Mucosal immunology of HIV infection

Plasticity in programming of effector and memory CD8+T-cell formation

(2015) Ramon Arens et al.   IMMUNOLOGICAL REVIEWS

Endogenous Damage-Associated Molecular Pattern Molecules at the Crossroads of Inflammation and Cancer

(2015) Geetha Srikrishna et al.   NEOPLASIA

The Surprising Discovery That TGF  Specifically Induces the IgA Class Switch

(2014) J. Stavnezer et al.   JOURNAL OF IMMUNOLOGY

The Antibody Response against HIV-1

(2013) J. Overbaugh et al.   Cold Spring Harbor Perspectives in Medicine

Innate Immune Control of HIV

(2013) M. Carrington et al.   Cold Spring Harbor Perspectives in Medicine

Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome

(2012) Scott A. Handley et al.   CELL

Replicating Adenovirus-Simian Immunodeficiency Virus (SIV) Vectors Efficiently Prime SIV-Specific Systemic and Mucosal Immune Responses by Targeting Myeloid Dendritic Cells and Persisting in Rectal Macrophages, Regardless of Immunization Route

(2012) L. Jean Patterson et al.   Clinical and Vaccine Immunology

Editorial (Mucosal Co-Infections and HIV-1 Transmission and Pathogenesis)

(2012) Danny J. Schust et al.   CURRENT HIV RESEARCH

Potential Mechanisms for Increased HIV-1 Transmission Across the Endocervical Epithelium During C. trachomatis Infection

(2012) Danny J. Schust et al.   CURRENT HIV RESEARCH

Animal Models for Microbicide Studies

(2012) Ronald S. Veazey et al.   CURRENT HIV RESEARCH

Innate immunity in the small intestine

(2012) Rebeca Santaolalla et al.   CURRENT OPINION IN GASTROENTEROLOGY

Chemokines at mucosal barriers and their impact on HIV infection

(2012) Magali Rancez et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Soluble mediators of inflammation in HIV and their implications for therapeutics and vaccine development

(2012) Sheila M. Keating et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Expansion of HIV-specific T follicular helper cells in chronic HIV infection

(2012) Madelene Lindqvist et al.   JOURNAL OF CLINICAL INVESTIGATION

CD4 T follicular helper cell dynamics during SIV infection

(2012) Constantinos Petrovas et al.   JOURNAL OF CLINICAL INVESTIGATION

Revealing the role of CD4+T cells in viral immunity: Figure 1.

(2012) Andrea J. Sant et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dominance of the CD4+T helper cell response during acute resolving hepatitis A virus infection

(2012) Yan Zhou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production

(2012) Matthieu Perreau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spatial Alterations between CD4+ T Follicular Helper, B, and CD8+ T Cells during Simian Immunodeficiency Virus Infection: T/B Cell Homeostasis, Activation, and Potential Mechanism for Viral Escape

(2012) J. J. Hong et al.   JOURNAL OF IMMUNOLOGY

NK and CD4+ T Cell Cooperative Immune Responses Correlate with Control of Disease in a Macaque Simian Immunodeficiency Virus Infection Model

(2012) D. A. Vargas-Inchaustegui et al.   JOURNAL OF IMMUNOLOGY

Determinants of Per-Coital-Act HIV-1 Infectivity Among African HIV-1–Serodiscordant Couples

(2012) James P. Hughes et al.   JOURNAL OF INFECTIOUS DISEASES

Gene-Based Vaccination with a Mismatched Envelope Protects against Simian Immunodeficiency Virus Infection in Nonhuman Primates

(2012) L. Flatz et al.   JOURNAL OF VIROLOGY

Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies from an HIV-1 Vaccine Efficacy Trial Target Multiple Epitopes and Preferentially Use the VH1 Gene Family

(2012) M. Bonsignori et al.   JOURNAL OF VIROLOGY

Mucosal Simian Immunodeficiency Virus Transmission in African Green Monkeys: Susceptibility to Infection Is Proportional to Target Cell Availability at Mucosal Sites

(2012) Ivona Pandrea et al.   JOURNAL OF VIROLOGY

Replicating Adenovirus-Simian Immunodeficiency Virus (SIV) Recombinant Priming and Envelope Protein Boosting Elicits Localized, Mucosal IgA Immunity in Rhesus Macaques Correlated with Delayed Acquisition following a Repeated Low-Dose Rectal SIVmac251Challenge

(2012) Peng Xiao et al.   JOURNAL OF VIROLOGY

The activation and dynamics of cytokine expression by CD4+ T cells and AIDS progression in HIV-1-infected Chinese individuals

(2012) Yan Li et al.   MICROBIAL PATHOGENESIS

Human cervicovaginal mucus contains an activity that hinders HIV-1 movement

(2012) S A Shukair et al.   Mucosal Immunology

IL-17-producing innate lymphoid cells are restricted to mucosal tissues and are depleted in SIV-infected macaques

(2012) H Xu et al.   Mucosal Immunology

Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

(2012) Yoshinori Fukazawa et al.   NATURE MEDICINE

Microbial translocation in HIV infection: causes, consequences and treatment opportunities

(2012) Netanya G. Sandler et al.   NATURE REVIEWS MICROBIOLOGY

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD4+ T Cells and HIV: A Paradoxical Pas de Deux

(2012) N. R. Klatt et al.   Science Translational Medicine

HIV-Specific Cytolytic CD4 T Cell Responses During Acute HIV Infection Predict Disease Outcome

(2012) D. Z. Soghoian et al.   Science Translational Medicine

Lymphoid tissue structure and HIV-1 infection: life or death for T cells

(2012) Ming Zeng et al.   TRENDS IN IMMUNOLOGY

Fifteen million people on antiretroviral treatment by 2015

(2012) Reuben Granich et al.   Current Opinion in HIV and AIDS

ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against SIVmac251 Challenge

(2012) Michael D. Alpert et al.   PLoS Pathogens

SIVmac251 Is Inefficiently Transmitted to Rhesus Macaques by Penile Inoculation with a Single SIVenv Variant Found in Ramp-up Phase Plasma

(2011) Zhong-Min Ma et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Innate Immunity in the Human Female Reproductive Tract: Endocrine Regulation of Endogenous Antimicrobial Protection Against HIV and Other Sexually Transmitted Infections

(2011) Charles R. Wira et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Interactions of HIV, Other Sexually Transmitted Diseases, and Genital Tract Inflammation Facilitating Local Pathogen Transmission and Acquisition

(2011) Kenneth H. Mayer et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

New Paradigms for HIV/AIDS Vaccine Development

(2011) Louis J. Picker et al.   Annual Review of Medicine

Structure and Function of Intercellular Junctions in Human Cervical and Vaginal Mucosal Epithelia1

(2011) Caitlin D. Blaskewicz et al.   BIOLOGY OF REPRODUCTION

Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection

(2011) R. K. Reeves et al.   BLOOD

Lymphoid tissue inducer cells

(2011) David R. Withers   CURRENT BIOLOGY

Low Level of Regulatory T Cells and Maintenance of Balance Between Regulatory T Cells and TH17 Cells in HIV-1–Infected Elite Controllers

(2011) Lea Brandt et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

High Susceptibility to Repeated, Low-Dose, Vaginal SHIV Exposure Late in the Luteal Phase of the Menstrual Cycle of Pigtail Macaques

(2011) Sundaram A Vishwanathan et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

(2011) Ming Zeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Depletion of CD4+ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques

(2011) Alexandra M. Ortiz et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate Immune Activation in Intestinal Homeostasis

(2011) Oliver J. Harrison et al.   Journal of Innate Immunity

HIV-Specific CD4 T Cell Responses to Different Viral Proteins Have Discordant Associations with Viral Load and Clinical Outcome

(2011) S. Ranasinghe et al.   JOURNAL OF VIROLOGY

CD4+ T Cells, Including Th17 and Cycling Subsets, Are Intact in the Gut Mucosa of HIV-1-Infected Long-Term Nonprogressors

(2011) E. J. Ciccone et al.   JOURNAL OF VIROLOGY

Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study

(2011) Renee Heffron et al.   LANCET INFECTIOUS DISEASES

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota

(2011) Shinichiro Sawa et al.   NATURE IMMUNOLOGY

Early Divergent Host Responses in SHIVsf162P3 and SIVmac251 Infected Macaques Correlate with Control of Viremia

(2011) Huanbin Xu et al.   PLoS One

Turning the Tide Against HIV

(2011) R. J. Shattock et al.   SCIENCE

Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys

(2011) N. L. Letvin et al.   Science Translational Medicine

Emerging cellular networks for regulation of T follicular helper cells

(2011) Cecile King et al.   TRENDS IN IMMUNOLOGY

Th17 cells and regulatory T cells in elite control over HIV and SIV

(2011) Dennis J Hartigan-OʼConnor et al.   Current Opinion in HIV and AIDS

Dynamics of innate immunity are key to chronic immune activation in AIDS

(2011) Arndt Benecke et al.   Current Opinion in HIV and AIDS

Role of PD-1 in HIV Pathogenesis and as Target for Therapy

(2011) Filippos Porichis et al.   Current HIV/AIDS Reports

Early Events in Sexual Transmission of HIV and SIV and Opportunities for Interventions

(2010) Ashley T. Haase   Annual Review of Medicine

Simian immunodeficiency virus selectively infects proliferating CD4+ T cells in neonatal rhesus macaques

(2010) X. Wang et al.   BLOOD

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Genital secretory immune response to chronic simian immunodeficiency virus (SIV) infection: a comparison between intravenously and genitally inoculated rhesus macaques

(2010) C. J. MILLER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cytolytic CD4+T cells in viral immunity

(2010) Damien Z Soghoian et al.   Expert Review of Vaccines

Induction of Immunity to Human Immunodeficiency Virus Type-1 by Vaccination

(2010) M. Juliana McElrath et al.   IMMUNITY

Interleukin-17A is required to suppress invasion of Salmonella enterica serovar Typhimurium to enteric mucosa

(2010) Hirokazu Mayuzumi et al.   IMMUNOLOGY

Th17 Cytokines and the Gut Mucosal Barrier

(2010) Christoph Blaschitz et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Human NKp44+IL-22+cells and LTi-like cells constitute a stable RORC+lineage distinct from conventional natural killer cells

(2010) Natasha K. Crellin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-7 and IL-15 independently program the differentiation of intestinal CD3−NKp46+cell subsets from Id2-dependent precursors

(2010) Naoko Satoh-Takayama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Large Intestine as a Major Reservoir for Simian Immunodeficiency Virus in Macaques with Long‐Term, Nonprogressing Infection

(2010) Binhua Ling et al.   JOURNAL OF INFECTIOUS DISEASES

Protection of Rhesus Macaques from Vaginal Infection by Vaginally Delivered Maraviroc, an Inhibitor of HIV‐1 Entry via the CCR5 Co‐Receptor

(2010) Ronald S. Veazey et al.   JOURNAL OF INFECTIOUS DISEASES

Antibody-mediated protection and the mucosal immune system of the genital tract: relevance to vaccine design

(2010) Jiri Mestecky et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Comprehensive Analysis of Frequency and Phenotype of T Regulatory Cells in HIV Infection: CD39 Expression of FoxP3+ T Regulatory Cells Correlates with Progressive Disease

(2010) J. Schulze zur Wiesch et al.   JOURNAL OF VIROLOGY

The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling

(2010) Hergen Spits et al.   NATURE IMMUNOLOGY

Innate immune recognition and activation during HIV infection

(2010) Trine H Mogensen et al.   Retrovirology

Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

(2010) S. Hapfelmeier et al.   SCIENCE

The elusive identity of T follicular helper cells

(2010) Di Yu et al.   TRENDS IN IMMUNOLOGY

Polyfunctional analysis of Gag and Nef specific CD8+ T-cell responses in HIV-1 infected Indian individuals

(2010) Sanjay Mendiratta et al.   VACCINE

Th17 cells in pathogenic simian immunodeficiency virus infection of macaques

(2010) Valentina Cecchinato et al.   Current Opinion in HIV and AIDS

Th17 cell dynamics in HIV infection

(2010) Nichole R Klatt et al.   Current Opinion in HIV and AIDS

Damaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections

(2010) Jacob D. Estes et al.   PLoS Pathogens

Exposure to HIV-1 Directly Impairs Mucosal Epithelial Barrier Integrity Allowing Microbial Translocation

(2010) Aisha Nazli et al.   PLoS Pathogens

CD8+ Lymphocytes Control Viral Replication in SIVmac239-Infected Rhesus Macaques without Decreasing the Lifespan of Productively Infected Cells

(2010) Nichole R. Klatt et al.   PLoS Pathogens

The Microbiota Mediates Pathogen Clearance from the Gut Lumen after Non-Typhoidal Salmonella Diarrhea

(2010) Kathrin Endt et al.   PLoS Pathogens

HIV Infection and Gut Mucosal Immune Function: Updates on Pathogenesis with Implications for Management and Intervention

(2010) Barbara L. Shacklett et al.   Current Infectious Disease Reports

Immune activation and AIDS pathogenesis

(2009) Donald L Sodora et al.   AIDS

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Modulation of human β-defensin-2 expression by 17β-estradiol and progesterone in vaginal epithelial cells

(2009) June Hyun Han et al.   CYTOKINE

A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection

(2009) Haina Shin et al.   IMMUNITY

T helper cytokine patterns: defined subsets, random expression, and external modulation

(2009) Tim R. Mosmann et al.   IMMUNOLOGIC RESEARCH

The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

(2009) Nilu Goonetilleke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection

(2009) Jesus F. Salazar-Gonzalez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Kinetics of Expansion of Epitope-Specific T Cell Responses during Primary HIV-1 Infection

(2009) E. L. Turnbull et al.   JOURNAL OF IMMUNOLOGY

Contribution of Nonneutralizing Vaccine-Elicited Antibody Activities to Improved Protective Efficacy in Rhesus Macaques Immunized with Tat/Env Compared with Multigenic Vaccines

(2009) R. H. Florese et al.   JOURNAL OF IMMUNOLOGY

Topically Applied Recombinant Chemokine Analogues Fully Protect Macaques from Vaginal Simian‐Human Immunodeficiency Virus Challenge

(2009) Ronald S. Veazey et al.   JOURNAL OF INFECTIOUS DISEASES

Strong Ability of Nef-Specific CD4+ Cytotoxic T Cells To Suppress Human Immunodeficiency Virus Type 1 (HIV-1) Replication in HIV-1-Infected CD4+ T Cells and Macrophages

(2009) N. Zheng et al.   JOURNAL OF VIROLOGY

Tissue-Specific Differences in PD-1 and PD-L1 Expression during Chronic Viral Infection: Implications for CD8 T-Cell Exhaustion

(2009) S. D. Blackburn et al.   JOURNAL OF VIROLOGY

Analysis of Human Immunodeficiency Virus Type 1 Viremia and Provirus in Resting CD4+ T Cells Reveals a Novel Source of Residual Viremia in Patients on Antiretroviral Therapy

(2009) T. P. Brennan et al.   JOURNAL OF VIROLOGY

Glycerol monolaurate prevents mucosal SIV transmission

(2009) Qingsheng Li et al.   NATURE

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preferential Generation of Follicular B Helper T Cells from Foxp3+ T Cells in Gut Peyer's Patches

(2009) M. Tsuji et al.   SCIENCE

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders

(2009) Masayuki Fukata et al.   SEMINARS IN IMMUNOLOGY

Opening the crypt: current facts and hypotheses on the function of cryptopatches

(2009) Gérard Eberl et al.   TRENDS IN IMMUNOLOGY

Genetic and antigenic features of the transmitted virus

(2009) Brandon F Keele et al.   Current Opinion in HIV and AIDS

Polyclonal B Cell Differentiation and Loss of Gastrointestinal Tract Germinal Centers in the Earliest Stages of HIV-1 Infection

(2009) Marc C. Levesque et al.   PLOS MEDICINE

Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection

(2009) David Favre et al.   PLoS Pathogens

ORIGINAL ARTICLE: Quantification and Comparison of Toll-Like Receptor Expression and Responsiveness in Primary and Immortalized Human Female Lower Genital Tract Epithelia

(2008) Melissa M. Herbst-Kralovetz et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections

(2008) J. M. Brenchley et al.   BLOOD

Toll-Like Receptor Signaling in Small Intestinal Epithelium Promotes B-Cell Recruitment and IgA Production in Lamina Propria

(2008) Limin Shang et al.   GASTROENTEROLOGY

Requirement for Lymphoid Tissue-Inducer Cells in Isolated Follicle Formation and T Cell-Independent Immunoglobulin A Generation in the Gut

(2008) Masayuki Tsuji et al.   IMMUNITY

TNF-α and TLR agonists increase susceptibility to HIV-1 transmission by human Langerhans cells ex vivo

(2008) Marein A.W.P. de Jong et al.   JOURNAL OF CLINICAL INVESTIGATION

Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine

(2008) Colby Zaph et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macaques vaccinated with live-attenuated SIV control replication of heterologous virus

(2008) Matthew R. Reynolds et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Collagen Deposition Limits Immune Reconstitution in the Gut

(2008) Jacob Estes et al.   JOURNAL OF INFECTIOUS DISEASES

Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques

(2008) V Cecchinato et al.   Mucosal Immunology

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

Tropism-independent protection of macaques against vaginal transmission of three SHIVs by the HIV-1 fusion inhibitor T-1249

(2008) R. S. Veazey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection

(2008) B. F. Keele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral tolerance: intestinal homeostasis and antigen-specific regulatory T cells

(2008) Noriko M. Tsuji et al.   TRENDS IN IMMUNOLOGY

AIDSVAX immunization induces HIV-specific CD8+ T-cell responses in high-risk, HIV-negative volunteers who subsequently acquire HIV infection

(2008) Norman G. Jones et al.   VACCINE

Generation of functionally active HIV-1 specific CD8+ CTL in intestinal mucosa following mucosal, systemic or mixed prime-boost immunization

(2008) Igor M. Belyakov et al.   VIROLOGY