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Title
mTOR and Tumor Cachexia
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 8, Pages 2225
Publisher
MDPI AG
Online
2018-07-30
DOI
10.3390/ijms19082225
References
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Related references
Note: Only part of the references are listed.- Cancer statistics, 2018
- (2018) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Cancer-associated cachexia
- (2018) Vickie E. Baracos et al. Nature Reviews Disease Primers
- Resistance to mTORC1 Inhibitors in Cancer Therapy: From Kinase Mutations to Intratumoral Heterogeneity of Kinase Activity
- (2017) Seraina Faes et al. Oxidative Medicine and Cellular Longevity
- mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass
- (2017) Mee-Sup Yoon Frontiers in Physiology
- Lewis lung carcinoma regulation of mechanical stretch-induced protein synthesis in cultured myotubes
- (2016) Song Gao et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- The pathogenesis and treatment of cardiac atrophy in cancer cachexia
- (2016) Kate T. Murphy AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Molecular pathways leading to loss of skeletal muscle mass in cancer cachexia – can findings from animal models be translated to humans?
- (2016) Tara C. Mueller et al. BMC CANCER
- Mechanisms of metabolic dysfunction in cancer-associated cachexia
- (2016) Michele Petruzzelli et al. GENES & DEVELOPMENT
- Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3 study
- (2016) James C Yao et al. LANCET
- An evolutionarily conserved pathway controls proteasome homeostasis
- (2016) Adrien Rousseau et al. NATURE
- TORC2 Structure and Function
- (2016) Christl Gaubitz et al. TRENDS IN BIOCHEMICAL SCIENCES
- White Adipose Tissue Browning: A Double-edged Sword
- (2016) Abdikarim Abdullahi et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling
- (2016) Xiangzheng Chen et al. Journal of Cachexia Sarcopenia and Muscle
- ActRII blockade protects mice from cancer cachexia and prolongs survival in the presence of anti-cancer treatments
- (2016) Shinji Hatakeyama et al. Skeletal Muscle
- Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer
- (2016) Eva Pigna et al. Scientific Reports
- The Roles of mTOR Complexes in Lipid Metabolism
- (2015) Alexandre Caron et al. Annual Review of Nutrition
- PI3K and AKT: Unfaithful Partners in Cancer
- (2015) Seraina Faes et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma
- (2015) Robert J. Motzer et al. NEW ENGLAND JOURNAL OF MEDICINE
- mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy
- (2015) Jinghui Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex
- (2015) P. Liu et al. Cancer Discovery
- Evaluating potential biomarkers of cachexia and survival in skeletal muscle of upper gastrointestinal cancer patients
- (2015) Nathan A. Stephens et al. Journal of Cachexia Sarcopenia and Muscle
- A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia
- (2014) Michele Petruzzelli et al. Cell Metabolism
- Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia
- (2014) Serkan Kir et al. NATURE
- Depletion of White Adipose Tissue in Cancer Cachexia Syndrome Is Associated with Inflammatory Signaling and Disrupted Circadian Regulation
- (2014) Maria Tsoli et al. PLoS One
- Evidence and Mechanisms of Fat Depletion in Cancer
- (2014) Maryam Ebadi et al. Nutrients
- Autophagic Degradation Contributes to Muscle Wasting in Cancer Cachexia
- (2013) Fabio Penna et al. AMERICAN JOURNAL OF PATHOLOGY
- Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK
- (2013) James P. White et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy
- (2013) Perrine Castets et al. Cell Metabolism
- Prevention of liver cancer cachexia-induced cardiac wasting and heart failure
- (2013) Jochen Springer et al. EUROPEAN HEART JOURNAL
- Skeletal muscle glycoprotein 130's role in Lewis lung carcinoma–induced cachexia
- (2013) Melissa J. Puppa et al. FASEB JOURNAL
- Mechanisms regulating skeletal muscle growth and atrophy
- (2013) Stefano Schiaffino et al. FEBS Journal
- Altered cardiac muscle mTOR regulation during the progression of cancer cachexia in the ApcMin/+ mouse
- (2013) NANDINI D.P.K. MANNE et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- MG132-mediated inhibition of the ubiquitin–proteasome pathway ameliorates cancer cachexia
- (2013) Liuping Zhang et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology
- (2013) Venus Thomanetz et al. JOURNAL OF CELL BIOLOGY
- Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome
- (2013) Brittany L. Jacobs et al. JOURNAL OF PHYSIOLOGY-LONDON
- mTOR kinase structure, mechanism and regulation
- (2013) Haijuan Yang et al. NATURE
- Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1
- (2013) I. Ben-Sahra et al. SCIENCE
- Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis
- (2013) A. M. Robitaille et al. SCIENCE
- BSTA Promotes mTORC2-Mediated Phosphorylation of Akt1 to Suppress Expression of FoxC2 and Stimulate Adipocyte Differentiation
- (2013) Y. Yao et al. Science Signaling
- Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
- (2012) Asami Hagiwara et al. Cell Metabolism
- Cancer Cachexia: Mediators, Signaling, and Metabolic Pathways
- (2012) Kenneth C.H. Fearon et al. Cell Metabolism
- Connecting mTORC1 signaling to SREBP-1 activation
- (2012) Inan Bakan et al. CURRENT OPINION IN LIPIDOLOGY
- Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2
- (2012) Minsheng Yuan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Heterogeneous time-dependent response of adipose tissue during the development of cancer cachexia
- (2012) M L Batista et al. JOURNAL OF ENDOCRINOLOGY
- The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue
- (2012) Maria J. Pereira et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
- (2012) Christian C. Dibble et al. MOLECULAR CELL
- PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12
- (2012) Xiaoqing Gan et al. NATURE CELL BIOLOGY
- Understanding the mechanisms and treatment options in cancer cachexia
- (2012) Kenneth Fearon et al. Nature Reviews Clinical Oncology
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
- (2012) D. W. Lamming et al. SCIENCE
- Targeting Protein Synthesis in a Myc/mTOR-Driven Model of Anorexia-Cachexia Syndrome Delays Its Onset and Prolongs Survival
- (2011) F. Robert et al. CANCER RESEARCH
- Activation of mTORC2 by Association with the Ribosome
- (2011) Vittoria Zinzalla et al. CELL
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- (2011) Jessica L. Yecies et al. Cell Metabolism
- Low Levels of Lipogenic Enzymes in Peritumoral Adipose Tissue of Colorectal Cancer Patients
- (2011) Maria Notarnicola et al. LIPIDS
- Pre-cachexia in patients with stages I–III non-small cell lung cancer: Systemic inflammation and functional impairment without activation of skeletal muscle ubiquitin proteasome system
- (2011) C.M. Op den Kamp et al. LUNG CANCER
- Rapamycin passes the torch: a new generation of mTOR inhibitors
- (2011) Don Benjamin et al. NATURE REVIEWS DRUG DISCOVERY
- Everolimus for Advanced Pancreatic Neuroendocrine Tumors
- (2011) James C. Yao et al. NEW ENGLAND JOURNAL OF MEDICINE
- Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer
- (2011) José Baselga et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Regulation of Skeletal Muscle Protein Turnover during the Progression of Cancer Cachexia in the ApcMin/+ Mouse
- (2011) James P. White et al. PLoS One
- Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
- (2011) Y. Yu et al. SCIENCE
- The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
- (2011) P. P. Hsu et al. SCIENCE
- Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia
- (2011) S. K. Das et al. SCIENCE
- The effect of exercise on IL-6-induced cachexia in theApcMin/+mouse
- (2011) Melissa J. Puppa et al. Journal of Cachexia Sarcopenia and Muscle
- Adipose tissue pathways involved in weight loss of cancer cachexia
- (2010) I Dahlman et al. BRITISH JOURNAL OF CANCER
- Cancer Causes Cardiac Atrophy and Autophagy in a Sexually Dimorphic Manner
- (2010) P. F. Cosper et al. CANCER RESEARCH
- Role of β1-adrenoceptor in increased lipolysis in cancer cachexia
- (2010) Dong-xing Cao et al. CANCER SCIENCE
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
- (2010) Yasemin Sancak et al. CELL
- Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism
- (2010) A. Kumar et al. DIABETES
- Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage
- (2010) P. Chakrabarti et al. DIABETES
- Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue
- (2010) V. P. Houde et al. DIABETES
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
- (2009) Timothy R. Peterson et al. CELL
- Autophagy Is Required to Maintain Muscle Mass
- (2009) Eva Masiero et al. Cell Metabolism
- Loss of adipose tissue and plasma phospholipids: Relationship to survival in advanced cancer patients
- (2009) R.A. Murphy et al. CLINICAL NUTRITION
- mTOR and cancer: many loops in one pathway
- (2009) Alejo Efeyan et al. CURRENT OPINION IN CELL BIOLOGY
- Muscle atrophy in experimental cancer cachexia: Is the IGF-1 signaling pathway involved?
- (2009) Fabio Penna et al. INTERNATIONAL JOURNAL OF CANCER
- An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
- (2009) Carson C. Thoreen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy
- (2009) Valérie Risson et al. JOURNAL OF CELL BIOLOGY
- Phase III Study to Evaluate Temsirolimus Compared With Investigator's Choice Therapy for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma
- (2009) Georg Hess et al. JOURNAL OF CLINICAL ONCOLOGY
- Rapamycin Protects Against High Fat Diet–Induced Obesity in C57BL/6J Mice
- (2009) Geng-Ruei Chang et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
- (2009) Hui H. Zhang et al. PLoS One
- mTOR complex 2 in adipose tissue negatively controls whole-body growth
- (2009) N. Cybulski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
- (2008) Thomas Porstmann et al. Cell Metabolism
- Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
- (2008) Pazit Polak et al. Cell Metabolism
- Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
- (2008) C. Florian Bentzinger et al. Cell Metabolism
- Computational modeling of cancer cachexia
- (2008) Kevin D Hall et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- Cachexia Worsens Prognosis in Patients with Resectable Pancreatic Cancer
- (2008) Jeannine Bachmann et al. JOURNAL OF GASTROINTESTINAL SURGERY
- Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
- (2008) Robert J Motzer et al. LANCET
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
- Interleukin-6 and cachexia in ApcMin/+ mice
- (2007) Kristen A. Baltgalvis et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy
- (2007) Espen E. Spangenburg et al. JOURNAL OF PHYSIOLOGY-LONDON
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