Unconventional screening approaches for antibiotic discovery

Insect-Derived Cecropins Display Activity against Acinetobacter baumannii in a Whole-Animal High-Throughput Caenorhabditis elegans Model

(2015) Elamparithi Jayamani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Small Molecule Inhibitors of Clostridium difficile Toxin B-Induced Cellular Damage

(2015) John Tam et al.   CHEMISTRY & BIOLOGY

Discovery of Novel Cell Wall-Active Compounds Using PywaC, a Sensitive Reporter of Cell Wall Stress, in the Model Gram-Positive Bacterium Bacillus subtilis

(2014) T. L. Czarny et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Novel High-Throughput Cell-Based Assay Aimed at Identifying Inhibitors of DNA Metabolism in Bacteria

(2014) Jun Fan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Targeting Bacterial Central Metabolism for Drug Development

(2014) Paul Murima et al.   CHEMISTRY & BIOLOGY

Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model

(2014) V. Torraca et al.   Disease Models & Mechanisms

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

(2014) Andrew M. King et al.   NATURE

Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane

(2014) Hiroshi Hamamoto et al.   Nature Chemical Biology

Requirements for Pseudomonas aeruginosa Acute Burn and Chronic Surgical Wound Infection

(2014) Keith H. Turner et al.   PLoS Genetics

Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth

(2014) Sarah A. Stanley et al.   PLoS Pathogens

Discovery of a small molecule that inhibits bacterial ribosome biogenesis

(2014) Jonathan M Stokes et al.   eLife

Identification of Novel Host-Targeted Compounds That Protect from Anthrax Lethal Toxin-Induced Cell Death

(2013) Louise H. Slater et al.   ACS Chemical Biology

Identification of Novel Inhibitors of Nonreplicating Mycobacterium tuberculosis Using a Carbon Starvation Model

(2013) Sarah Schmidt Grant et al.   ACS Chemical Biology

Image-Based 384-Well High-Throughput Screening Method for the Discovery of Skyllamycins A to C as Biofilm Inhibitors and Inducers of Biofilm Detachment in Pseudomonas aeruginosa

(2013) Gabriel Navarro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing

(2013) Yanjia J. Zhang et al.   CELL

Collapsing the Proton Motive Force to Identify Synergistic Combinations against Staphylococcus aureus

(2013) Maya A. Farha et al.   CHEMISTRY & BIOLOGY

Discovery of Wall Teichoic Acid Inhibitors as Potential Anti-MRSA β-Lactam Combination Agents

(2013) Hao Wang et al.   CHEMISTRY & BIOLOGY

Metal-Induced Isomerization Yields an Intracellular Chelator that Disrupts Bacterial Iron Homeostasis

(2013) Shannon B. Falconer et al.   CHEMISTRY & BIOLOGY

Antibiotic resistance—the need for global solutions

(2013) Ramanan Laxminarayan et al.   LANCET INFECTIOUS DISEASES

Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation

(2013) Soumaya Zlitni et al.   Nature Chemical Biology

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

(2013) Kevin Pethe et al.   NATURE MEDICINE

Advances in the development of new tuberculosis drugs and treatment regimens

(2013) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

DEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elements: Table 1.

(2013) Hao Luo et al.   NUCLEIC ACIDS RESEARCH

A Network Inference Method for Large-Scale Unsupervised Identification of Novel Drug-Drug Interactions

(2013) Roger Guimerà et al.   PLoS Computational Biology

Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening

(2012) Sarah A. Stanley et al.   ACS Chemical Biology

A Forward Chemical Screen Identifies Antibiotic Adjuvants in Escherichia coli

(2012) Patricia L. Taylor et al.   ACS Chemical Biology

A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis

(2012) Puiying A. Mak et al.   ACS Chemical Biology

Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams

(2012) Maya A. Farha et al.   ACS Chemical Biology

Screen for Agents That Induce Autolysis in Bacillus subtilis

(2012) Christopher J. Lacriola et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Whole-Cell Phenotypic Screening Platform for Identifying Methylerythritol Phosphate Pathway-Selective Inhibitors as Novel Antibacterial Agents

(2012) Charles A. Testa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Targeting Persisters for Tuberculosis Control

(2012) Ying Zhang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A fine scale phenotype-genotype virulence map of a bacterial pathogen

(2012) T. van Opijnen et al.   GENOME RESEARCH

Non-Traditional Antibacterial Screening Approaches for the Identification of Novel Inhibitors of the Glyoxylate Shunt in Gram-Negative Pathogens

(2012) Kelly C. Fahnoe et al.   PLoS One

Mechanism-independent method for predicting response to multidrug combinations in bacteria

(2012) Kevin Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals

(2012) Sarah Schmidt Grant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo-Validated Essential Genes Identified in Acinetobacter baumannii by Using Human Ascites Overlap Poorly with Essential Genes Detected on Laboratory Media

(2012) T. C. Umland et al.   mBio

An In Vivo Platform for Rapid High-Throughput Antitubercular Drug Discovery

(2012) Kevin Takaki et al.   Cell Reports

Selective Killing of Bacterial Persisters by a Single Chemical Compound without Affecting Normal Antibiotic-Sensitive Cells

(2011) Jun-Seob Kim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synergistic Drug Combinations for Tuberculosis Therapy Identified by a Novel High-Throughput Screen

(2011) Santiago Ramón-García et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antagonism of Chemical Genetic Interaction Networks Resensitize MRSA to β-Lactam Antibiotics

(2011) Sang Ho Lee et al.   CHEMISTRY & BIOLOGY

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

Host-Pathogen Interactions Made Transparent with the Zebrafish Model

(2011) Annemarie H. Meijer et al.   CURRENT DRUG TARGETS

Discovery research: the scientific challenge of finding new antibiotics

(2011) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

An image-based 384-well high-throughput screening method for the discovery of biofilm inhibitors in Vibrio cholerae

(2011) Kelly C. Peach et al.   Molecular BioSystems

Predicting selective drug targets in cancer through metabolic networks

(2011) O. Folger et al.   Molecular Systems Biology

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

(2011) Linda Ejim et al.   Nature Chemical Biology

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Pyrazinamide Inhibits Trans-Translation in Mycobacterium tuberculosis

(2011) W. Shi et al.   SCIENCE

Prediction of Drug Combinations by Integrating Molecular and Pharmacological Data

(2011) Xing-Ming Zhao et al.   PLoS Computational Biology

Chemical Genomic Approaches to Study Model Microbes

(2010) Courtney A. Barker et al.   CHEMISTRY & BIOLOGY

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

(2010) Julian G. Hurdle et al.   NATURE REVIEWS MICROBIOLOGY

A New Approach for the Discovery of Antibiotics by Targeting Non-Multiplying Bacteria: A Novel Topical Antibiotic for Staphylococcal Infections

(2010) Yanmin Hu et al.   PLoS One

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

(2010) Kevin Pethe et al.   Nature Communications

High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model

(2009) Terence I. Moy et al.   ACS Chemical Biology

A Staphylococcus aureus Fitness Test Platform for Mechanism-Based Profiling of Antibacterial Compounds

(2009) Robert G.K. Donald et al.   CHEMISTRY & BIOLOGY

Chemical Genetic Identification of Peptidoglycan Inhibitors Potentiating Carbapenem Activity against Methicillin-Resistant Staphylococcus aureus

(2009) Joann Huber et al.   CHEMISTRY & BIOLOGY

Pseudomonas aeruginosa Infection of Zebrafish Involves both Host and Pathogen Determinants

(2009) A. E. Clatworthy et al.   INFECTION AND IMMUNITY

Nitazoxanide Kills Replicating and NonreplicatingMycobacterium tuberculosisand Evades Resistance

(2009) Luiz Pedro S. de Carvalho et al.   JOURNAL OF MEDICINAL CHEMISTRY

Are essential genes really essential?

(2009) Michael A. D’Elia et al.   TRENDS IN MICROBIOLOGY

Recent advances and method development for drug target identification

(2009) Janet N.Y. Chan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors

(2009) Thierry Christophe et al.   PLoS Pathogens

An Inhibitor of Gram-Negative Bacterial Virulence Protein Secretion

(2008) Heather B. Felise et al.   Cell Host & Microbe

Revisiting the host as a growth medium

(2008) Stacie A. Brown et al.   NATURE REVIEWS MICROBIOLOGY