Identification of Mutant Asp251Gly/Gln307His of Cytochrome P450 BM3 for the Generation of Metabolites of Diclofenac, Ibuprofen and Tolbutamide

Engineered Bacterial Mimics of Human Drug Metabolizing Enzyme CYP2C9

(2011) Andrea Rentmeister et al.   ChemCatChem

Oxidation of human cytochrome P450 1A2 substrates by Bacillus megaterium cytochrome P450 BM3

(2010) Dong-Hyun Kim et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Introduction: Human Metabolites in Safety Testing (MIST) Issue

(2009) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY

A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites and Diversify Lead Compounds

(2009) Andrew M. Sawayama et al.   CHEMISTRY-A EUROPEAN JOURNAL

Generation of the Human Metabolite Piceatannol from the Anticancer-Preventive Agent Resveratrol by Bacterial Cytochrome P450 BM3

(2009) D.-H. Kim et al.   DRUG METABOLISM AND DISPOSITION

Binding of CYP2C9 with Diverse Drugs and its Implications for Metabolic Mechanism

(2009) Jing-Fang Wang et al.   Medicinal Chemistry

Evolved CYP102A1 (P450BM3) variants oxidise a range of non-natural substrates and offer new selectivity options

(2008) Christopher J. C. Whitehouse et al.   CHEMICAL COMMUNICATIONS

Trimethoprim: Novel Reactive Intermediates and Bioactivation Pathways by Cytochrome P450s

(2008) Micaela C. Damsten et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Generation of Human Metabolites of 7-Ethoxycoumarin by Bacterial Cytochrome P450 BM3

(2008) D.-H. Kim et al.   DRUG METABOLISM AND DISPOSITION

Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites

(2007) Micaela C. Damsten et al.   CHEMICO-BIOLOGICAL INTERACTIONS