Natural antioxidants for non-alcoholic fatty liver disease: molecular targets and clinical perspectives

Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: A randomized controlled trial

(2015) Shihui Chen et al.   DIGESTIVE AND LIVER DISEASE

Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study

(2015) Raul Zamora-Ros et al.   EUROPEAN JOURNAL OF NUTRITION

Naringenin reduces cholesterol-induced hepatic inflammation in rats by modulating matrix metalloproteinases-2, 9 via inhibition of nuclear factor κB pathway

(2015) Yassine Chtourou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

(2015) Paul Angulo et al.   GASTROENTEROLOGY

Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: Findings and recommendations from an American Association for the Study of Liver Diseases-U.S. Food and Drug Administration Joint Workshop

(2015) Arun J. Sanyal et al.   HEPATOLOGY

Hesperetin derivative-7 inhibits PDGF-BB-induced hepatic stellate cell activation and proliferation by targeting Wnt/β-catenin pathway

(2015) Xiang Lin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A CONSORT-Compliant, Randomized, Double-Blind, Placebo-Controlled Pilot Trial of Purified Anthocyanin in Patients With Nonalcoholic Fatty Liver Disease

(2015) Pei-Wen Zhang et al.   MEDICINE

Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population

(2015) Shira Zelber-Sagi et al.   Translational Research

Efficacy of Lifestyle Changes in Subjects with Non-Alcoholic Liver Steatosis and Metabolic Syndrome May Be Improved with an Antioxidant Nutraceutical: A Controlled Clinical Study

(2015) Gianpaolo Sorrentino et al.   Drugs in research & development

Effects of Mediterranean diet supplemented with silybin–vitamin E–phospholipid complex in overweight patients with non-alcoholic fatty liver disease

(2015) Ludovico Abenavoli et al.   Expert Review of Gastroenterology & Hepatology

Coffee Consumption and Mortality From All Causes, Cardiovascular Disease, and Cancer: A Dose-Response Meta-Analysis

(2014) Alessio Crippa et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Troxerutin improves hepatic lipid homeostasis by restoring NAD+-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice

(2014) Zi-Feng Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Coffee induces autophagy in vivo

(2014) Federico Pietrocola et al.   CELL CYCLE

Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease

(2014) Veronique S. Chachay et al.   Clinical Gastroenterology and Hepatology

State of the art

(2014) Michelle Pearlman et al.   CURRENT OPINION IN GASTROENTEROLOGY

Impact of lifestyle on metabolic syndrome in apparently healthy people

(2014) Silvio Buscemi et al.   Eating and Weight Disorders-Studies on Anorexia Bulimia and Obesity

Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study

(2014) Giuseppe Grosso et al.   EUROPEAN JOURNAL OF NUTRITION

Coffee, alcohol and other beverages in relation to cirrhosis mortality: The Singapore Chinese Health Study

(2014) George Boon-Bee Goh et al.   HEPATOLOGY

Inverse associations of total and decaffeinated coffee with liver enzyme levels in National Health and Nutrition Examination Survey 1999-2010

(2014) Qian Xiao et al.   HEPATOLOGY

Coffee components and cardiovascular risk: beneficial and detrimental effects

(2014) Justyna Godos et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Factors Associated With Metabolic Syndrome in a Mediterranean Population: Role of Caffeinated Beverages

(2014) Giuseppe Grosso et al.   JOURNAL OF EPIDEMIOLOGY

Antifibrotic activity of hesperidin against dimethylnitrosamine-induced liver fibrosis in rats

(2014) Shimaa M. Elshazly et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Estimated dietary intake and major food sources of polyphenols in the Polish arm of the HAPIEE study

(2014) Giuseppe Grosso et al.   NUTRITION

Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease

(2014) Forouzan Faghihzadeh et al.   NUTRITION RESEARCH

Serum Oxidative Stress Markers and Lipidomic Profile to Detect NASH Patients Responsive to an Antioxidant Treatment: A Pilot Study

(2014) Paola Stiuso et al.   Oxidative Medicine and Cellular Longevity

Hesperidin Prevents Liver Fibrosis in Rats by Decreasing the Expression of Nuclear Factor-κB, Transforming Growth Factor-� and Connective Tissue Growth Factor

(2014) J. Eliuth Pérez-Vargas et al.   PHARMACOLOGY

Gelidium elegans, an Edible Red Seaweed, and Hesperidin Inhibit Lipid Accumulation and Production of Reactive Oxygen Species and Reactive Nitrogen Species in 3T3-L1 and RAW264.7 Cells

(2014) Hui-Jeon Jeon et al.   PHYTOTHERAPY RESEARCH

Effects of resveratrol on gut microbiota and fat storage in a mouse model with high-fat-induced obesity

(2014) Yi Qiao et al.   Food & Function

Wild blueberry (Vaccinium angustifolium)-enriched diet improves dyslipidaemia and modulates the expression of genes related to lipid metabolism in obese Zucker rats

(2013) Stefano Vendrame et al.   BRITISH JOURNAL OF NUTRITION

Pathophysiology of NASH: Perspectives for a Targeted Treatment

(2013) Fabio Marra et al.   CURRENT PHARMACEUTICAL DESIGN

Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways

(2013) Jia Xiao et al.   EUROPEAN JOURNAL OF NUTRITION

Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice

(2013) Rohit A. Sinha et al.   HEPATOLOGY

Effect of chlorogenic acid on LPS-induced proinflammatory signaling in hepatic stellate cells

(2013) Haitao Shi et al.   INFLAMMATION RESEARCH

Silibinin ameliorates steatosis and insulin resistance during non-alcoholic fatty liver disease development partly through targeting IRS-1/PI3K/Akt pathway

(2013) Yongxiang Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Consumption of polyphenol-rich juar tea increases endothelium-bound extracellular superoxide dismutase levels in men with metabolic syndrome: link with LDL oxidizability

(2013) Harumi Uto-Kondo et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Caffeine attenuates liver fibrosis via defective adhesion of hepatic stellate cells in cirrhotic model

(2013) Sung Gon Shim et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Unconjugated bilirubin, a potent endogenous antioxidant, is decreased in patients with non-alcoholic steatohepatitis and advanced fibrosis

(2013) Federico Salomone et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Novel insights of dietary polyphenols and obesity

(2013) Shu Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Non-alcoholic fatty liver disease independently predicts prediabetes during a 7-year prospective follow-up

(2013) Shira Zelber-Sagi et al.   LIVER INTERNATIONAL

Coffee consumption in NAFLD patients with lower insulin resistance is associated with lower risk of severe fibrosis

(2013) Kiran Bambha et al.   LIVER INTERNATIONAL

Chemoprevention of nonalcoholic fatty liver disease by dietary natural compounds

(2013) Min-Hsiung Pan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Red Orange: Experimental Models and Epidemiological Evidence of Its Benefits on Human Health

(2013) Giuseppe Grosso et al.   Oxidative Medicine and Cellular Longevity

Dietary Anthocyanins as Nutritional Therapy for Nonalcoholic Fatty Liver Disease

(2013) Luca Valenti et al.   Oxidative Medicine and Cellular Longevity

Rutin Suppresses Palmitic Acids-Triggered Inflammation in Macrophages and Blocks High Fat Diet-Induced Obesity and Fatty Liver in Mice

(2013) Mingming Gao et al.   PHARMACEUTICAL RESEARCH

Quercetin Induces Hepatic Lipid Omega-Oxidation and Lowers Serum Lipid Levels in Mice

(2013) Elise F. Hoek-van den Hil et al.   PLoS One

Coffee enhances the expression of chaperones and antioxidant proteins in rats with nonalcoholic fatty liver disease

(2013) Federico Salomone et al.   Translational Research

PNPLA3 I148M polymorphism and progressive liver disease

(2013) Paola Dongiovanni   WORLD JOURNAL OF GASTROENTEROLOGY

Citrus Flavanones Affect Hepatic Fatty Acid Oxidation in Rats by Acting as Prooxidant Agents

(2013) Rodrigo Polimeni Constantin et al.   Biomed Research International

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

(2012) Daniele Del Rio et al.   ANTIOXIDANTS & REDOX SIGNALING

Curcumin inhibits gene expression of receptor for advanced glycation end-products (RAGE) in hepatic stellate cells in vitro by elevating PPARγ activity and attenuating oxidative stress

(2012) Jianguo Lin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resveratrol Attenuates Obesity-Associated Peripheral and Central Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet

(2012) B. T. Jeon et al.   DIABETES

Cyanidin-3-O-β-glucoside, a typical anthocyanin, exhibits antilipolytic effects in 3T3-L1 adipocytes during hyperglycemia: Involvement of FoxO1-mediated transcription of adipose triglyceride lipase

(2012) Honghui Guo et al.   FOOD AND CHEMICAL TOXICOLOGY

Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial

(2012) Carmela Loguercio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro-fibrogenic/anti-fibrogenic molecules balance

(2012) Luis Daniel Hernández-Ortega et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Quercetin Ameliorates Cardiovascular, Hepatic, and Metabolic Changes in Diet-Induced Metabolic Syndrome in Rats

(2012) Sunil K. Panchal et al.   JOURNAL OF NUTRITION

Quercetin Treatment Ameliorates Inflammation and Fibrosis in Mice with Nonalcoholic Steatohepatitis1–3

(2012) Eder Marcolin et al.   JOURNAL OF NUTRITION

Cyanidin-3-O-β-glucoside regulates fatty acid metabolism via an AMP-activated protein kinase-dependent signaling pathway in human HepG2 cells

(2012) Honghui Guo et al.   Lipids in Health and Disease

Baicalein, a natural product, selectively activating AMPKα2 and ameliorates metabolic disorder in diet-induced mice

(2012) Peng Pu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet

(2012) Goiuri Alberdi et al.   NUTRITION

Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats

(2012) Pankaj K. Bagul et al.   PHARMACOLOGICAL RESEARCH

Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis

(2012) Federico Salamone et al.   Translational Research

Moroorange juice prevents fatty liver in mice

(2012) Federico Salamone   WORLD JOURNAL OF GASTROENTEROLOGY

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Theaflavin attenuates ischemia–reperfusion injury in a mouse fatty liver model

(2011) Xiao-Yu Luo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress

(2011) S. Gómez-Zorita et al.   BRITISH JOURNAL OF NUTRITION

Reduction of body weight, liver steatosis and expression of stearoyl-CoA desaturase 1 by the isoflavone daidzein in diet-induced obesity

(2011) A Crespillo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Coffee consumption and reduced risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study

(2011) Shane Johnson et al.   CANCER CAUSES & CONTROL

Silibinin improves hepatic and myocardial injury in mice with nonalcoholic steatohepatitis

(2011) Federico Salamone et al.   DIGESTIVE AND LIVER DISEASE

The anthocyanin cyanidin-3-O-β-glucoside, a flavonoid, increases hepatic glutathione synthesis and protects hepatocytes against reactive oxygen species during hyperglycemia: Involvement of a cAMP–PKA-dependent signaling pathway

(2011) Wei Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis

(2011) Jeffrey W. Molloy et al.   HEPATOLOGY

Acute effects of epigallocatechin gallate from green tea on oxidation and tissue incorporation of dietary lipids in mice fed a high-fat diet

(2011) M Friedrich et al.   INTERNATIONAL JOURNAL OF OBESITY

Mulberry Water Extracts Possess an Anti-obesity Effect and Ability To Inhibit Hepatic Lipogenesis and Promote Lipolysis

(2011) Chiung-Huei Peng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Suppression of Amphiregulin/Epidermal Growth Factor Receptor Signals Contributes to the Protective Effects of Quercetin in Cirrhotic Rats

(2011) María J. Cuevas et al.   JOURNAL OF NUTRITION

Rutin Attenuates Metabolic Changes, Nonalcoholic Steatohepatitis, and Cardiovascular Remodeling in High-Carbohydrate, High-Fat Diet-Fed Rats

(2011) Sunil K. Panchal et al.   JOURNAL OF NUTRITION

Effects of Hesperidin on the Progression of Hypercholesterolemia and Fatty Liver Induced by High-Cholesterol Diet in Rats

(2011) Xinhui Wang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes

(2011) LaNita A Nichols et al.   Lipids in Health and Disease

Nutrition and physical activity in NAFLD: An overview of the epidemiological evidence

(2011) Shira Zelber-Sagi   WORLD JOURNAL OF GASTROENTEROLOGY

The inhibitory effect of genistein on hepatic steatosis is linked to visceral adipocyte metabolism in mice with diet-induced non-alcoholic fatty liver disease

(2010) Mi-Hyun Kim et al.   BRITISH JOURNAL OF NUTRITION

Coffee reduces liver damage in a rat model of steatohepatitis: The underlying mechanisms and the role of polyphenols and melanoidins

(2010) Paola Vitaglione et al.   HEPATOLOGY

Daidzein supplementation prevents non-alcoholic fatty liver disease through alternation of hepatic gene expression profiles and adipocyte metabolism

(2010) M-H Kim et al.   INTERNATIONAL JOURNAL OF OBESITY

Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice

(2010) Masuko Kobori et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Reduction of lipid accumulation in HepG2 Cells by luteolin is associated with activation of AMPK and Mitigation of oxidative stress

(2010) Jin-Feng Liu et al.   PHYTOTHERAPY RESEARCH

Naringenin Prevents Dyslipidemia, Apolipoprotein B Overproduction, and Hyperinsulinemia in LDL Receptor-Null Mice With Diet-Induced Insulin Resistance

(2009) E. E. Mulvihill et al.   DIABETES

Grapes, Wines, Resveratrol, and Heart Health

(2009) Alberto A A Bertelli et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Curcumin limits the fibrogenic evolution of experimental steatohepatitis

(2009) Francesco Vizzutti et al.   LABORATORY INVESTIGATION

Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase

(2008) Jing SHANG et al.   ACTA PHARMACOLOGICA SINICA

Resveratrol attenuates the expression of HMG-CoA reductase mRNA in hamsters

(2008) Il Jin Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Altered Hyperlipidemia, Hepatic Steatosis, and Hepatic Peroxisome Proliferator-Activated Receptors in Rats with Intake of Tart Cherry

(2008) E. Mitchell Seymour et al.   JOURNAL OF MEDICINAL FOOD

Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cellsin vitroby blocking NF-κB and ERK signalling

(2007) A Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential effects of dietary flavonoids on reactive oxygen and nitrogen species generation and changes in antioxidant enzyme expression induced by proinflammatory cytokines in Chang Liver cells

(2007) Irene Crespo et al.   FOOD AND CHEMICAL TOXICOLOGY

Epigallocatechin gallate attenuates experimental non-alcoholic steatohepatitis induced by high fat diet

(2007) Nalan Kuzu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY