Prediction of Drug Combinations by Integrating Molecular and Pharmacological Data

Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways

(2011) Siyuan Zhang et al.   NATURE MEDICINE

Network Neighbors of Drug Targets Contribute to Drug Side-Effect Similarity

(2011) Lucas Brouwers et al.   PLoS One

Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework

(2010) Y. Yamanishi et al.   BIOINFORMATICS

A systems biology approach to identify effective cocktail drugs

(2010) Zikai Wu et al.   BMC Systems Biology

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma

(2010) Yvonne J. Huang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A side effect resource to capture phenotypic effects of drugs

(2010) Michael Kuhn et al.   Molecular Systems Biology

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

Identifying Unexpected Therapeutic Targets via Chemical-Protein Interactome

(2010) Lun Yang et al.   PLoS One

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination therapy in hypertension: An update

(2010) Sanjay Kalra et al.   Diabetology & Metabolic Syndrome

Drug-Induced Regulation of Target Expression

(2010) Murat Iskar et al.   PLoS Computational Biology

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Synergistic drug combinations tend to improve therapeutically relevant selectivity

(2009) Joseph Lehár et al.   NATURE BIOTECHNOLOGY

Mechanisms of drug combinations: interaction and network perspectives

(2009) Jia Jia et al.   NATURE REVIEWS DRUG DISCOVERY

STITCH 2: an interaction network database for small molecules and proteins

(2009) Michael Kuhn et al.   NUCLEIC ACIDS RESEARCH

KEGG for representation and analysis of molecular networks involving diseases and drugs

(2009) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Large-scale prediction of drug-target relationships

(2008) Michael Kuhn et al.   FEBS LETTERS

12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels

(2008) Amanda R. Hajek et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy of glimepiride/metformin combination versus glibenclamide/metformin in patients with uncontrolled type 2 diabetes mellitus

(2008) Manuel González-Ortiz et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm

(2008) Pak Kin Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE