Molecular Mechanisms Underlying the Effects of Statins in the Central Nervous System

Protective effects of some statins on epileptogenesis and depressive-like behavior in WAG/Rij rats, a genetic animal model of absence epilepsy

(2014) Rita Citraro et al.   EPILEPSIA

Neuroprotective effects of rosuvastatin against traumatic spinal cord injury in rats

(2014) Ramazan Kahveci et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hyperlipidemia, statin use and the risk of developing depression: a nationwide retrospective cohort study

(2014) Chieh-Sen Chuang et al.   GENERAL HOSPITAL PSYCHIATRY

Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial

(2014) Jeremy Chataway et al.   LANCET

Cognitive decline and depressive symptoms in late-life are associated with statin use: evidence from a population-based study of Sardinian old people living in their own home

(2014) Antonella Mandas et al.   NEUROLOGICAL RESEARCH

Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress

(2014) Pao-Yen Lin et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Initiation of statin therapy after acute myocardial infarction is not associated with worsening depressive symptoms: Insights from the Prospective Registry Evaluating Outcomes After Myocardial Infarctions: Events and Recovery (PREMIER) and Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH) registries

(2013) Firas J. Al Badarin et al.   AMERICAN HEART JOURNAL

Statins use and risk of depression: A systematic review and meta-analysis

(2013) Ajay K. Parsaik et al.   JOURNAL OF AFFECTIVE DISORDERS

A Prospective Study of Statin Use and Poststroke Depression

(2013) Jae-Min Kim et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Simvastatin for cognitive deficits and behavioural problems in patients with neurofibromatosis type 1 (NF1-SIMCODA): a randomised, placebo-controlled trial

(2013) Thijs van der Vaart et al.   LANCET NEUROLOGY

Statins and Cognition: A Systematic Review and Meta-analysis of Short- and Long-term Cognitive Effects

(2013) Kristopher J. Swiger et al.   MAYO CLINIC PROCEEDINGS

The THRombolysis and STatins (THRaST) study

(2013) M. Cappellari et al.   NEUROLOGY

Discontinuation of statin therapy associates with Parkinson disease: A population-based study

(2013) Y.-C. Lee et al.   NEUROLOGY

Psychologic Disorders and Statin Use: A Propensity Score-Matched Analysis

(2013) Ishak Mansi et al.   PHARMACOTHERAPY

Statin Therapy and Outcome After Ischemic Stroke

(2013) Danielle Ní Chróinín et al.   STROKE

Simvastatin Promotes Adult Hippocampal Neurogenesis by Enhancing Wnt/β-Catenin Signaling

(2013) Nicholas C. Robin et al.   Stem Cell Reports

Is Statin-Associated Cognitive Impairment Clinically Relevant? A Narrative Review and Clinical Recommendations

(2012) Carlos H Rojas-Fernandez et al.   ANNALS OF PHARMACOTHERAPY

Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms

(2012) Anil Kumar et al.   BRAIN RESEARCH

Simvastatin Induces Neuroprotection in 6-OHDA-Lesioned PC12 via the PI3K/AKT/Caspase 3 Pathway and Anti-Inflammatory Responses

(2012) Yun-Qi Xu et al.   CNS Neuroscience & Therapeutics

Acute atorvastatin treatment exerts antidepressant-like effect in mice via the l-arginine–nitric oxide–cyclic guanosine monophosphate pathway and increases BDNF levels

(2012) Fabiana K. Ludka et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Lovastatin-induced apoptosis is modulated by geranylgeraniol in a neuroblastoma cell line

(2012) Annalisa Marcuzzi et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Statin Use and Risk of Depression in Patients With Coronary Heart Disease

(2012) Christian Otte et al.   JOURNAL OF CLINICAL PSYCHIATRY

Age-Dependent Rescue by Simvastatin of Alzheimer's Disease Cerebrovascular and Memory Deficits

(2012) X.-K. Tong et al.   JOURNAL OF NEUROSCIENCE

Statins for people at low risk of cardiovascular disease – Authors' reply

(2012) Borislava Mihaylova et al.   LANCET

Statins Reduce Amyloid β-Peptide Production by Modulating Amyloid Precursor Protein Maturation and Phosphorylation Through a Cholesterol-Independent Mechanism in Cultured Neurons

(2012) Ai Hosaka et al.   NEUROCHEMICAL RESEARCH

Inpatient statin use predicts improved ischemic stroke discharge disposition

(2012) A. C. Flint et al.   NEUROLOGY

Simvastatin mobilizes bone marrow stromal cells migrating to injured areas and promotes functional recovery after spinal cord injury in the rat

(2012) Xiaoguang Han et al.   NEUROSCIENCE LETTERS

Statin Use and Reduced Cancer-Related Mortality

(2012) Sune F. Nielsen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Simvastatin decreases levodopa-induced dyskinesia in monkeys, but not in a randomized, placebo-controlled, multiple cross-over (“n-of-1”) exploratory trial of simvastatin against levodopa-induced dyskinesia in Parkinson's disease patients

(2012) François Tison et al.   PARKINSONISM & RELATED DISORDERS

Statin Therapy and the Risk of Intracerebral Hemorrhage

(2012) James S. McKinney et al.   STROKE

Pleiotropic effects of pitavastatin

(2011) Jean Davignon   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Statins and their influence on brain cholesterol

(2011) L'ubica Cibičková   Journal of Clinical Lipidology

Statin-induced apoptosis via the suppression of ERK1/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma

(2011) Masashi Yanae et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The neuroprotective effect of two statins: simvastatin and pravastatin on a streptozotocin-induced model of Alzheimer’s disease in rats

(2011) Ana Carolina Tramontina et al.   JOURNAL OF NEURAL TRANSMISSION

Statins, Risk of Dementia, and Cognitive Function: Secondary Analysis of the Ginkgo Evaluation of Memory Study

(2011) Kerstin Bettermann et al.   Journal of Stroke & Cerebrovascular Diseases

Does statin in the acute phase of ischemic stroke improve outcome after intravenous thrombolysis? A retrospective study

(2011) Manuel Cappellari et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation

(2011) R.A. Mans et al.   NEUROSCIENCE

Neurodegeneration and Inflammation in Parkinson's disease

(2011) Sudarshan Phani et al.   PARKINSONISM & RELATED DISORDERS

Lovastatin as Treatment for Neurocognitive Deficits in Neurofibromatosis Type 1: Phase I Study

(2011) Maria T. Acosta et al.   PEDIATRIC NEUROLOGY

Simvastatin Prevents Dopaminergic Neurodegeneration in Experimental Parkinsonian Models: The Association with Anti-Inflammatory Responses

(2011) Junqiang Yan et al.   PLoS One

Statin Use During Ischemic Stroke Hospitalization Is Strongly Associated With Improved Poststroke Survival

(2011) Alexander C. Flint et al.   STROKE

Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice

(2010) Tomoko Kurata et al.   BRAIN RESEARCH

Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β1–40 administration in mice: Evidence for dissociation between cognitive deficits and neuronal damage

(2010) Tetsadê C.B. Piermartiri et al.   EXPERIMENTAL NEUROLOGY

Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells

(2010) Ajaib S. Paintlia et al.   GLIA

Differential interactions between statins and P-glycoprotein: Implications for exploiting statins as anticancer agents

(2010) Carolyn A. Goard et al.   INTERNATIONAL JOURNAL OF CANCER

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

(2010) Irfan Y. Tamboli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance

(2010) Mitsuru Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Use of Statins After a Cardiac Intervention Is Associated With Reduced Risk of Subsequent Depression

(2010) Lesley Stafford et al.   JOURNAL OF CLINICAL PSYCHIATRY

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

(2010)   LANCET

Statin use and risk of epilepsy: A nested case-control study

(2010) M. Etminan et al.   NEUROLOGY

Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF

(2010) Xiaoguang Han et al.   NEUROSCIENCE LETTERS

Neuroprotective Effect of Atorvastatin in an Experimental Model of Nerve Crush Injury

(2010) Hung-Chuan Pan et al.   NEUROSURGERY

Statin use and depressive symptoms in a prospective study of community-living older persons

(2010) Liang Feng et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: A novel mechanism of action

(2010) Eugenio Barone et al.   PHARMACOLOGICAL RESEARCH

Cholesterol as a Risk Factor for Dementia and Cognitive Decline: A Systematic Review of Prospective Studies With Meta-Analysis

(2009) Kaarin J. Anstey et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Statin Therapy Inhibits Remyelination in the Central Nervous System

(2009) Veronique E. Miron et al.   AMERICAN JOURNAL OF PATHOLOGY

Transporter Pharmacogenetics and Statin Toxicity

(2009) M Niemi   CLINICAL PHARMACOLOGY & THERAPEUTICS

Lack of robust neurologic benefits with simvastatin or atorvastatin treatment after acute thoracic spinal cord contusion injury

(2009) Cody M. Mann et al.   EXPERIMENTAL NEUROLOGY

Targeting eNOS and beyond: emerging heterogeneity of the role of endothelial Rho proteins in stroke protection

(2009) Naoki Sawada et al.   Expert Review of Neurotherapeutics

Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats

(2009) Katja Nieweg et al.   JOURNAL OF NEUROCHEMISTRY

Simvastatin Inhibits the Activation of p21ras and Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson's Disease

(2009) A. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Statin's Excitoprotection Is Mediated by sAPP and the Subsequent Attenuation of Calpain-Induced Truncation Events, Likely via Rho-ROCK Signaling

(2009) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice

(2009) Xin-Kang Tong et al.   NEUROBIOLOGY OF DISEASE

Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients

(2009) Gunter P. Eckert et al.   NEUROBIOLOGY OF DISEASE

Atorvastatin prevents early apoptosis after thoracic spinal cord contusion injury and promotes locomotion recovery

(2009) Marc-André Déry et al.   NEUROSCIENCE LETTERS

Atorvastatin Prevents Hippocampal Cell Death due to Quinolinic Acid-Induced Seizures in Mice by Increasing Akt Phosphorylation and Glutamate Uptake

(2009) Tetsadê C. B. Piermartiri et al.   NEUROTOXICITY RESEARCH

Reduced Risk of Incident AD with Elective Statin Use in a Clinical Trial Cohort

(2008) D. Sparks et al.   Current Alzheimer Research

Association between Depressive Symptoms and Use of HMG-CoA Reductase Inhibitors (Statins), Corticosteroids and Histamine H2 Receptor Antagonists in Community-Dwelling Older Persons

(2008) Liang Feng et al.   DRUGS & AGING

Statin treatment of adult human glial progenitors induces PPARγ-mediated oligodendrocytic differentiation

(2008) Fraser J. Sim et al.   GLIA

Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microglia

(2008) Moon-Sook Woo et al.   JOURNAL OF NEUROCHEMISTRY

Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study

(2008) M D M Haag et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Negative Impact of Statins on Oligodendrocytes and Myelin Formation In Vitro and In Vivo

(2008) S. Klopfleisch et al.   JOURNAL OF NEUROSCIENCE

Simvastatin-Mediated Upregulation of VEGF and BDNF, Activation of the PI3K/Akt Pathway, and Increase of Neurogenesis Are Associated with Therapeutic Improvement after Traumatic Brain Injury

(2008) Hongtao Wu et al.   JOURNAL OF NEUROTRAUMA

Inhibition of Rho Family Functions by Lovastatin Promotes Myelin Repair in Ameliorating Experimental Autoimmune Encephalomyelitis

(2008) A. S. Paintlia et al.   MOLECULAR PHARMACOLOGY

Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death

(2008) Jin-Koo Lee et al.   NEUROSCIENCE LETTERS

Simvastatin Reduces the Association of NMDA Receptors to Lipid Rafts

(2008) Jovita Ponce et al.   STROKE