Engineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediation

Biotechnological Synthesis of the Designer Drug Metabolite 4'-Hydroxymethyl- -pyrrolidinohexanophenone in Fission Yeast Heterologously Expressing Human Cytochrome P450 2D6--A Versatile Alternative to Multistep Chemical Synthesis

(2013) F. T. Peters et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Transgenic Rice Plants Expressing Human P450 Genes Involved in Xenobiotic Metabolism for Phytoremediation

(2010) Hiroyuki Kawahigashi et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Genetic Polymorphism of Metabolic Enzymes P450 (CYP) as a Susceptibility Factor for Drug Response, Toxicity, and Cancer Risk

(2009) Nada Božina et al.   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

Efficient Biotransformations UsingEscherichia coliwithtolCacrABMutations Expressing Cytochrome P450 Genes

(2009) Tadashi FUJII et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Transgenic plants for enhanced biodegradation and phytoremediation of organic xenobiotics

(2009) P.C. Abhilash et al.   BIOTECHNOLOGY ADVANCES

A Highly Active Single-Mutation Variant of P450BM3(CYP102A1)

(2009) Christopher J. C. Whitehouse et al.   CHEMBIOCHEM

Regulation of Cytochrome P450 Expression by Ras- and β-Catenin-Dependent Signaling

(2009) Albert Braeuning   CURRENT DRUG METABOLISM

Transgenic plants for enhanced phytoremediation of toxic explosives

(2009) Benoit Van Aken   CURRENT OPINION IN BIOTECHNOLOGY

Transgenic plants for phytoremediation of herbicides

(2009) Hiroyuki Kawahigashi   CURRENT OPINION IN BIOTECHNOLOGY

Drug interactions

(2009) Alan Boobis et al.   DRUG METABOLISM REVIEWS

Applications of flow cytometry in environmental microbiology and biotechnology

(2009) Peter L. Bergquist et al.   EXTREMOPHILES

Electrochemically Driven Drug Metabolism by Membranes Containing Human Cytochrome P450

(2009) Yasuhiro Mie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CYP450 2B4 covalently attached to carbon and gold screen printed electrodes by diazonium salt and thiols monolayers

(2008) M.A. Alonso-Lomillo et al.   ANALYTICA CHIMICA ACTA

Protein and Electrode Engineering for the Covalent Immobilization of P450 BMP on Gold

(2008) Valentina E. V. Ferrero et al.   ANALYTICAL CHEMISTRY

CYP450 biosensors based on gold chips for antiepileptic drugs determination

(2008) M.A. Alonso-Lomillo et al.   BIOSENSORS & BIOELECTRONICS

Screen-printed electrodes based on carbon nanotubes and cytochrome P450scc for highly sensitive cholesterol biosensors

(2008) Sandro Carrara et al.   BIOSENSORS & BIOELECTRONICS

Genotoxic potential of Polycyclic Aromatic Hydrocarbons-coated onto airborne Particulate Matter (PM2.5) in human lung epithelial A549 cells

(2008) Sylvain Billet et al.   CANCER LETTERS

Evolved CYP102A1 (P450BM3) variants oxidise a range of non-natural substrates and offer new selectivity options

(2008) Christopher J. C. Whitehouse et al.   CHEMICAL COMMUNICATIONS

Advances in laboratory evolution of enzymes

(2008) Shimon Bershtein et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Heme-iron oxygenases: powerful industrial biocatalysts?

(2008) Mattijs K Julsing et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?

(2008) Dmitri R Davydov et al.   Expert Opinion on Drug Metabolism & Toxicology

Identification and Analysis of Conserved Sequence Motifs in Cytochrome P450 Family 2

(2008) Numan Oezguen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of amino acid residues involved in 4-chloroindole 3-hydroxylation by cytochrome P450 2A6 using screening of random libraries

(2008) Zhi-Gang Zhang et al.   JOURNAL OF BIOTECHNOLOGY

Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies

(2008) R. Nicoli et al.   JOURNAL OF CHROMATOGRAPHY A

Novel therapeutic biosensor for indinavir—A protease inhibitor antiretroviral drug

(2008) A. Ignaszak et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Directed enzyme evolution via small and effective neutral drift libraries

(2008) Rinkoo D Gupta et al.   NATURE METHODS

Electrochemistry of cytochrome P450 enzyme on nanoparticle-containing membrane-coated electrode and its applications for drug sensing

(2007) Songqin Liu et al.   ANALYTICAL BIOCHEMISTRY

Cytochrome P450s in the development of target-based anticancer drugs

(2007) Kedar Purnapatre et al.   CANCER LETTERS

Metabolism and Toxicity of Drugs. Two Decades of Progress in Industrial Drug Metabolism

(2007) Thomas A. Baillie   CHEMICAL RESEARCH IN TOXICOLOGY

Engineering Cytochrome P450 Enzymes

(2007) Elizabeth M. J. Gillam   CHEMICAL RESEARCH IN TOXICOLOGY

Cytochrome P450 and Chemical Toxicology

(2007) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY

Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites

(2007) Micaela C. Damsten et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Degradation of Low Molecular Weight Volatile Organic Compounds by Plants Genetically Modified with Mammalian Cytochrome P450 2E1

(2007) C. Andrew James et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY