期刊
IMMUNOLOGIC RESEARCH
卷 58, 期 2-3, 页码 358-368出版社
HUMANA PRESS INC
DOI: 10.1007/s12026-014-8512-5
关键词
Regulatory T cells; Type 1 regulatory T cells; FOXP3; Allergy; Immune dysregulation
类别
资金
- NIAID NIH HHS [U01 AI147462] Funding Source: Medline
- NIEHS NIH HHS [R21 ES022153] Funding Source: Medline
The main function of the immune system is to fight off potential infections, but also to maintain its activity below a level that would trigger self-reactivity. Regulatory T cells (Tregs) such as forkhead box P3(+) (FOXP3) Tregs and type 1 regulatory T cells (Tr1) play an essential role in this active process, using several distinct suppressive mechanisms. A wide range of pathologies have been associated with altered Treg cell function. This is best exemplified by the impact of mutations of genes essential for Treg function and the associated autoimmune syndromes. This review summarizes the main features of different subtypes of Tregs and focuses on the clinical implications of their altered function in human studies. More specifically, we discuss abnormalities affecting FOXP3(+) Tregs and Tr1 cells that will lead to autoimmune manifestations and/or allergic reactions, and the potential therapeutic use of Tregs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据