Optimization of the Bacterial Cytochrome P450 BM3 System for the Production of Human Drug Metabolites

A novel type of allosteric regulation: Functional cooperativity in monomeric proteins

(2012) Ilia G. Denisov et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Drug–drug interactions and cooperative effects detected in electrochemically driven human cytochrome P450 3A4

(2012) Sheila J. Sadeghi et al.   BIOELECTROCHEMISTRY

A Single Active Site Mutation Inverts Stereoselectivity of 16-Hydroxylation of Testosterone Catalyzed by Engineered Cytochrome P450 BM3

(2012) Harini Venkataraman et al.   CHEMBIOCHEM

Identification of Mutant Asp251Gly/Gln307His of Cytochrome P450 BM3 for the Generation of Metabolites of Diclofenac, Ibuprofen and Tolbutamide

(2012) Georgia E. Tsotsou et al.   CHEMISTRY-A EUROPEAN JOURNAL

First steps towards a Zn/Co(III)sep-driven P450 BM3 reactor

(2011) Liqing Zhao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Allosteric Activation of Cytochrome P450 3A4 by α-Naphthoflavone: Branch Point Regulation Revealed by Isotope Dilution Analysis

(2011) Caleb M. Woods et al.   BIOCHEMISTRY

The Structural Basis for Homotropic and Heterotropic Cooperativity of Midazolam Metabolism by Human Cytochrome P450 3A4

(2011) Arthur G. Roberts et al.   BIOCHEMISTRY

A Single Active-Site Mutation of P450BM-3 Dramatically Enhances Substrate Binding and Rate of Product Formation

(2011) Donovan C. Haines et al.   BIOCHEMISTRY

Active Site Substitution A82W Improves the Regioselectivity of Steroid Hydroxylation by Cytochrome P450 BM3 Mutants As Rationalized by Spin Relaxation Nuclear Magnetic Resonance Studies

(2011) V. Rea et al.   BIOCHEMISTRY

Engineered Bacterial Mimics of Human Drug Metabolizing Enzyme CYP2C9

(2011) Andrea Rentmeister et al.   ChemCatChem

P450BM3(CYP102A1): connecting the dots

(2011) Christopher J. C. Whitehouse et al.   CHEMICAL SOCIETY REVIEWS

Efficient Screening of Cytochrome P450 BM3 Mutants for Their Metabolic Activity and Diversity toward a Wide Set of Drug-Like Molecules in Chemical Space

(2011) J. Reinen et al.   DRUG METABOLISM AND DISPOSITION

Surface Display of Heme- and Diflavin-Containing Cytochrome P450 BM3 in Escherichia coli: A Whole-Cell Biocatalyst for Oxidation

(2011) Sung-Kun Yim   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Facile production of minor metabolites for drug development using a CYP3A shuffled library

(2011) D.J.B. Hunter et al.   METABOLIC ENGINEERING

An Electrochemical Microfluidic Platform for Human P450 Drug Metabolism Profiling

(2010) Andrea Fantuzzi et al.   ANALYTICAL CHEMISTRY

Breakthrough in P450 bioelectrochemistry and future perspectives

(2010) Sheila J. Sadeghi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Engineering Bacterial Cytochrome P450 (P450) BM3 into a Prototype with Human P450 Enzyme Activity Using Indigo Formation

(2010) S. H. Park et al.   DRUG METABOLISM AND DISPOSITION

Generation of Human Chiral Metabolites of Simvastatin and Lovastatin by Bacterial CYP102A1 Mutants

(2010) K.-H. Kim et al.   DRUG METABOLISM AND DISPOSITION

Engineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediation

(2010) Santosh Kumar   Expert Opinion on Drug Metabolism & Toxicology

Analysis of Heterotropic Cooperativity in Cytochrome P450 3A4 Using α-Naphthoflavone and Testosterone

(2010) Daniel J. Frank et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immobilization of P450 BM-3 monooxygenase on mesoporous molecular sieves with different pore diameters

(2010) Evelyne Weber et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Metabolism related toxicity of diclofenac in yeast as model system

(2010) Jolanda S. van Leeuwen et al.   TOXICOLOGY LETTERS

Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity

(2010) Harshica Fernando et al.   XENOBIOTICA

A Diversified Library of Bacterial and Fungal Bifunctional Cytochrome P450 Enzymes for Drug Metabolite Synthesis

(2009) Roland Weis et al.   ADVANCED SYNTHESIS & CATALYSIS

How Common Is Diclofenac-Associated Liver Injury? Analysis of 17,289 Arthritis Patients in a Long-Term Prospective Clinical Trial

(2009) Loren Laine et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

P450BM-3-catalyzed whole-cell biotransformation of α-pinene with recombinant Escherichia coli in an aqueous–organic two-phase system

(2009) Hendrik Schewe et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Mixing apples and oranges: Analysis of heterotropic cooperativity in cytochrome P450 3A4

(2009) Daniel J. Frank et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Entrapment of cytochrome P450 BM-3 in polypyrrole for electrochemically-driven biocatalysis

(2009) Dirk Holtmann et al.   BIOTECHNOLOGY LETTERS

A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites and Diversify Lead Compounds

(2009) Andrew M. Sawayama et al.   CHEMISTRY-A EUROPEAN JOURNAL

Generation of the Human Metabolite Piceatannol from the Anticancer-Preventive Agent Resveratrol by Bacterial Cytochrome P450 BM3

(2009) D.-H. Kim et al.   DRUG METABOLISM AND DISPOSITION

Versatile capacity of shuffled cytochrome P450s for dye production

(2008) Nedeljka N. Rosic   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Engineering Cytochrome P450 Enzymes for Improved Activity towards Biomimetic 1,4-NADH Cofactors

(2008) Jessica D. Ryan et al.   CHEMBIOCHEM

Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s

(2008) Bo Wen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Metabolism of Atypical Antipsychotics: Involvement of Cytochrome P450 Enzymes and Relevance for Drug-Drug Interactions

(2008) Liana Urichuk et al.   CURRENT DRUG METABOLISM

Heme-iron oxygenases: powerful industrial biocatalysts?

(2008) Mattijs K Julsing et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Generation of Human Metabolites of 7-Ethoxycoumarin by Bacterial Cytochrome P450 BM3

(2008) D.-H. Kim et al.   DRUG METABOLISM AND DISPOSITION

Modulating the coupling efficiency of human cytochrome P450 CYP3A4 at electrode surfaces through protein engineering

(2008) Vikash R. Dodhia et al.   ELECTROCHEMISTRY COMMUNICATIONS

Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites

(2007) Micaela C. Damsten et al.   CHEMICO-BIOLOGICAL INTERACTIONS