Discovery research: the scientific challenge of finding new antibiotics

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

8-Azatetracyclines: Synthesis and Evaluation of a Novel Class of Tetracycline Antibacterial Agents

(2011) Roger B. Clark et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activities of NXL104 Combinations with Ceftazidime and Aztreonam against Carbapenemase-ProducingEnterobacteriaceae

(2010) David M. Livermore et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Potentiation of Carbapenems with ME1071, a Novel Metallo- -Lactamase Inhibitor, against Metallo- -Lactamase- Producing Pseudomonas aeruginosa Clinical Isolates

(2010) Y. Ishii et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and Spectrum of the Neoglycoside ACHN-490

(2010) J. B. Aggen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A guide to successful bioprospecting: informed by actinobacterial systematics

(2010) Michael Goodfellow et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosus

(2010) Jörg Barke et al.   BMC BIOLOGY

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Alarming β-lactamase-mediated resistance in multidrug-resistant Enterobacteriaceae

(2010) Karen Bush   CURRENT OPINION IN MICROBIOLOGY

Polymyxins and their novel derivatives

(2010) Martti Vaara   CURRENT OPINION IN MICROBIOLOGY

Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces

(2010) Juan-Francisco Martín et al.   CURRENT OPINION IN MICROBIOLOGY

Distribution of 16S rRNA methylases among different species of Gram-negative bacilli with high-level resistance to aminoglycosides

(2010) Y. Zhou et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Type IIA topoisomerase inhibition by a new class of antibacterial agents

(2010) Benjamin D. Bax et al.   NATURE

A Wellcome experiment in seeding drug discovery

(2010)   NATURE REVIEWS DRUG DISCOVERY

Mechanisms of RND multidrug efflux pumps

(2008) Hiroshi Nikaido et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS