A Dilemma in the Glycosaminoglycan-Based Therapy: Synthetic or Naturally Unique Molecules?

Anticoagulant and antithrombotic evaluation of native fucosylated chondroitin sulfates and their derivatives as selective inhibitors of intrinsic factor Xase

(2015) Mingyi Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Keratan sulfate: An up-to-date review

(2015) Vitor H. Pomin   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucosylated Chondroitin Sulfate Inhibits Plasmodium falciparum Cytoadhesion and Merozoite Invasion

(2014) Marcele F. Bastos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A heparin-like glycosaminoglycan from shrimp containing high levels of 3-O-sulfated d-glucosamine groups in an unusual trisaccharide sequence

(2014) Suely F. Chavante et al.   CARBOHYDRATE RESEARCH

A multifunctional anomeric linker for the chemoenzymatic synthesis of complex oligosaccharides

(2014) Anthony R. Prudden et al.   CHEMICAL COMMUNICATIONS

Modular automated solid phase synthesis of dermatan sulfate oligosaccharides

(2014) Jeyakumar Kandasamy et al.   CHEMICAL COMMUNICATIONS

Structural and functional analyses of bovine and porcine intestinal heparins confirm they are different drugs

(2014) Gustavo R.C. Santos et al.   DRUG DISCOVERY TODAY

Antitumor properties of a new non-anticoagulant heparin analog from the mollusk Nodipecten nodosus: Effect on P-selectin, heparanase, metastasis and cellular recruitment

(2014) Angélica Maciel Gomes et al.   GLYCOBIOLOGY

Chemoenzymatic synthesis and structural characterization of 2-O-sulfated glucuronic acid-containing heparan sulfate hexasaccharides

(2014) Po-Hung Hsieh et al.   GLYCOBIOLOGY

Holothurian Fucosylated Chondroitin Sulfate

(2014) Vitor Pomin   Marine Drugs

Sea, Carbohydrates and Clotting: A Triad on the Road of Drug Discovery

(2014) Vitor Pomin   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Chemoenzymatic synthesis of heparan sulfate and heparin

(2014) Jian Liu et al.   NATURAL PRODUCT REPORTS

New glucuronic acid donors for the modular synthesis of heparan sulfate oligosaccharides

(2014) Omkar P. Dhamale et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Fluorous-Assisted Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides

(2014) Chao Cai et al.   ORGANIC LETTERS

The Protective Role of Fucosylated Chondroitin Sulfate, a Distinct Glycosaminoglycan, in a Murine Model of Streptozotocin-Induced Diabetic Nephropathy

(2014) Conrado L. R. Gomes et al.   PLoS One

Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites

(2014) M. Nonaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMR Chemical Shifts in Structural Biology of Glycosaminoglycans

(2013) Vitor H. Pomin   ANALYTICAL CHEMISTRY

Automated Solid-Phase Synthesis of Chondroitin Sulfate Glycosaminoglycans

(2013) Steffen Eller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anti-HIV-1 activity and structure–activity-relationship study of a fucosylated glycosaminoglycan from an echinoderm by targeting the conserved CD4 induced epitope

(2013) Wu Lian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Sulfation pattern of the fucose branch is important for the anticoagulant and antithrombotic activities of fucosylated chondroitin sulfates

(2013) Shiguo Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A non-hemorrhagic hybrid heparin/heparan sulfate with anticoagulant potential

(2013) Adriana S. Brito et al.   CARBOHYDRATE POLYMERS

The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry

(2013) Ning Huang et al.   CARBOHYDRATE RESEARCH

Chemoenzymatic synthesis of glycosaminoglycans: Re-creating, re-modeling and re-designing nature's longest or most complex carbohydrate chains

(2013) P. L. DeAngelis et al.   GLYCOBIOLOGY

Comparison of Physicochemical Characteristics and Anticoagulant Activities of Polysaccharides from Three Sea Cucumbers

(2013) Lan Luo et al.   Marine Drugs

Chondroitin Sulfate, Hyaluronic Acid and Chitin/Chitosan Production Using Marine Waste Sources: Characteristics, Applications and Eco-Friendly Processes: A Review

(2013) José Vázquez et al.   Marine Drugs

Wound healing and antibacterial activities of chondroitin sulfate- and acharan sulfate-reduced silver nanoparticles

(2013) A-Rang Im et al.   NANOTECHNOLOGY

Fluorous Supported Modular Synthesis of Heparan Sulfate Oligosaccharides

(2013) Chengli Zong et al.   ORGANIC LETTERS

Fucosylated chondroitin sulfate from Acaudina molpadioides improves hyperglycemia via activation of PKB/GLUT4 signaling in skeletal muscle of insulin resistant mice

(2013) Shiwei Hu et al.   Food & Function

Acylsulfonamide safety-catch linker: promise and limitations for solid–phase oligosaccharide synthesis

(2012) Jian Yin et al.   Beilstein Journal of Organic Chemistry

Residual keratan sulfate in chondroitin sulfate formulations for oral administration

(2012) Vitor H. Pomin et al.   CARBOHYDRATE POLYMERS

Electron detachment dissociation of synthetic heparan sulfate glycosaminoglycan tetrasaccharides varying in degree of sulfation and hexuronic acid stereochemistry

(2012) Franklin E. Leach et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Chemoenzymatic Synthesis of Heparin Oligosaccharides with both Anti-factor Xa and Anti-factor IIa Activities

(2012) Yongmei Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparosan-Derived Heparan Sulfate/Heparin-Like Compounds: One Kind of Potential Therapeutic Agents

(2012) Pingli Li et al.   MEDICINAL RESEARCH REVIEWS

Hyaluronic Acid Hydrogels for Biomedical Applications

(2011) Jason A. Burdick et al.   ADVANCED MATERIALS

Preparation and anticoagulant activity of a fucosylated polysaccharide sulfate from a sea cucumber Acaudina molpadioidea

(2011) Libin Ye et al.   CARBOHYDRATE POLYMERS

Structure and effect of sulfated fucose branches on anticoagulant activity of the fucosylated chondroitin sulfate from sea cucumber Thelenata ananas

(2011) Mingyi Wu et al.   CARBOHYDRATE POLYMERS

Enzymes in the Synthesis of Glycoconjugates

(2011) Ryan M. Schmaltz et al.   CHEMICAL REVIEWS

Inhibition of Helicobacter pylori adhesion to Kato III cells by intact and low molecular weight acharan sulfate

(2011) Joon-Soo Sim et al.   GLYCOCONJUGATE JOURNAL

Ascidian dermatan sulfates attenuate metastasis, inflammation and thrombosis by inhibition of P-selectin

(2011) E. O. KOZLOWSKI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A synthetic heparan sulfate oligosaccharide library reveals the novel enzymatic action ofd-glucosaminyl 3-O-sulfotransferase-3a

(2011) Thao Kim Nu Nguyen et al.   Molecular BioSystems

New developments in the characterization of heparin and its impurities

(2010) Cynthia K. Larive   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Comparison of structures and anticoagulant activities of fucosylated chondroitin sulfates from different sea cucumbers

(2010) Shiguo Chen et al.   CARBOHYDRATE POLYMERS

Chemoenzymatic Design of Heparan Sulfate Oligosaccharides

(2010) Renpeng Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Extracellular Matrix Heparan Sulfate from the BivalveNodipecten nodosus(Linnaeus, 1758) Safely Inhibits Arterial Thrombosis after Photochemically Induced Endothelial Lesion

(2010) Angélica M. Gomes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of nucleolin translocation by acharan sulfate in A549 human lung adenocarcinoma

(2010) Eun Ji Joo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effects of oversulfated and fucosylated chondroitin sulfates on coagulation

(2010) Roberto Fonseca et al.   THROMBOSIS AND HAEMOSTASIS

Tainted heparin crisis tested FDA’s investigative skills

(2009) Greg Lavine   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Modular Synthesis of Heparan Sulfate Oligosaccharides for Structure−Activity Relationship Studies

(2009) Sailaja Arungundram et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design of biologically active heparan sulfate and heparin using an enzyme-based approach

(2009) Sherket Peterson et al.   NATURAL PRODUCT REPORTS

Lessons learned from the contamination of heparin

(2009) Haiying Liu et al.   NATURAL PRODUCT REPORTS

Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research

(2009) Thomas J. Boltje et al.   Nature Chemistry

The Structure of Glycosaminoglycans and their Interactions with Proteins

(2008) Neha S. Gandhi et al.   Chemical Biology & Drug Design

Solution Structures of Chemoenzymatically Synthesized Heparin and Its Precursors

(2008) Zhenqing Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The FDA and safety—beyond the heparin crisis

(2008) Cato T Laurencin et al.   NATURE BIOTECHNOLOGY

Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events

(2008) Marco Guerrini et al.   NATURE BIOTECHNOLOGY

Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System

(2008) Takashi Kei Kishimoto et al.   NEW ENGLAND JOURNAL OF MEDICINE