Optimization of the Bacterial Cytochrome P450 BM3 System for the Production of Human Drug Metabolites
出版年份 2012 全文链接
标题
Optimization of the Bacterial Cytochrome P450 BM3 System for the Production of Human Drug Metabolites
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 13, Issue 12, Pages 15901-15924
出版商
MDPI AG
发表日期
2012-11-29
DOI
10.3390/ijms131215901
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A novel type of allosteric regulation: Functional cooperativity in monomeric proteins
- (2012) Ilia G. Denisov et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Drug–drug interactions and cooperative effects detected in electrochemically driven human cytochrome P450 3A4
- (2012) Sheila J. Sadeghi et al. BIOELECTROCHEMISTRY
- A Single Active Site Mutation Inverts Stereoselectivity of 16-Hydroxylation of Testosterone Catalyzed by Engineered Cytochrome P450 BM3
- (2012) Harini Venkataraman et al. CHEMBIOCHEM
- Identification of Mutant Asp251Gly/Gln307His of Cytochrome P450 BM3 for the Generation of Metabolites of Diclofenac, Ibuprofen and Tolbutamide
- (2012) Georgia E. Tsotsou et al. CHEMISTRY-A EUROPEAN JOURNAL
- First steps towards a Zn/Co(III)sep-driven P450 BM3 reactor
- (2011) Liqing Zhao et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Allosteric Activation of Cytochrome P450 3A4 by α-Naphthoflavone: Branch Point Regulation Revealed by Isotope Dilution Analysis
- (2011) Caleb M. Woods et al. BIOCHEMISTRY
- The Structural Basis for Homotropic and Heterotropic Cooperativity of Midazolam Metabolism by Human Cytochrome P450 3A4
- (2011) Arthur G. Roberts et al. BIOCHEMISTRY
- A Single Active-Site Mutation of P450BM-3 Dramatically Enhances Substrate Binding and Rate of Product Formation
- (2011) Donovan C. Haines et al. BIOCHEMISTRY
- Active Site Substitution A82W Improves the Regioselectivity of Steroid Hydroxylation by Cytochrome P450 BM3 Mutants As Rationalized by Spin Relaxation Nuclear Magnetic Resonance Studies
- (2011) V. Rea et al. BIOCHEMISTRY
- Engineered Bacterial Mimics of Human Drug Metabolizing Enzyme CYP2C9
- (2011) Andrea Rentmeister et al. ChemCatChem
- P450BM3(CYP102A1): connecting the dots
- (2011) Christopher J. C. Whitehouse et al. CHEMICAL SOCIETY REVIEWS
- Efficient Screening of Cytochrome P450 BM3 Mutants for Their Metabolic Activity and Diversity toward a Wide Set of Drug-Like Molecules in Chemical Space
- (2011) J. Reinen et al. DRUG METABOLISM AND DISPOSITION
- Surface Display of Heme- and Diflavin-Containing Cytochrome P450 BM3 in Escherichia coli: A Whole-Cell Biocatalyst for Oxidation
- (2011) Sung-Kun Yim JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- Facile production of minor metabolites for drug development using a CYP3A shuffled library
- (2011) D.J.B. Hunter et al. METABOLIC ENGINEERING
- An Electrochemical Microfluidic Platform for Human P450 Drug Metabolism Profiling
- (2010) Andrea Fantuzzi et al. ANALYTICAL CHEMISTRY
- Breakthrough in P450 bioelectrochemistry and future perspectives
- (2010) Sheila J. Sadeghi et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Engineering Bacterial Cytochrome P450 (P450) BM3 into a Prototype with Human P450 Enzyme Activity Using Indigo Formation
- (2010) S. H. Park et al. DRUG METABOLISM AND DISPOSITION
- Generation of Human Chiral Metabolites of Simvastatin and Lovastatin by Bacterial CYP102A1 Mutants
- (2010) K.-H. Kim et al. DRUG METABOLISM AND DISPOSITION
- Engineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediation
- (2010) Santosh Kumar Expert Opinion on Drug Metabolism & Toxicology
- Analysis of Heterotropic Cooperativity in Cytochrome P450 3A4 Using α-Naphthoflavone and Testosterone
- (2010) Daniel J. Frank et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Immobilization of P450 BM-3 monooxygenase on mesoporous molecular sieves with different pore diameters
- (2010) Evelyne Weber et al. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
- Metabolism related toxicity of diclofenac in yeast as model system
- (2010) Jolanda S. van Leeuwen et al. TOXICOLOGY LETTERS
- Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity
- (2010) Harshica Fernando et al. XENOBIOTICA
- A Diversified Library of Bacterial and Fungal Bifunctional Cytochrome P450 Enzymes for Drug Metabolite Synthesis
- (2009) Roland Weis et al. ADVANCED SYNTHESIS & CATALYSIS
- How Common Is Diclofenac-Associated Liver Injury? Analysis of 17,289 Arthritis Patients in a Long-Term Prospective Clinical Trial
- (2009) Loren Laine et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- P450BM-3-catalyzed whole-cell biotransformation of α-pinene with recombinant Escherichia coli in an aqueous–organic two-phase system
- (2009) Hendrik Schewe et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Mixing apples and oranges: Analysis of heterotropic cooperativity in cytochrome P450 3A4
- (2009) Daniel J. Frank et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Entrapment of cytochrome P450 BM-3 in polypyrrole for electrochemically-driven biocatalysis
- (2009) Dirk Holtmann et al. BIOTECHNOLOGY LETTERS
- A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites and Diversify Lead Compounds
- (2009) Andrew M. Sawayama et al. CHEMISTRY-A EUROPEAN JOURNAL
- Generation of the Human Metabolite Piceatannol from the Anticancer-Preventive Agent Resveratrol by Bacterial Cytochrome P450 BM3
- (2009) D.-H. Kim et al. DRUG METABOLISM AND DISPOSITION
- Versatile capacity of shuffled cytochrome P450s for dye production
- (2008) Nedeljka N. Rosic APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Engineering Cytochrome P450 Enzymes for Improved Activity towards Biomimetic 1,4-NADH Cofactors
- (2008) Jessica D. Ryan et al. CHEMBIOCHEM
- Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s
- (2008) Bo Wen et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Metabolism of Atypical Antipsychotics: Involvement of Cytochrome P450 Enzymes and Relevance for Drug-Drug Interactions
- (2008) Liana Urichuk et al. CURRENT DRUG METABOLISM
- Heme-iron oxygenases: powerful industrial biocatalysts?
- (2008) Mattijs K Julsing et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Generation of Human Metabolites of 7-Ethoxycoumarin by Bacterial Cytochrome P450 BM3
- (2008) D.-H. Kim et al. DRUG METABOLISM AND DISPOSITION
- Modulating the coupling efficiency of human cytochrome P450 CYP3A4 at electrode surfaces through protein engineering
- (2008) Vikash R. Dodhia et al. ELECTROCHEMISTRY COMMUNICATIONS
- Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites
- (2007) Micaela C. Damsten et al. CHEMICO-BIOLOGICAL INTERACTIONS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started