchon et al.   BMC BIOLOGY

Altered Modes of Stem Cell Division Drive Adaptive Intestinal Growth

(2011) Lucy Erin O'Brien et al.   CELL

Residual Embryonic Cells as Precursors of a Barrett's-like Metaplasia

(2011) Xia Wang et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog

(2011) Michael Rera et al.   Cell Metabolism

Redox Regulation by Keap1 and Nrf2 Controls Intestinal Stem Cell Proliferation in Drosophila

(2011) Christine E. Hochmuth et al.   Cell Stem Cell

Maintaining Tissue Homeostasis: Dynamic Control of Somatic Stem Cell Activity

(2011) Benoit Biteau et al.   Cell Stem Cell

Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice

(2011) Katrin Arnold et al.   Cell Stem Cell

Regulation of self-renewal and differentiation by the intestinal stem cell niche

(2011) Trevor M. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

EGF signaling regulates the proliferation of intestinal stem cells in Drosophila

(2011) B. Biteau et al.   DEVELOPMENT

Intestinal stem cells in the adult Drosophila midgut

(2011) Huaqi Jiang et al.   EXPERIMENTAL CELL RESEARCH

Tuberous sclerosis complex and Myc coordinate the growth and division ofDrosophilaintestinal stem cells

(2011) Alla Amcheslavsky et al.   JOURNAL OF CELL BIOLOGY

LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett's Esophagus?

(2011) Burkhard HA von Rahden et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Notch signaling in stomach epithelial stem cell homeostasis

(2011) Tae-Hee Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Isolation and in vitro expansion of human colonic stem cells

(2011) Peter Jung et al.   NATURE MEDICINE

Incidence of Adenocarcinoma among Patients with Barrett's Esophagus

(2011) Frederik Hvid-Jensen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quiescent gastric stem cells maintain the adult Drosophila stomach

(2011) M. Strand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin-signaling pathway

(2011) N. H. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

(2011) K. S. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Troy binding to lymphotoxin-α activates NFκB mediated transcription

(2010) Tsuyoshi Hashimoto et al.   CELL CYCLE

Tissue-Resident Adult Stem Cell Populations of Rapidly Self-Renewing Organs

(2010) Nick Barker et al.   Cell Stem Cell

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila

(2010) Huaqi Jiang et al.   Cell Stem Cell

Warts and Yorkie Mediate Intestinal Regeneration by Influencing Stem Cell Proliferation

(2010) Binnaz Kucuk Staley et al.   CURRENT BIOLOGY

The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration

(2010) P. Karpowicz et al.   DEVELOPMENT

Gastric Epithelial Stem Cells

(2010) Jason C. Mills et al.   GASTROENTEROLOGY

Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways

(2010) F. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila

(2010) Benoît Biteau et al.   PLoS Genetics

Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut

(2009) Huaqi Jiang et al.   CELL

Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation

(2009) W.-C. Lee et al.   DEVELOPMENT

EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors

(2009) H. Jiang et al.   DEVELOPMENT

JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage

(2009) Katherine Beebe et al.   DEVELOPMENTAL BIOLOGY

Depletion of the Colonic Epithelial Precursor Cell Compartment Upon Conditional Activation of the Hedgehog Pathway

(2009) Willemijn A. van Dop et al.   GASTROENTEROLOGY

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

(2009) N. Buchon et al.   GENES & DEVELOPMENT

Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility

(2009) Joshua M. Uronis et al.   PLoS One

Paracrine Unpaired Signaling through the JAK/STAT Pathway Controls Self-renewal and Lineage Differentiation of Drosophila Intestinal Stem Cells

(2009) G. Lin et al.   Journal of Molecular Cell Biology

Age-related changes in Drosophila midgut are associated with PVF2, a PDGF/VEGF-like growth factor

(2008) Na-Hyun Choi et al.   AGING CELL

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut

(2008) Benoît Biteau et al.   Cell Stem Cell

Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus

(2008) S J Leedham et al.   GUT

Diagnosis and management of dysplasia in patients with ulcerative colitis and Crohnʼs disease of the colon

(2008) Thomas Ullman et al.   INFLAMMATORY BOWEL DISEASES

A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification

(2008) Jiri Kalabis et al.   JOURNAL OF CLINICAL INVESTIGATION

The stem cell niche

(2008) MR Walker et al.   JOURNAL OF PATHOLOGY

Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells

(2008) Guonan Lin et al.   NATURE

The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling

(2008) Shigeo Takashima et al.   NATURE

Lgr5 marks cycling, yet long-lived, hair follicle stem cells

(2008) Viljar Jaks et al.   NATURE GENETICS

Bmi1 is expressed in vivo in intestinal stem cells

(2008) Eugenio Sangiorgi et al.   NATURE GENETICS